|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
WO1981001145A1
(en)
|
1979-10-18 |
1981-04-30 |
Univ Illinois |
Hydrolytic enzyme-activatible pro-drugs
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
GB8705477D0
(en)
|
1987-03-09 |
1987-04-15 |
Carlton Med Prod |
Drug delivery systems
|
|
US4975278A
(en)
|
1988-02-26 |
1990-12-04 |
Bristol-Myers Company |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
CA2103059C
(en)
|
1991-06-14 |
2005-03-22 |
Paul J. Carter |
Method for making humanized antibodies
|
|
CA2140933A1
(en)
|
1992-08-21 |
1994-02-22 |
Paula M. Jardieu |
Method for treating an lfa-1 mediated disorder
|
|
RU2139731C1
(ru)
|
1992-11-13 |
1999-10-20 |
Айдек Фармасьютикалс Корпорейшн (US |
Способ лечения, антитела, гибридома
|
|
EP0820299B1
(en)
|
1995-02-06 |
2002-04-24 |
Genetics Institute, Inc. |
Formulations for il-12
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US6037454A
(en)
|
1996-11-27 |
2000-03-14 |
Genentech, Inc. |
Humanized anti-CD11a antibodies
|
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
|
CO4810232A1
(es)
|
1997-07-25 |
1999-06-30 |
Schering Corp |
Citoquinas de mamiferos y sus secuencias codificadoras
|
|
US6060284A
(en)
|
1997-07-25 |
2000-05-09 |
Schering Corporation |
DNA encoding interleukin-B30
|
|
AU2661199A
(en)
|
1998-02-06 |
1999-08-23 |
Schering Corporation |
Mammalian receptor proteins; related reagents and methods
|
|
ATE474849T1
(de)
|
1998-04-14 |
2010-08-15 |
Chugai Pharmaceutical Co Ltd |
Neues cytokinartiges protein
|
|
US6367172B2
(en)
|
1999-07-02 |
2002-04-09 |
Bbc International Ltd. |
Flex sole
|
|
US7090847B1
(en)
|
1999-09-09 |
2006-08-15 |
Schering Corporation |
Mammalian cytokines; related reagents and methods
|
|
DK1287130T3
(da)
|
2000-05-10 |
2008-09-01 |
Schering Corp |
Cytokinreceptorunderenhedproteiner fra pattedyr, tilhörende reagenser og fremgangsmåder
|
|
US7422743B2
(en)
|
2000-05-10 |
2008-09-09 |
Schering Corporation |
Mammalian receptor protein DCRS5;methods of treatment
|
|
WO2003034818A1
(en)
|
2001-10-24 |
2003-05-01 |
Chugai Seiyaku Kabushiki Kaisha |
Sgrf genetically modified nonhuman animal
|
|
EP1441589B1
(en)
|
2001-11-08 |
2012-05-09 |
Abbott Biotherapeutics Corp. |
Stable liquid pharmaceutical formulation of igg antibodies
|
|
KR101053412B1
(ko)
|
2002-10-30 |
2011-08-01 |
제넨테크, 인크. |
Ｉｌ―１７ 생성의 억제
|
|
EP1587834B1
(en)
|
2002-12-23 |
2011-07-06 |
Schering Corporation |
Uses of il-23 mammalian cytokine; related reagents
|
|
WO2004071517A2
(en)
|
2003-02-06 |
2004-08-26 |
Schering Corporation |
Uses of il-23 related reagents
|
|
TWI357336B
(en)
|
2003-03-10 |
2012-02-01 |
Schering Corp |
Uses of il-23 agonists and antagonists; related re
|
|
US7413894B2
(en)
|
2003-07-01 |
2008-08-19 |
University Of Virginia Patent Foundation |
TAG-1 and TAG-2 proteins and uses thereof
|
|
US8277810B2
(en)
|
2003-11-04 |
2012-10-02 |
Novartis Vaccines & Diagnostics, Inc. |
