IL43544A - 10(3-(4-(2-hydroxyethoxy)-4-alkyl)piperidino)-propyl-2-trifluoromethyl-phenothiazine derivatives,process for preparing them and pharmaceutical compositions containing them - Google Patents
10(3-(4-(2-hydroxyethoxy)-4-alkyl)piperidino)-propyl-2-trifluoromethyl-phenothiazine derivatives,process for preparing them and pharmaceutical compositions containing themInfo
- Publication number
- IL43544A IL43544A IL43544A IL4354473A IL43544A IL 43544 A IL43544 A IL 43544A IL 43544 A IL43544 A IL 43544A IL 4354473 A IL4354473 A IL 4354473A IL 43544 A IL43544 A IL 43544A
- Authority
- IL
- Israel
- Prior art keywords
- trifluoromethyl
- formula
- propyl
- preparing
- piperidino
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 decanoyloxy Chemical group 0.000 claims abstract 6
- 239000002253 acid Substances 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- BZEJZIAESDBOJX-UHFFFAOYSA-N 10-(3-chloropropyl)-2-(trifluoromethyl)phenothiazine Chemical compound C1=CC=C2N(CCCCl)C3=CC(C(F)(F)F)=CC=C3SC2=C1 BZEJZIAESDBOJX-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims abstract 2
- RKGYJVASTMCSHZ-UHFFFAOYSA-N 2-(trifluoromethyl)-10H-phenothiazine Chemical compound C1=CC=C2NC3=CC(C(F)(F)F)=CC=C3SC2=C1 RKGYJVASTMCSHZ-UHFFFAOYSA-N 0.000 claims 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 2
- 239000011976 maleic acid Substances 0.000 abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- IPIVAXLHTVNRBS-UHFFFAOYSA-N decanoyl chloride Chemical compound CCCCCCCCCC(Cl)=O IPIVAXLHTVNRBS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- ARBOVOVUTSQWSS-UHFFFAOYSA-N hexadecanoyl chloride Chemical compound CCCCCCCCCCCCCCCC(Cl)=O ARBOVOVUTSQWSS-UHFFFAOYSA-N 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 150000002990 phenothiazines Chemical class 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7239673A FR2205317B2 (enrdf_load_stackoverflow) | 1972-11-09 | 1972-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL43544A true IL43544A (en) | 1976-05-31 |
Family
ID=9106882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43544A IL43544A (en) | 1972-11-09 | 1973-11-01 | 10(3-(4-(2-hydroxyethoxy)-4-alkyl)piperidino)-propyl-2-trifluoromethyl-phenothiazine derivatives,process for preparing them and pharmaceutical compositions containing them |
Country Status (10)
-
1972
- 1972-11-09 FR FR7239673A patent/FR2205317B2/fr not_active Expired
-
1973
- 1973-11-01 IL IL43544A patent/IL43544A/en unknown
- 1973-11-08 AU AU62309/73A patent/AU6230973A/en not_active Expired
- 1973-11-08 ES ES420360A patent/ES420360A2/es not_active Expired
- 1973-11-08 BE BE137538A patent/BE807072R/xx active
- 1973-11-09 NL NL7315410A patent/NL7315410A/xx not_active Application Discontinuation
- 1973-11-09 GB GB5217173A patent/GB1393490A/en not_active Expired
- 1973-11-09 ZA ZA738627A patent/ZA738627B/xx unknown
- 1973-11-09 DE DE2356168A patent/DE2356168A1/de not_active Withdrawn
- 1973-11-09 JP JP48125562A patent/JPS4993376A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU6230973A (en) | 1975-05-08 |
| JPS4993376A (enrdf_load_stackoverflow) | 1974-09-05 |
| ES420360A2 (es) | 1977-07-01 |
| FR2205317B2 (enrdf_load_stackoverflow) | 1975-11-28 |
| NL7315410A (enrdf_load_stackoverflow) | 1974-05-13 |
| BE807072R (fr) | 1974-05-08 |
| FR2205317A2 (enrdf_load_stackoverflow) | 1974-05-31 |
| DE2356168A1 (de) | 1974-05-22 |
| GB1393490A (en) | 1975-05-07 |
| ZA738627B (en) | 1974-11-27 |
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