IE37949B1 - 1 h-tetrazole-1-acetate esters and acids and processes therefor - Google Patents
1 h-tetrazole-1-acetate esters and acids and processes thereforInfo
- Publication number
- IE37949B1 IE37949B1 IE1268/73A IE126873A IE37949B1 IE 37949 B1 IE37949 B1 IE 37949B1 IE 1268/73 A IE1268/73 A IE 1268/73A IE 126873 A IE126873 A IE 126873A IE 37949 B1 IE37949 B1 IE 37949B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkali metal
- radical
- acids
- hydrocarbon
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1435809 1 - H - Tetrazole - -1 - acetate esters and acids ELI LILLY & CO 13 Aug 1973 [14 Aug 1972] 38132/73 Heading C2C Novel tetrazolylacetate esters and acids having the general formula wherein R is a (C 1 -C 12 ) hydrocarbon radical free from aliphatic unsaturation, a (C 1 -C 12 ) hydrocarbon -O- radical free from aliphatic unsaturation or an -O- alkali metal radical; and R<SP>1</SP> is hydrogen, an alkali metal cation or a (C 1 -C 12 ) alkyl, (C 4 -C 8 ) cycloalkyl, phenyl, behzyl, p-nitrophenyl, p-nitrobenzyl, 2,2,2-trichloroethyl or phenacyl radical, as well those compounds of the above formula wherein R<SP>1</SP> may also be tolyl, xylyl or phenylethyl, are prepared by reacting an acyl cyanide of the formula (II) with an azidoacetic acid or ester thereof having the formula (III) at a temperature of from 80‹ to 135‹ C. The resultant tetrazolylacetate ester may be further reacted with either (a) an alcoholic alkali metal hydroxide to form the corresponding alkali metal salt, (b) a base to remove the 5-acyl substituent and form the alkali metal salt of 1-tetrazoleacetic acid, provided that R is a (C 1 -C 12 ) hydrocarbon radical, or (c) with an acid to remove the 5-acyl substituent and form the 1-tetrazoleacetic acid, provided that R is a (C 1 -C 12 ) hydrocarbon -O- radical.
[GB1435809A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28062572A | 1972-08-14 | 1972-08-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37949L IE37949L (en) | 1974-02-14 |
| IE37949B1 true IE37949B1 (en) | 1977-11-23 |
Family
ID=23073908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1268/73A IE37949B1 (en) | 1972-08-14 | 1973-07-25 | 1 h-tetrazole-1-acetate esters and acids and processes therefor |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5821628B2 (en) |
| KR (1) | KR780000071B1 (en) |
| AR (1) | AR195626A1 (en) |
| AT (1) | AT329555B (en) |
| AU (1) | AU476519B2 (en) |
| BE (1) | BE803520A (en) |
| BG (1) | BG21220A3 (en) |
| CA (1) | CA998397A (en) |
| CH (1) | CH588475A5 (en) |
| CS (1) | CS179425B2 (en) |
| DD (1) | DD110272A5 (en) |
| DE (1) | DE2340409A1 (en) |
| ES (1) | ES417837A1 (en) |
| FR (1) | FR2196336B1 (en) |
| GB (1) | GB1435809A (en) |
| HU (1) | HU166844B (en) |
| IE (1) | IE37949B1 (en) |
| IL (1) | IL42843A (en) |
| NL (1) | NL179380C (en) |
| PH (1) | PH10552A (en) |
| PL (1) | PL89385B1 (en) |
| RO (1) | RO73460A (en) |
| SE (1) | SE402913B (en) |
| SU (1) | SU576935A3 (en) |
| YU (1) | YU36513B (en) |
| ZA (1) | ZA735075B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854015B2 (en) * | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Process for the preparation of! H-TetrazoI-1-acetic acids and certain esters thereof |