Antagonist anti-CD40 antibodies
|
|
CA2544948A1
(en)
|
2003-11-04 |
2005-05-19 |
Chiron Corporation |
Methods of therapy for cancers expressing the cd40 antigen
|
|
CA2544951A1
(en)
|
2003-11-04 |
2005-05-19 |
Chiron Corporation |
Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma
|
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
|
CN1942201B
(zh)
|
2004-02-17 |
2012-06-20 |
先灵公司 |
调节il-23活性的方法；相关试剂
|
|
US20050287593A1
(en)
|
2004-05-03 |
2005-12-29 |
Schering Corporation |
Use of cytokine expression to predict skin inflammation; methods of treatment
|
|
CN1993480A
(zh)
|
2004-05-03 |
2007-07-04 |
先灵公司 |
Il－17表达预测皮肤炎症的用途；治疗方法
|
|
EP1799700A4
(en)
|
2004-09-27 |
2009-02-11 |
Centocor Inc |
SRAGE MIMETIC BODIES, COMPOSITIONS, PROCESSES AND USES
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
TWI363091B
(en)
|
2004-12-20 |
2012-05-01 |
Schering Corp |
Uses of mammalian cytokine; related reagents
|
|
AU2006265898A1
(en)
|
2005-06-30 |
2007-01-11 |
Archemix Corp. |
Polynucleotides and polypeptides of the IL-12 family of cytokines
|
|
CA2613818C
(en)
|
2005-06-30 |
2013-08-27 |
Centocor, Inc. |
Anti-il-23 antibodies, compositions, methods and uses
|
|
CA2619052A1
(en)
|
2005-08-25 |
2007-03-01 |
Eli Lily And Company |
Anti-il-23 antibiodies
|
|
LT1931710T
(lt)
|
2005-08-31 |
2017-03-27 |
Merck Sharp & Dohme Corp. |
Rekombinantiniai anti-il-23 antikūnai
|
|
EP1933869B1
(en)
|
2005-09-01 |
2009-10-14 |
Schering Corporation |
Use of il-23 and il-17 antagonists to treat autoimmune ocular inflammatory disease
|
|
US20090270480A1
(en)
|
2005-12-28 |
2009-10-29 |
Bernard Amegadzie |
Markers and Methods for Assessing and Treating Psoriasis and Related Disorders
|
|
SI1971366T1
(sl)
|
2005-12-29 |
2014-10-30 |
Janssen Biotech, Inc. |
Humana protitelesa anti-il-23, sestavki, postopki in uporabe
|
|
US7910703B2
(en)
|
2006-03-10 |
2011-03-22 |
Zymogenetics, Inc. |
Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
|
|
US20080311043A1
(en)
|
2006-06-08 |
2008-12-18 |
Hoffman Rebecca S |
Uses and compositions for treatment of psoriatic arthritis
|
|
EP2044118A2
(en)
|
2006-06-13 |
2009-04-08 |
Zymogenetics, Inc. |
Il-17 and il-23 antagonists and methods of using the same
|
|
US20080031882A1
(en)
|
2006-06-19 |
2008-02-07 |
Liang Spencer C |
Methods of modulating IL-22 and IL-17
|
|
JP5419709B2
(ja)
|
2007-01-09 |
2014-02-19 |
ワイス・エルエルシー |
抗ｉｌ−１３抗体製剤およびその使用
|
|
TWI426918B
(zh)
|
2007-02-12 |
2014-02-21 |
Merck Sharp & Dohme |
Ｉｌ-２３拮抗劑於治療感染之用途
|
|
US20080200591A1
(en)
|
2007-02-15 |
2008-08-21 |
Isao Noda |
Melt Processable Reactive Pellets Capable of Forming Ester Condensates and Process for Forming Melt Processable Reactive Pellets
|
|
CN101605532A
(zh)
|
2007-02-16 |
2009-12-16 |
惠氏公司 |
含有山梨糖醇的蛋白质调配物
|
|
MX2009009080A
(es)
|
2007-02-23 |
2009-11-02 |
Schering Corp |
Anticuerpos anti-interleucina-23p19 manipulados por ingenieria genetica.
