IL37984A - 2,4-diamino-5-benzylpyrimidine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

2,4-diamino-5-benzylpyrimidine derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL37984A
IL37984A IL37984A IL3798471A IL37984A IL 37984 A IL37984 A IL 37984A IL 37984 A IL37984 A IL 37984A IL 3798471 A IL3798471 A IL 3798471A IL 37984 A IL37984 A IL 37984A
Authority
IL
Israel
Prior art keywords
compound
general formula
group
preparing
guanidine
Prior art date
Application number
IL37984A
Other versions
IL37984A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL37984A0 publication Critical patent/IL37984A0/en
Publication of IL37984A publication Critical patent/IL37984A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (1)

1. A compound of general formula wherein and are the same or different alkyl groups each having from 2 to carbon atoms and wherein R 2 is an alkyl alko y group having from 1 to carbon a pharmaceuticall acceptable salt 1 A comp0und as claimed in claim wherein R is a or ethoxy A compound as claimed in claim 1 wherein is an ethyl A compound as claimed in any one of the preceding claims 1 wherei R and R are A as in any one of the preceding claims Ί wherein R are ethyl 4 0 1 A compound of general formula as claimed in claim 1 substantially as herein described with reference to any one of the foregoing 3 A method of preparing compound of general formula as claimed in any one of the preceding claims comprises reacting guanidine with a compound of general formula wherein R R and R are as defined any one of the preceding claims and X and Y taken together represent an additional bond when Z the group is an aromatic amino group wherein R and cannot both be a hydrogen or an alkoxy or or X is a hydrogen atom when Y and Z represents alkoxy group or taken together an alkylene dioxy t A method of preparing a compound of general formula as claimed in Claim wherein guanidine is reacted with a compound of general formula wherein X and Y represent an additional bond and Z represents a morpholino or anilino group which comprises carrying out the reaction in a which is an alkanol containin from 1 to carbon atoms at elevated 15 13 14 A method according to claim or the reaction guanidine with the of general formula is carried out using guanidine in the of the carbonate in the presence of a polar aprotic 16 A method of preparing a compound of formula as defined in any one of claims 1 and J8 or wherein a comp wherein R and R are as defined in any one the preceding Claims 1 to 4 and 6 or 7 and wherein L is a hydrogen atom or is an or aralkylthio such as having up to 12 carbon is reacted with an alkylating agent of formula R Q wherein Q is a reactive atom or group and wherein 2 R is an appropriate alkyl and in the case where is an alkylthio or aralkylthio removin the alkylthio or aralkylthio group by hydrogenolysis 17 A method as claimed in Claim of preparing compounds of formula substantially as hereinbefore described with to one of c of preparing of substantially to any of A of by of A which of or a salt claimed o o of the oceding Claims 1 12 19 A p claimed 20 a ouch as in as with to insufficientOCRQuality
IL37984A 1970-10-22 1971-10-21 2,4-diamino-5-benzylpyrimidine derivatives,their preparation and pharmaceutical compositions containing them IL37984A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB963871*[A GB1375162A (en) 1970-10-22 1970-10-22
GB963871 1971-04-16
GB4749171 1971-10-12

Publications (2)

Publication Number Publication Date
IL37984A0 IL37984A0 (en) 1971-12-29
IL37984A true IL37984A (en) 1976-03-31

Family

ID=27255400

Family Applications (2)

Application Number Title Priority Date Filing Date
IL37984A IL37984A (en) 1970-10-22 1971-10-21 2,4-diamino-5-benzylpyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL45422A IL45422A (en) 1970-10-22 1971-10-21 Alpha-(3,4,5-trisubstituted benzyl)-acrylonitriles and propionitriles and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL45422A IL45422A (en) 1970-10-22 1971-10-21 Alpha-(3,4,5-trisubstituted benzyl)-acrylonitriles and propionitriles and their preparation

Country Status (20)

