IL44357A - Anthelmintic composition containing 2-benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4h-pyrazino (2,1-a) isoquinoline - Google Patents
Anthelmintic composition containing 2-benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4h-pyrazino (2,1-a) isoquinolineInfo
- Publication number
- IL44357A IL44357A IL44357A IL4435774A IL44357A IL 44357 A IL44357 A IL 44357A IL 44357 A IL44357 A IL 44357A IL 4435774 A IL4435774 A IL 4435774A IL 44357 A IL44357 A IL 44357A
- Authority
- IL
- Israel
- Prior art keywords
- anthelmintic
- compound
- liquid
- oxo
- isoquinoline
- Prior art date
Links
- 230000000507 anthelmentic effect Effects 0.000 title claims abstract description 23
- XEYCCEDRIDKXEV-UHFFFAOYSA-N 2-benzoyl-3,6,7,11b-tetrahydro-1h-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1=CC=CC=C1 XEYCCEDRIDKXEV-UHFFFAOYSA-N 0.000 title abstract 2
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- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- 235000010296 thiabendazole Nutrition 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- NSBGJRFJIJFMGW-UHFFFAOYSA-N trisodium;stiborate Chemical compound [Na+].[Na+].[Na+].[O-][Sb]([O-])([O-])=O NSBGJRFJIJFMGW-UHFFFAOYSA-N 0.000 description 1
- 208000037972 tropical disease Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2312134A DE2312134C2 (de) | 1973-03-12 | 1973-03-12 | Anthelmintikum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44357A0 IL44357A0 (en) | 1974-06-30 |
| IL44357A true IL44357A (en) | 1977-02-28 |
Family
ID=5874496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44357A IL44357A (en) | 1973-03-12 | 1974-03-05 | Anthelmintic composition containing 2-benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4h-pyrazino (2,1-a) isoquinoline |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3993759A (de) |
| JP (1) | JPS5740810B2 (de) |
| BE (1) | BE812120A (de) |
| CA (1) | CA1030068A (de) |
| DD (1) | DD110431A5 (de) |
| DE (1) | DE2312134C2 (de) |
| EG (1) | EG14407A (de) |
| ES (1) | ES424178A1 (de) |
| FR (1) | FR2221136B1 (de) |
| GB (1) | GB1408542A (de) |
| IE (1) | IE39045B1 (de) |
| IL (1) | IL44357A (de) |
| NL (1) | NL180069C (de) |
| ZA (1) | ZA741086B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303659A (en) * | 1979-08-22 | 1981-12-01 | Pfizer Inc. | Schistosomicidal compositions |
| JPS6113121U (ja) * | 1984-06-28 | 1986-01-25 | シャープ株式会社 | 灯油気化バ−ナ− |
| US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470062A1 (de) * | 1964-02-06 | 1969-05-08 | E Merck Ag Fa | Verfahren zur Herstellung von 1,2,3,6,7,11 b-Hexahydro-4 H-pyrazino-[2,1-a]-isochinolinen |
| US3682926A (en) * | 1971-04-19 | 1972-08-08 | Archer Sydney | Tetrahydroiso quinolinecarboxamides |
-
1973
- 1973-03-12 DE DE2312134A patent/DE2312134C2/de not_active Expired
-
1974
- 1974-02-19 ZA ZA00741086A patent/ZA741086B/xx unknown
- 1974-02-19 IE IE00323/74A patent/IE39045B1/xx unknown
- 1974-02-26 GB GB862674A patent/GB1408542A/en not_active Expired
- 1974-03-05 IL IL44357A patent/IL44357A/en unknown
- 1974-03-08 DD DD177072A patent/DD110431A5/xx unknown
- 1974-03-11 FR FR7408187A patent/FR2221136B1/fr not_active Expired
- 1974-03-11 JP JP49028446A patent/JPS5740810B2/ja not_active Expired
- 1974-03-11 CA CA194,544A patent/CA1030068A/en not_active Expired
- 1974-03-11 EG EG172/74A patent/EG14407A/xx active
- 1974-03-11 NL NLAANVRAGE7403228,A patent/NL180069C/xx not_active IP Right Cessation
- 1974-03-11 US US05/449,690 patent/US3993759A/en not_active Expired - Lifetime
- 1974-03-11 BE BE141857A patent/BE812120A/xx not_active IP Right Cessation
- 1974-03-12 ES ES424178A patent/ES424178A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE812120A (fr) | 1974-09-11 |
| NL180069C (nl) | 1987-01-02 |
| DD110431A5 (de) | 1974-12-20 |
| ZA741086B (en) | 1975-01-29 |
| FR2221136B1 (de) | 1976-09-03 |
| US3993759A (en) | 1976-11-23 |
| ES424178A1 (es) | 1976-09-01 |
| FR2221136A1 (de) | 1974-10-11 |
| EG14407A (en) | 1984-03-31 |
| DE2312134C2 (de) | 1983-05-05 |
| JPS5740810B2 (de) | 1982-08-30 |
| NL7403228A (de) | 1974-09-16 |
| JPS49118823A (de) | 1974-11-13 |
| GB1408542A (en) | 1975-10-01 |
| DE2312134A1 (de) | 1974-09-19 |
| IE39045B1 (en) | 1978-07-19 |
| AU6654674A (en) | 1975-09-18 |
| IL44357A0 (en) | 1974-06-30 |
| CA1030068A (en) | 1978-04-25 |
| NL180069B (nl) | 1986-08-01 |
| IE39045L (en) | 1974-09-12 |
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