|
|
RS58098B1
(sr)
|
2007-02-23 |
2019-02-28 |
Merck Sharp & Dohme |
Anti-il-23p19 antitela proizvedena genetičkim inženjerstvom
|
|
EP2056838B1
(en)
|
2007-02-28 |
2013-09-25 |
Merck Sharp & Dohme Corp. |
Combination therapy for treatment of immune disorders
|
|
ES2525488T3
(es)
|
2007-09-04 |
2014-12-23 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Deleciones en el dominio II de la exotoxina A de pseudomonas que reducen la toxicidad inespecífica
|
|
AR068723A1
(es)
|
2007-10-05 |
2009-12-02 |
Glaxo Group Ltd |
Proteina que se une a antigenos que se une a il-23 humana y sus usos
|
|
EP2212442A1
(en)
|
2007-10-26 |
2010-08-04 |
Galderma Research & Development |
Non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis method thereof
|
|
CA2607771A1
(en)
|
2007-11-01 |
2009-05-01 |
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence |
Humanized anti-venezuelan equine encephalitis virus recombinant antibody
|
|
SG186607A1
(en)
|
2007-11-30 |
2013-01-30 |
Abbott Lab |
Protein formulations and methods of making same
|
|
WO2009082624A2
(en)
|
2007-12-10 |
2009-07-02 |
Zymogenetics, Inc. |
Antagonists of il-17a, il-17f, and il-23 and methods of using the same
|
|
WO2010017598A1
(en)
|
2008-08-14 |
2010-02-18 |
Arana Therapeutics Limited |
Anti-il-12/il-23 antibodies
|
|
WO2010027766A1
(en)
|
2008-08-27 |
2010-03-11 |
Schering Corporation |
Lyophilized formulatons of engineered anti-il-23p19 antibodies
|
|
AU2009320061A1
(en)
|
2008-11-03 |
2010-06-03 |
Merck Sharp & Dohme Corp. |
Inflammatory bowel disease biomarkers and related methods of treatment
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
WO2010062896A1
(en)
|
2008-11-28 |
2010-06-03 |
Abbott Laboratories |
Stable antibody compositions and methods for stabilizing same
|
|
EP2414393A1
(en)
|
2009-04-01 |
2012-02-08 |
Glaxo Group Limited |
Anti-il-23 immunoglobulins
|
|
WO2010115092A2
(en)
|
2009-04-02 |
2010-10-07 |
The Johns Hopkins University |
Compositions and methods for treating or preventing inflammatory bowel disease and colon cancer
|
|
US20120269765A1
(en)
|
2009-07-24 |
2012-10-25 |
Garcia K Christopher |
Cytokine compositions and methods of use thereof
|
|
JO3244B1
(ar)
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
EP2504031A4
(en)
|
2009-11-24 |
2013-06-26 |
Alderbio Holdings Llc |
ANTI-IL-6 ANTIBODIES AND THEIR USE
|
|
EP2506785A4
(en)
|
2009-12-02 |
2014-10-15 |
Spartek Medical Inc |
LOW PROFILE SPINAL PROSTHESIS WITH A BONE ANCHOR WITH A HINGED BAR AND A VERTICAL TOWER ROD
|
|
GB201013975D0
(en)
|
2010-08-20 |
2010-10-06 |
Imp Innovations Ltd |
Method of treating desease
|
|
CA2790329A1
(en)
|
2010-02-18 |
2011-08-25 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind il-23
|
|
CA2789061A1
(en)
|
2010-02-26 |
2011-09-01 |
Henrik Parshad |
Stable antibody containing compositions
|
|
RU2626512C2
(ru)
|
2010-03-01 |
2017-07-28 |
Цитодин, Инк. |
Концентрированные белковые фармацевтические составы и их применение
|
|
ES2692152T3
(es)
|
2010-06-15 |
2018-11-30 |
Celgene Corporation |
Biomarcadores para el tratamiento de la psoriasis
|
|
US20110311527A1
(en)
