GB613489A - Improvements in process and culture medium for the production of penicillin - Google Patents

Improvements in process and culture medium for the production of penicillin

Info

Publication number
GB613489A
GB613489A GB20987/46A GB2098746A GB613489A GB 613489 A GB613489 A GB 613489A GB 20987/46 A GB20987/46 A GB 20987/46A GB 2098746 A GB2098746 A GB 2098746A GB 613489 A GB613489 A GB 613489A
Authority
GB
United Kingdom
Prior art keywords
phenylacetyl
methyl
penicillin
culture medium
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20987/46A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB613489A publication Critical patent/GB613489A/en
Expired legal-status Critical Current

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Abstract

The method for the production of penicillin claimed in Specification 613,488 is modified by replacing the phenylacetyl hydrolysate or a salt thereof of the culture medium by a compound having the formula <FORM:0613489/IV(b)/1> and/or the salts and lower alkyl esters thereof, wherein R represents hydrogen or a methyl or ethyl radical and R1 represents a methyl or ethyl radical. These compounds may be prepared by adding phenylacetyl chloride to an alkaline solution of the appropriate amine, filtering, acidifying and then purifying. In examples: (1) N-phenyl acetyl valine is prepared from valine and the product resolved by means of brucine to obtain the l-derivative; (2) the methyl ester of N-phenylacetyl isoleucine is obtained from isoleucine methyl ester hydrochloride and (3) a -amino-n-butyric acid is converted to phenylacetyl a -amino n-butyric acid. N-Phenyl acetyl b ,b -diethylalanine and the corresponding sodium, potassium, magnesium, ammonium and substituted ammonium salts are also specified. Specification 586,930, [Group VI], is referred to.
GB20987/46A 1945-08-24 1946-07-12 Improvements in process and culture medium for the production of penicillin Expired GB613489A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US613489XA 1945-08-24 1945-08-24

Publications (1)

Publication Number Publication Date
GB613489A true GB613489A (en) 1948-11-29

Family

ID=22035207

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20987/46A Expired GB613489A (en) 1945-08-24 1946-07-12 Improvements in process and culture medium for the production of penicillin

Country Status (1)

Country Link
GB (1) GB613489A (en)

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