IL44056A - Theophylline-acetate salts of isoquinoline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Theophylline-acetate salts of isoquinoline derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL44056A IL44056A IL44056A IL4405674A IL44056A IL 44056 A IL44056 A IL 44056A IL 44056 A IL44056 A IL 44056A IL 4405674 A IL4405674 A IL 4405674A IL 44056 A IL44056 A IL 44056A
- Authority
- IL
- Israel
- Prior art keywords
- general formula
- compounds
- theophylline
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 4
- VYEYJCBEXFTGBN-UHFFFAOYSA-N acetic acid;1,3-dimethyl-7h-purine-2,6-dione Chemical class CC(O)=O.O=C1N(C)C(=O)N(C)C2=C1NC=N2 VYEYJCBEXFTGBN-UHFFFAOYSA-N 0.000 title 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 7
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 10
- HCYFGRCYSCXKNQ-UHFFFAOYSA-N 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetic acid Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)=O)C=N2 HCYFGRCYSCXKNQ-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 231100000636 lethal dose Toxicity 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960001789 papaverine Drugs 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229960000278 theophylline Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 101800004637 Communis Proteins 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 241001077660 Molo Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000002082 anti-convulsion Effects 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000002371 cardiac agent Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- OJYGBLRPYBAHRT-IPQSZEQASA-N chloralose Chemical compound O1[C@H](C(Cl)(Cl)Cl)O[C@@H]2[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]21 OJYGBLRPYBAHRT-IPQSZEQASA-N 0.000 description 1
- 229950009941 chloralose Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002537 isoquinolines Chemical class 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
- 229940012189 methyl orange Drugs 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI1333A HU167246B (en, 2012) | 1973-01-25 | 1973-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL44056A true IL44056A (en) | 1977-01-31 |
Family
ID=10994468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44056A IL44056A (en) | 1973-01-25 | 1974-01-22 | Theophylline-acetate salts of isoquinoline derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4035366A (en, 2012) |
| JP (1) | JPS6043351B2 (en, 2012) |
| BE (1) | BE810145A (en, 2012) |
| CA (1) | CA1018160A (en, 2012) |
| DE (1) | DE2403122A1 (en, 2012) |
| ES (1) | ES422694A1 (en, 2012) |
| FR (1) | FR2221134B1 (en, 2012) |
| GB (1) | GB1417542A (en, 2012) |
| HU (1) | HU167246B (en, 2012) |
| IL (1) | IL44056A (en, 2012) |
| SU (1) | SU506298A3 (en, 2012) |
| YU (1) | YU19274A (en, 2012) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2368277A1 (fr) * | 1976-10-21 | 1978-05-19 | Sobio Lab | Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique |
| FR2377385A2 (fr) * | 1977-01-12 | 1978-08-11 | Sobio Lab | Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique |
| JPS614663U (ja) * | 1984-06-13 | 1986-01-11 | 日輪ゴム工業株式会社 | ゲ−ム用ボ−ル |
| HU194179B (en) * | 1985-10-03 | 1988-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for production of 1-/3',4'-dietoxi-benzil/-1,6,7-dietoxi-3,4-dihydro-izoquinolinine-teophilin-7-acetate and their new cristallic monohydrate |
| HU197207B (en) * | 1985-12-04 | 1989-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical comprising 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium-theophylline-7-acetate or its monohydrate as active ingredient |
| JPS6384261U (en, 2012) * | 1986-11-19 | 1988-06-02 | ||
| JPS63154049U (en, 2012) * | 1987-03-28 | 1988-10-11 | ||
| JPS63160864U (en, 2012) * | 1987-04-08 | 1988-10-20 | ||
| HUT60926A (en) | 1991-04-12 | 1992-11-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical composition suitable for reducing or preventing increased thrombocyte-aggregation capability |
| JP3276762B2 (ja) * | 1993-12-28 | 2002-04-22 | 日本臓器製薬株式会社 | イソキノリン誘導体を含有する医薬組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2975M (fr) * | 1963-09-02 | 1964-11-30 | Agrologique Francaise Soc | Nouveaux médicaments a base de dérivés alcaloides de l'acide théophylline-acétique. |
| FR1369374A (fr) * | 1963-04-26 | 1964-08-14 | Agrologique Francaise Soc | Dérivés alcaloïdes de l'acide théophylline-acétique et leur procédé de fabrication |
| FR3625M (fr) * | 1964-05-14 | 1965-10-18 | Gerda Lab | Médicament constitué par des dérivés de l'acide théophylline-acétique. |
-
1973
- 1973-01-25 HU HUCI1333A patent/HU167246B/hu unknown
-
1974
- 1974-01-22 US US05/435,591 patent/US4035366A/en not_active Expired - Lifetime
- 1974-01-22 IL IL44056A patent/IL44056A/en unknown
- 1974-01-23 DE DE2403122A patent/DE2403122A1/de active Granted
- 1974-01-23 FR FR7402194A patent/FR2221134B1/fr not_active Expired
- 1974-01-23 ES ES422694A patent/ES422694A1/es not_active Expired
- 1974-01-24 JP JP49009826A patent/JPS6043351B2/ja not_active Expired
- 1974-01-24 SU SU1999306A patent/SU506298A3/ru active
- 1974-01-24 GB GB329974A patent/GB1417542A/en not_active Expired
- 1974-01-24 CA CA190,817A patent/CA1018160A/en not_active Expired
- 1974-01-25 BE BE140161A patent/BE810145A/xx not_active IP Right Cessation
- 1974-01-25 YU YU00192/74A patent/YU19274A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES422694A1 (es) | 1976-09-01 |
| BE810145A (fr) | 1974-05-16 |
| DE2403122A1 (de) | 1974-08-01 |
| JPS5046818A (en, 2012) | 1975-04-25 |
| FR2221134B1 (en, 2012) | 1976-09-03 |
| HU167246B (en, 2012) | 1975-09-27 |
| SU506298A3 (ru) | 1976-03-05 |
| YU19274A (en) | 1983-01-21 |
| US4035366A (en) | 1977-07-12 |
| GB1417542A (en) | 1975-12-10 |
| AU6477874A (en) | 1975-07-24 |
| JPS6043351B2 (ja) | 1985-09-27 |
| DE2403122C2 (en, 2012) | 1990-03-22 |
| FR2221134A1 (en, 2012) | 1974-10-11 |
| CA1018160A (en) | 1977-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3341594A (en) | 1-(3, 5-dihydroxy-phenyl)-1-hydroxy-2-isopropylamino-ethane and salts thereof | |
| IE832186L (en) | 3,7-diazabicyclo (3,3,1) nonanes | |
| EP0204269B1 (de) | Pyridin-Derivate, ihre Herstellung und Verwendung | |
| EP0198456B1 (en) | 1,7-naphthyridine derivatives and medicinal preparations containing same | |
| IE47884B1 (en) | Xanthine derivatives having antiallergic activity and pharmacological preparations containing them | |
| IL44056A (en) | Theophylline-acetate salts of isoquinoline derivatives,their preparation and pharmaceutical compositions containing them | |
| AT395009B (de) | Verfahren zur herstellung neuer 1-(hydroxystyryl)-5h-2,3-benzodiazepin-derivate | |
| DE68925270T2 (de) | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidinderivate und diese enthaltende Arzneimittel | |
| HK125096A (en) | Expectorant comprising hydroxy-alkylcysteine derivative | |
| GB1569251A (en) | Pyridobenzodiazepines | |
| DE2040510C3 (de) | Oxazole- und Thiazole eckige Klammer auf 5,4-d] azepin- Derivate | |
| US3975524A (en) | 3-Piperazino-isoquinolines and salts thereof | |
| DE2117657B2 (de) | Pyrido eckige klammer auf 3,2- d eckige klammer zu pyrimidine | |
| US3880862A (en) | 6{62 -Azido-17-cycloalkylmethyl-4,5{60 -epoxymorphinan-3-ols | |
| US3792057A (en) | Substituted indenoimidazoles | |
| DE2724478A1 (de) | Neue, in 11-stellung substituierte 5,11-dihydro-6h-pyrido eckige klammer auf 2,3-b eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
| DD146823A5 (de) | Verfahren zur herstellung von aminopropanolderivaten des 6-hydroxy-2,3,4,5-tetrahydro-1 h-1-benzazepin-2-ons | |
| US4420481A (en) | Use of piperazine compounds as immunopotentiating agents | |
| DD268940A5 (de) | Verfahren zur herstellung von neuen 3-(hydroxymethyl)-isochinolin-derivaten | |
| EP0000693A1 (de) | Aminophenoxymethyl-2-morpholinderivate, ihre Herstellung und sie enthaltende Arzneimittel | |
| US4745118A (en) | Substituted quinazoline-3-oxides providing pharmacological activity | |
| CA1112651A (en) | Salt of 2,8-dicarboxy-4,6-dioxy-10-propyl-4h,6h- benzo(1,2-b:5,4-b')dipyran | |
| US3676439A (en) | 5,6-dihydro-8,8-dimethyl-3-nitro-8h imidazo(2-1-c) (1,4)oxazine | |
| US3882127A (en) | 17-alkenyl-6{62 -azido-4,5{60 -epoxymorphinan-3-ols | |
| US3553267A (en) | 3-dimethylamino-1,2,3,4-tetrahydrofluorene |