IL37331A - Process for producing 3-(morpholino-alkoxy)-1h and 2h indazoles and pharmaceutical compositions containing the same - Google Patents
Process for producing 3-(morpholino-alkoxy)-1h and 2h indazoles and pharmaceutical compositions containing the sameInfo
- Publication number
- IL37331A IL37331A IL37331A IL3733171A IL37331A IL 37331 A IL37331 A IL 37331A IL 37331 A IL37331 A IL 37331A IL 3733171 A IL3733171 A IL 3733171A IL 37331 A IL37331 A IL 37331A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- compound
- morpholino
- hydrochloride
- residue
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 6
- 238000001704 evaporation Methods 0.000 claims 6
- 229910052700 potassium Inorganic materials 0.000 claims 6
- 239000011591 potassium Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 3
- 230000029936 alkylation Effects 0.000 claims 3
- 238000005804 alkylation reaction Methods 0.000 claims 3
- 239000012230 colorless oil Substances 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 3
- 239000012259 ether extract Substances 0.000 claims 3
- 230000008020 evaporation Effects 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000003208 petroleum Substances 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000012299 nitrogen atmosphere Substances 0.000 claims 2
- UFNPJQRQWKZJNL-UHFFFAOYSA-N 1,2,4,5,6,7-hexahydroindazol-3-one Chemical compound C1CCCC2=C1NNC2=O UFNPJQRQWKZJNL-UHFFFAOYSA-N 0.000 claims 1
- SWEICGMKXPNXNU-UHFFFAOYSA-N 1,2-dihydroindazol-3-one Chemical compound C1=CC=C2C(O)=NNC2=C1 SWEICGMKXPNXNU-UHFFFAOYSA-N 0.000 claims 1
- ZAPMTSHEXFEPSD-UHFFFAOYSA-N 4-(2-chloroethyl)morpholine Chemical compound ClCCN1CCOCC1 ZAPMTSHEXFEPSD-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000012298 atmosphere Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960003750 ethyl chloride Drugs 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702035494 DE2035494C (de) | 1970-07-17 | Ein neues Derivat von 2H Inda zolon 3, deren Hydrobromid und Arzneimittel aus diesen Verbindungen | |
| DE19712134592 DE2134592C3 (de) | 1971-07-10 | 1971-07-10 | Verfahren zur Herstellung von 3-(beta-Morpholinoäthoxy)-lH-indazol,3-(gamma,Morpholinopropoxy)-1 H-indazol und 3-(beta-Morpholinoäthoxy)-4,5,6,7tetrahydro-2H-indazol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL37331A0 IL37331A0 (en) | 1972-01-27 |
| IL37331A true IL37331A (en) | 1976-12-31 |
Family
ID=25759450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL37331A IL37331A (en) | 1970-07-17 | 1971-07-18 | Process for producing 3-(morpholino-alkoxy)-1h and 2h indazoles and pharmaceutical compositions containing the same |
Country Status (9)
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428634A (en) * | 1965-03-13 | 1969-02-18 | Acraf | 3-tertiary amino alkoxy-1-hydrocarbon indazoles |
-
1971
- 1971-07-16 DK DK352071AA patent/DK129845B/da not_active IP Right Cessation
- 1971-07-16 NL NLAANVRAGE7109842,A patent/NL169469C/xx not_active IP Right Cessation
- 1971-07-16 CH CH1050571A patent/CH554889A/xx not_active IP Right Cessation
- 1971-07-16 SE SE7109242A patent/SE379767B/xx unknown
- 1971-07-17 ES ES393379A patent/ES393379A1/es not_active Expired
- 1971-07-18 IL IL37331A patent/IL37331A/en unknown
- 1971-07-19 FR FR7126341A patent/FR2100928A1/fr active Granted
- 1971-07-19 CA CA118,519A patent/CA957370A/en not_active Expired
- 1971-07-19 AU AU31422/71A patent/AU474762B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE379767B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-10-20 |
| CH554889A (de) | 1974-10-15 |
| FR2100928B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-02-07 |
| DK129845B (da) | 1974-11-25 |
| AU474762B2 (en) | 1976-08-05 |
| NL169469B (nl) | 1982-02-16 |
| AU3142271A (en) | 1973-01-25 |
| NL7109842A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-01-19 |
| NL169469C (nl) | 1982-07-16 |
| DK129845C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-05-12 |
| ES393379A1 (es) | 1974-09-16 |
| CA957370A (en) | 1974-11-05 |
| FR2100928A1 (en) | 1972-03-24 |
| IL37331A0 (en) | 1972-01-27 |
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