| CN102341378B (en) | 2009-03-11 | 2015-09-09 | 日本曹达株式会社 | The preparation method of 1-alkyl-5-benzoyl-1H-TETRAZOLE derivative |
| CN114085193A (en) * | 2021-11-20 | 2022-02-25 | 九江中星医药化工有限公司 | Method for preparing 1H-tetrazoleacetic acid and derivatives thereof by aqueous phase method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (en) * |
-
1973
- 1973-07-25 ZA ZA00735075A patent/ZA735075B/en unknown
- 1973-07-25 IE IE1268/73A patent/IE37949B1/en unknown
- 1973-07-26 AU AU58575/73A patent/AU476519B2/en not_active Expired
- 1973-07-27 IL IL42843A patent/IL42843A/en unknown
- 1973-08-02 CA CA177,995A patent/CA998397A/en not_active Expired
- 1973-08-03 PH PH14880A patent/PH10552A/en unknown
- 1973-08-07 YU YU02148/73A patent/YU36513B/en unknown
- 1973-08-09 DE DE19732340409 patent/DE2340409A1/en active Granted
- 1973-08-10 AT AT703773A patent/AT329555B/en not_active IP Right Cessation
- 1973-08-10 BE BE1005292A patent/BE803520A/en unknown
- 1973-08-10 HU HUEI490A patent/HU166844B/hu unknown
- 1973-08-13 SE SE7311051A patent/SE402913B/en unknown
- 1973-08-13 GB GB3813273A patent/GB1435809A/en not_active Expired
- 1973-08-13 KR KR7301319A patent/KR780000071B1/en active
- 1973-08-13 SU SU7301955734A patent/SU576935A3/en active
- 1973-08-13 ES ES417837A patent/ES417837A1/en not_active Expired
- 1973-08-13 PL PL1973164647A patent/PL89385B1/pl unknown
- 1973-08-14 DD DD172890A patent/DD110272A5/xx unknown
- 1973-08-14 CS CS7300005736A patent/CS179425B2/en unknown
- 1973-08-14 AR AR249586A patent/AR195626A1/en active
- 1973-08-14 CH CH1171373A patent/CH588475A5/xx not_active IP Right Cessation
- 1973-08-14 JP JP48091225A patent/JPS5821628B2/en not_active Expired
- 1973-08-14 NL NLAANVRAGE7311222,A patent/NL179380C/en not_active IP Right Cessation
- 1973-08-14 BG BG024317A patent/BG21220A3/en unknown
- 1973-08-14 FR FR7329649A patent/FR2196336B1/fr not_active Expired
- 1973-08-14 RO RO7375793A patent/RO73460A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE37949L (en) | 1974-02-14 |
| PL89385B1 (en) | 1976-11-30 |
| YU214873A (en) | 1982-02-25 |
| PH10552A (en) | 1977-06-08 |
| ES417837A1 (en) | 1976-02-16 |
| KR780000071B1 (en) | 1978-03-30 |
| ZA735075B (en) | 1975-03-26 |
| HU166844B (en) | 1975-06-28 |
| YU36513B (en) | 1984-02-29 |
| DD110272A5 (en) | 1974-12-12 |
| CH588475A5 (en) | 1977-06-15 |
| CA998397A (en) | 1976-10-12 |
| CS179425B2 (en) | 1977-10-31 |
| AR195626A1 (en) | 1973-10-23 |
| BG21220A3 (en) | 1976-03-20 |
| JPS5821628B2 (en) | 1983-05-02 |
| IL42843A0 (en) | 1976-01-30 |
| FR2196336B1 (en) | 1977-02-25 |
| NL179380B (en) | 1986-04-01 |
| AT329555B (en) | 1976-05-25 |
| AU476519B2 (en) | 1976-09-23 |
| NL7311222A (en) | 1974-02-18 |
| JPS4975580A (en) | 1974-07-20 |
| GB1435809A (en) | 1976-05-19 |
| IL42843A (en) | 1976-12-31 |
| FR2196336A1 (en) | 1974-03-15 |
| ATA703773A (en) | 1975-08-15 |
| DE2340409C2 (en) | 1988-03-17 |
| DE2340409A1 (en) | 1974-02-28 |
| RO73460A (en) | 1982-09-09 |
| AU5857573A (en) | 1975-01-30 |
| SU576935A3 (en) | 1977-10-15 |
| BE803520A (en) | 1974-02-11 |
| NL179380C (en) | 1986-09-01 |
| SE402913B (en) | 1978-07-24 |
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