Country Link
JP (2) JPS5536662B1 (en)
AR (3) AR192588A1 (en)
AT (1) AT319948B (en)
BE (1) BE774281A (en)
BG (4) BG20364A3 (en)
CA (1) CA967158A (en)
CH (3) CH568302A5 (en)
DD (1) DD100877A5 (en)
DK (1) DK132174C (en)
ES (1) ES396219A1 (en)
FI (1) FI56175C (en)
FR (1) FR2111769B1 (en)
GB (1) GB1375162A (en)
IE (1) IE37452B1 (en)
IL (2) IL37984A (en)
LU (1) LU64129A1 (en)
MC (1) MC894A1 (en)
NL (1) NL175178C (en)
SE (2) SE384505B (en)
ZM (1) ZM14971A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792096A (en) * 1971-12-01 1973-05-30 Hoffmann La Roche NEW BENZYLPYRIMIDINES
FR2397407A2 (en) * 1977-07-11 1979-02-09 Dick Pierre 2,4-DIAMINO PYRIMIDINE DERIVATIVES AND THEIR SOLUTION IN ASSOCIATION WITH SULFAMIDS
EP0006987A1 (en) * 1978-05-24 1980-01-23 The Wellcome Foundation Limited 2,4-Diamino-5-benzylpyrimidines, especially for the treatment of microbial infections, pharmaceutical compositions containing these compounds and processes for preparing these compounds
JPS61156909A (en) * 1984-12-27 1986-07-16 Matsushita Electric Ind Co Ltd Current mirror circuit
JPS62145907A (en) * 1985-12-20 1987-06-30 Hitachi Ltd transistor circuit
TWI392678B (en) 2004-03-26 2013-04-11 Dainippon Sumitomo Pharma Co 9-substituted-8-oxoadenine compound
US8138172B2 (en) 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
EP2139894B1 (en) 2007-03-19 2011-10-26 AstraZeneca AB 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
JP5480637B2 (en) 2007-03-19 2014-04-23 アストラゼネカ・アクチエボラーグ 9-Substituted-8-oxo-adenine compounds as TOLL-like receptor (TLR7) modulators
US8044056B2 (en) 2007-03-20 2011-10-25 Dainippon Sumitomo Pharma Co., Ltd. Adenine compound
PE20091236A1 (en) * 2007-11-22 2009-09-16 Astrazeneca Ab PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7
UY31531A1 (en) 2007-12-17 2009-08-03 SALTS DERIVED FROM 8-OXOADENINE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THERAPY AS TOLL TYPE RECEIVER MODULATORS (TLR)
GB0908772D0 (en) 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
JP5913093B2 (en) 2009-05-21 2016-04-27 アストラゼネカ アクチボラグ Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
ES2575688T3 (en) 2010-12-16 2016-06-30 Sumitomo Dainippon Pharma Co., Ltd. Imidazo [4,5-c] quinolin-1-yl derivative useful in therapy
JP5978226B2 (en) 2010-12-17 2016-08-24 大日本住友製薬株式会社 Purine derivatives
AU2013261267B2 (en) 2012-05-18 2017-06-29 Sumitomo Pharma Co., Ltd. Carboxylic acid compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE710100A (en) * 1967-02-02 1968-07-30
JPS511716A (en) * 1974-06-25 1976-01-08 Toray Industries HORIESUTERUMARUCHIFUIRAMENTONO SEIHO

Also Published As

Publication number Publication date
JPS5536662B1 (en) 1980-09-22
AR192588A1 (en) 1973-02-28
FR2111769A1 (en) 1972-06-09
NL175178C (en) 1984-10-01
ES396219A1 (en) 1975-09-16
CA967158A (en) 1975-05-06
NL7114494A (en) 1972-04-25
JPS53135991A (en) 1978-11-28
GB1375162A (en) 1974-11-27
FI56175B (en) 1979-08-31
DK132174B (en) 1975-11-03
ZM14971A1 (en) 1972-07-21
DD100877A5 (en) 1973-10-12
AR192802A1 (en) 1973-03-14
AR192803A1 (en) 1973-03-14
MC894A1 (en) 1972-06-22
NL175178B (en) 1984-05-01
IE37452B1 (en) 1977-08-03
IE37452L (en) 1972-04-22
FR2111769B1 (en) 1974-10-18
CH568302A5 (en) 1975-10-31
AT319948B (en) 1975-01-10
CH568301A5 (en) 1975-10-31
BG21406A3 (en) 1976-05-20
DK132174C (en) 1976-03-29
IL37984A0 (en) 1971-12-29
LU64129A1 (en) 1972-06-28
BE774281A (en) 1972-04-21
SE409705B (en) 1979-09-03
BG20797A3 (en) 1975-12-20
BG20365A3 (en) 1975-11-05
IL45422A (en) 1976-03-31
BG20364A3 (en) 1975-11-05
SE384505B (en) 1976-05-10
FI56175C (en) 1979-12-10
CH582681A5 (en) 1976-12-15

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