|
2010-06-16 |
2011-12-22 |
Allergan, Inc. |
IL23p19 ANTIBODY INHIBITOR FOR TREATING OCULAR AND OTHER CONDITIONS
|
|
EP2596022A4
(en)
|
2010-07-20 |
2014-11-05 |
Cephalon Australia Pty Ltd |
SPECIFIC ANTIBODIES ANTI-HETERODIMER IL-23
|
|
WO2012032181A2
(en)
|
2010-09-10 |
2012-03-15 |
Allozyne, Inc |
Novel antibody derivatives
|
|
HUE030916T2
(en)
*
|
2010-11-04 |
2017-06-28 |
Boehringer Ingelheim Int |
Anti-il-23 antibodies
|
|
GB201100282D0
(en)
|
2011-01-07 |
2011-02-23 |
Ucb Pharma Sa |
Biological methods
|
|
TW201309330A
(zh)
|
2011-01-28 |
2013-03-01 |
Abbott Lab |
包含糖基化抗體之組合物及其用途
|
|
WO2012104402A1
(en)
|
2011-02-04 |
2012-08-09 |
Ab Science |
Treatment of severe persitent asthma with masitinib
|
|
CA2871985C
(en)
|
2012-05-03 |
2023-10-10 |
Boehringer Ingelheim International Gmbh |
Anti-il-23p19 antibodies
|
|
EP2863951A1
(en)
|
2012-06-12 |
2015-04-29 |
Boehringer Ingelheim International GmbH |
Pharmaceutical formulation for a therapeutic antibody
|
|
ES2729603T3
(es)
|
2012-06-27 |
2019-11-05 |
Merck Sharp & Dohme |
Anticuerpos IL-23 antihumanos cristalinos
|
|
CN105209064A
(zh)
*
|
2013-03-15 |
2015-12-30 |
美国安进公司 |
使用抗il-23抗体治疗银屑病的方法
|
|
WO2014143540A1
(en)
|
2013-03-15 |
2014-09-18 |
Amgen Inc. |
Methods for treating crohn's disease using an anti-il23 antibody
|
|
KR20140119396A
(ko)
|
2013-03-29 |
2014-10-10 |
삼성전자주식회사 |
단백질 약물의 액상 제형
|
|
WO2016014775A1
(en)
|
2014-07-24 |
2016-01-28 |
Boehringer Ingelheim International Gmbh |
Biomarkers useful in the treatment of il-23a related diseases
|
|
AP2017009776A0
(en)
|
2014-09-03 |
2017-02-28 |
Boehringer Ingelheim Int |
Compound targeting il-23a and tnf-alpha and uses thereof
|
|
CN107206081A
(zh)
|
2015-02-04 |
2017-09-26 |
勃林格殷格翰国际有限公司 |
治疗炎性疾病的方法
|
|
SG11201708399WA
(en)
|
2015-04-14 |
2017-11-29 |
Boehringer Ingelheim Int |
Methods of treating diseases
|
|
PH12021552628A1
(en)
|
2015-07-23 |
2022-06-27 |
Boehringer Ingelheim Int |
Compound targeting il-23a and b-cell activating factor (baff) and uses thereof
|
|
TWI811716B
(zh)
|
2015-09-18 |
2023-08-11 |
德商百靈佳殷格翰國際股份有限公司 |
治療發炎性疾病之方法
|
|
EP3560956A3
(en)
|
2016-04-15 |
2020-01-01 |
Boehringer Ingelheim International GmbH |
Methods of treating inflammatory diseases
|
|
GB201612317D0
(en)
|
2016-07-15 |
2016-08-31 |
Philogen Spa |
Antibody compositions
|
|
WO2018033482A1
(en)
|
2016-08-17 |
2018-02-22 |
Boehringer Ingelheim International Gmbh |
Process for the preparation of highly concentrated liquid formulations containing biomolecules
|
|
EP3526252A2
(en)
|
2016-10-14 |
2019-08-21 |
Boehringer Ingelheim International GmbH |
Methods of treating diseases with il-23a antibody
|
|
WO2019246271A1
(en)
|
2018-06-20 |
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|
|
JP7090014B2
(ja)
*
|
2018-11-07 |
2022-06-23 |
株式会社ミツバ |
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|
|
TW202535466A
(zh)
|
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|
|
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(he)
|
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2025-04-01 |
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|