IL42843A - Acid H1-tetrazole-acetic acid and esters and processes for their preparation - Google Patents
Acid H1-tetrazole-acetic acid and esters and processes for their preparationInfo
- Publication number
- IL42843A IL42843A IL42843A IL4284373A IL42843A IL 42843 A IL42843 A IL 42843A IL 42843 A IL42843 A IL 42843A IL 4284373 A IL4284373 A IL 4284373A IL 42843 A IL42843 A IL 42843A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- alkali metal
- formula
- tetrazole
- alkyl
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title claims abstract 10
- 238000000034 method Methods 0.000 title claims 9
- GRWAIJBHBCCLGS-UHFFFAOYSA-N 2-(tetrazol-1-yl)acetic acid Chemical compound OC(=O)CN1C=NN=N1 GRWAIJBHBCCLGS-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 17
- -1 hydrocarbon radical Chemical class 0.000 claims abstract 13
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract 9
- 239000002253 acid Substances 0.000 claims abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 7
- 150000007513 acids Chemical class 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 5
- 239000001257 hydrogen Substances 0.000 claims abstract 5
- 125000003944 tolyl group Chemical group 0.000 claims abstract 4
- 125000005023 xylyl group Chemical group 0.000 claims abstract 4
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical compound [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims abstract 3
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 claims abstract 2
- PPXUUPXQWDQNGO-UHFFFAOYSA-N 2-azidoacetic acid Chemical compound OC(=O)CN=[N+]=[N-] PPXUUPXQWDQNGO-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000001476 alcoholic effect Effects 0.000 claims abstract 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 2
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 claims abstract 2
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- BUYJAQOVJGKBEZ-UHFFFAOYSA-N 2-(5-ethoxycarbonyltetrazol-1-yl)acetic acid Chemical compound CCOC(=O)C1=NN=NN1CC(O)=O BUYJAQOVJGKBEZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- MSMGXWFHBSCQFB-UHFFFAOYSA-N ethyl cyanoformate Chemical compound CCOC(=O)C#N MSMGXWFHBSCQFB-UHFFFAOYSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- QQULZKDKXRNHNB-UHFFFAOYSA-N 1-(carboxymethyl)tetrazole-5-carboxylic acid Chemical compound OC(=O)CN1N=NN=C1C(O)=O QQULZKDKXRNHNB-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- GJQBHOAJJGIPRH-UHFFFAOYSA-N benzoyl cyanide Chemical compound N#CC(=O)C1=CC=CC=C1 GJQBHOAJJGIPRH-UHFFFAOYSA-N 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- UNDCGJBEVRCWCU-UHFFFAOYSA-N ethyl 2-(5-benzoyltetrazol-1-yl)acetate Chemical compound CCOC(=O)CN1N=NN=C1C(=O)C1=CC=CC=C1 UNDCGJBEVRCWCU-UHFFFAOYSA-N 0.000 claims 1
- HVJJYOAPXBPQQV-UHFFFAOYSA-N ethyl 2-azidoacetate Chemical compound CCOC(=O)CN=[N+]=[N-] HVJJYOAPXBPQQV-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 4
- 229930195733 hydrocarbon Natural products 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical compound C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
- 150000001264 acyl cyanides Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28062572A | 1972-08-14 | 1972-08-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42843A0 IL42843A0 (en) | 1976-01-30 |
| IL42843A true IL42843A (en) | 1976-12-31 |
Family
ID=23073908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42843A IL42843A (en) | 1972-08-14 | 1973-07-27 | Acid H1-tetrazole-acetic acid and esters and processes for their preparation |
Country Status (26)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854015B2 (de) * | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Herstellung von !H-TetrazoI-1-essigsauren und bestimmter Ester derselben |
| WO2010103783A1 (ja) * | 2009-03-11 | 2010-09-16 | 日本曹達株式会社 | １－アルキル－５－ベンゾイル－１ｈ－テトラゾール誘導体の製造方法 |
| CN114085193A (zh) * | 2021-11-20 | 2022-02-25 | 九江中星医药化工有限公司 | 一种水相法制备1h-四氮唑乙酸及其衍生物的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (enrdf_load_stackoverflow) * |
-
1973
- 1973-07-25 IE IE1268/73A patent/IE37949B1/xx unknown
- 1973-07-25 ZA ZA00735075A patent/ZA735075B/xx unknown
- 1973-07-26 AU AU58575/73A patent/AU476519B2/en not_active Expired
- 1973-07-27 IL IL42843A patent/IL42843A/en unknown
- 1973-08-02 CA CA177,995A patent/CA998397A/en not_active Expired
- 1973-08-03 PH PH14880A patent/PH10552A/en unknown
- 1973-08-07 YU YU02148/73A patent/YU36513B/xx unknown
- 1973-08-09 DE DE19732340409 patent/DE2340409A1/de active Granted
- 1973-08-10 HU HUEI490A patent/HU166844B/hu unknown
- 1973-08-10 AT AT703773A patent/AT329555B/de not_active IP Right Cessation
- 1973-08-10 BE BE1005292A patent/BE803520A/xx unknown
- 1973-08-13 SU SU7301955734A patent/SU576935A3/ru active
- 1973-08-13 PL PL1973164647A patent/PL89385B1/pl unknown
- 1973-08-13 GB GB3813273A patent/GB1435809A/en not_active Expired
- 1973-08-13 SE SE7311051A patent/SE402913B/xx unknown
- 1973-08-13 ES ES417837A patent/ES417837A1/es not_active Expired
- 1973-08-13 KR KR7301319A patent/KR780000071B1/ko not_active Expired
- 1973-08-14 RO RO7375793A patent/RO73460A/ro unknown
- 1973-08-14 BG BG024317A patent/BG21220A3/xx unknown
- 1973-08-14 FR FR7329649A patent/FR2196336B1/fr not_active Expired
- 1973-08-14 JP JP48091225A patent/JPS5821628B2/ja not_active Expired
- 1973-08-14 DD DD172890A patent/DD110272A5/xx unknown
- 1973-08-14 CH CH1171373A patent/CH588475A5/xx not_active IP Right Cessation
- 1973-08-14 CS CS7300005736A patent/CS179425B2/cs unknown
- 1973-08-14 NL NLAANVRAGE7311222,A patent/NL179380C/xx not_active IP Right Cessation
- 1973-08-14 AR AR249586A patent/AR195626A1/es active
Also Published As
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