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Expired
Application number
GB20987/46A
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Eli Lilly and Co
Original Assignee
Eli Lilly and Co
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Filing date
Publication date
Application filed by Eli Lilly and CofiledCriticalEli Lilly and Co
Publication of GB613489ApublicationCriticalpatent/GB613489A/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
The method for the production of penicillin claimed in Specification 613,488 is modified by replacing the phenylacetyl hydrolysate or a salt thereof of the culture medium by a compound having the formula <FORM:0613489/IV(b)/1> and/or the salts and lower alkyl esters thereof, wherein R represents hydrogen or a methyl or ethyl radical and R1 represents a methyl or ethyl radical. These compounds may be prepared by adding phenylacetyl chloride to an alkaline solution of the appropriate amine, filtering, acidifying and then purifying. In examples: (1) N-phenyl acetyl valine is prepared from valine and the product resolved by means of brucine to obtain the l-derivative; (2) the methyl ester of N-phenylacetyl isoleucine is obtained from isoleucine methyl ester hydrochloride and (3) a -amino-n-butyric acid is converted to phenylacetyl a -amino n-butyric acid. N-Phenyl acetyl b ,b -diethylalanine and the corresponding sodium, potassium, magnesium, ammonium and substituted ammonium salts are also specified. Specification 586,930, [Group VI], is referred to.
GB20987/46A1945-08-241946-07-12Improvements in process and culture medium for the production of penicillin
ExpiredGB613489A
(en)
Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof