IL315043A - Humanized anti-tdp-43 binding molecules and uses thereof - Google Patents

Humanized anti-tdp-43 binding molecules and uses thereof

Info

Publication number
IL315043A
IL315043A IL315043A IL31504324A IL315043A IL 315043 A IL315043 A IL 315043A IL 315043 A IL315043 A IL 315043A IL 31504324 A IL31504324 A IL 31504324A IL 315043 A IL315043 A IL 315043A
Authority
IL
Israel
Prior art keywords
seq
tdp
chain variable
amino acid
variable region
Prior art date
Application number
IL315043A
Other languages
English (en)
Hebrew (he)
Inventor
Tariq Afroz
Romain Christian Ollier
Micka?L Marc Pascal Audrain
Original Assignee
Ac Immune Sa
Tariq Afroz
Romain Christian Ollier
Micka?L Marc Pascal Audrain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ac Immune Sa, Tariq Afroz, Romain Christian Ollier, Micka?L Marc Pascal Audrain filed Critical Ac Immune Sa
Publication of IL315043A publication Critical patent/IL315043A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL315043A 2022-02-16 2023-02-16 Humanized anti-tdp-43 binding molecules and uses thereof IL315043A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22157150 2022-02-16
EP22177361 2022-06-06
EP23152958 2023-01-23
EP23153165 2023-01-24
PCT/EP2023/053940 WO2023156549A1 (en) 2022-02-16 2023-02-16 Humanized anti-tdp-43 binding molecules and uses thereof

Publications (1)

Publication Number Publication Date
IL315043A true IL315043A (en) 2024-10-01

Family

ID=85239102

Family Applications (1)

Application Number Title Priority Date Filing Date
IL315043A IL315043A (en) 2022-02-16 2023-02-16 Humanized anti-tdp-43 binding molecules and uses thereof

Country Status (13)

Country Link
US (1) US20250145695A1 (https=)
EP (1) EP4479426A1 (https=)
JP (1) JP2025507569A (https=)
KR (1) KR20240150774A (https=)
AR (1) AR128540A1 (https=)
AU (1) AU2023221539A1 (https=)
CA (1) CA3243689A1 (https=)
CL (1) CL2024002383A1 (https=)
CR (1) CR20240378A (https=)
IL (1) IL315043A (https=)
MX (1) MX2024009948A (https=)
TW (1) TW202342519A (https=)
WO (1) WO2023156549A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11252156B2 (en) * 2012-05-31 2022-02-15 Ikonopedia, Inc. Secure data transmission
AU2024341632A1 (en) * 2023-09-15 2026-04-23 Prothena Biosciences Limited Compositions and methods of reducing immunogenicity and improving stability of antibodies
WO2025134068A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Antibody drug conjugates targeting proteinopathies, and uses thereof
WO2025186332A1 (en) 2024-03-05 2025-09-12 Ac Immune Sa Vectorized anti-tdp-43 antibodies
KR20260044274A (ko) * 2024-09-23 2026-04-02 주식회사 피플바이오 Tdp-43에 특이적으로 결합하는 항체 및 이의 용도

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Also Published As

Publication number Publication date
AR128540A1 (es) 2024-05-22
WO2023156549A1 (en) 2023-08-24
KR20240150774A (ko) 2024-10-16
TW202342519A (zh) 2023-11-01
AU2023221539A1 (en) 2024-08-22
JP2025507569A (ja) 2025-03-21
CL2024002383A1 (es) 2025-01-03
CR20240378A (es) 2024-10-03
MX2024009948A (es) 2024-08-22
CA3243689A1 (en) 2023-08-24
EP4479426A1 (en) 2024-12-25
US20250145695A1 (en) 2025-05-08

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