IL314890A - Polynucleotide libraries having controlled stoichiometry and synthesis thereof - Google Patents
Polynucleotide libraries having controlled stoichiometry and synthesis thereofInfo
- Publication number
- IL314890A IL314890A IL314890A IL31489024A IL314890A IL 314890 A IL314890 A IL 314890A IL 314890 A IL314890 A IL 314890A IL 31489024 A IL31489024 A IL 31489024A IL 314890 A IL314890 A IL 314890A
- Authority
- IL
- Israel
- Prior art keywords
- library
- polynucleotides
- double stranded
- stranded dna
- genome
- Prior art date
Links
- 108091033319 polynucleotide Proteins 0.000 title claims 13
- 102000040430 polynucleotide Human genes 0.000 title claims 13
- 239000002157 polynucleotide Substances 0.000 title claims 13
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 108020004414 DNA Proteins 0.000 claims 6
- 102000053602 DNA Human genes 0.000 claims 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 108700024394 Exon Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662424302P | 2016-11-18 | 2016-11-18 | |
| US201762548307P | 2017-08-21 | 2017-08-21 | |
| US201762558666P | 2017-09-14 | 2017-09-14 | |
| PCT/US2017/062391 WO2018094263A1 (en) | 2016-11-18 | 2017-11-17 | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL314890A true IL314890A (en) | 2024-10-01 |
Family
ID=62144787
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL314890A IL314890A (en) | 2016-11-18 | 2017-11-17 | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
| IL266681A IL266681B2 (en) | 2016-11-18 | 2017-11-17 | Polynucleotide libraries with controlled stoichiometry and their synthesis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL266681A IL266681B2 (en) | 2016-11-18 | 2017-11-17 | Polynucleotide libraries with controlled stoichiometry and their synthesis |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20180142289A1 (OSRAM) |
| EP (1) | EP3541973B1 (OSRAM) |
| JP (3) | JP2020504709A (OSRAM) |
| KR (1) | KR102569164B1 (OSRAM) |
| CN (1) | CN110382752A (OSRAM) |
| AU (2) | AU2017363204B2 (OSRAM) |
| CA (1) | CA3044057A1 (OSRAM) |
| GB (1) | GB2572877A (OSRAM) |
| IL (2) | IL314890A (OSRAM) |
| WO (1) | WO2018094263A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102122632B1 (ko) | 2013-08-05 | 2020-06-16 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| EP3350314A4 (en) | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| AU2017261189B2 (en) * | 2016-05-02 | 2023-02-09 | Becton, Dickinson And Company | Accurate molecular barcoding |
| GB2568444A (en) | 2016-08-22 | 2019-05-15 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| JP2020504709A (ja) * | 2016-11-18 | 2020-02-13 | ツイスト バイオサイエンス コーポレーション | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
| CN110366613A (zh) | 2016-12-16 | 2019-10-22 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| SG11201907713WA (en) | 2017-02-22 | 2019-09-27 | Twist Bioscience Corp | Nucleic acid based data storage |
| CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| KR102784398B1 (ko) | 2017-06-12 | 2025-03-19 | 트위스트 바이오사이언스 코포레이션 | 심리스 핵산 어셈블리를 위한 방법 |
| JP2020536504A (ja) | 2017-09-11 | 2020-12-17 | ツイスト バイオサイエンス コーポレーション | Ｇｐｃｒ結合タンパク質およびその合成 |
| KR102889470B1 (ko) | 2017-10-20 | 2025-11-21 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| WO2019136175A1 (en) | 2018-01-04 | 2019-07-11 | Twist Bioscience Corporation | Dna-based digital information storage |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| CN119708086A (zh) | 2018-12-26 | 2025-03-28 | 特韦斯特生物科学公司 | 高度准确的从头多核苷酸合成 |
| AU2020227802A1 (en) | 2019-02-26 | 2021-10-14 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| EP3930753A4 (en) | 2019-02-26 | 2023-03-29 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID LIBRARIES FOR GLP1 RECEPTOR |
| CN114729342A (zh) | 2019-06-21 | 2022-07-08 | 特韦斯特生物科学公司 | 基于条形码的核酸序列装配 |
| WO2021061829A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| AU2020355027A1 (en) | 2019-09-23 | 2022-04-21 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| WO2021092244A1 (en) * | 2019-11-06 | 2021-05-14 | Adaptive Biotechnologies Corporation | Synthetic strands for nucleic acid sequencing and related methods and systems |
| CN110853708B (zh) * | 2019-11-13 | 2022-03-08 | 上海仁东医学检验所有限公司 | 用于hla分型的核酸捕获探针的设计方法 |
| BR112022021789A2 (pt) | 2020-04-27 | 2023-03-07 | Twist Bioscience Corp | Bibliotecas de ácido nucléico variantes para coronavírus |
| EP4150110A4 (en) * | 2020-05-11 | 2024-06-26 | Personal Genome Diagnostics Inc. | SELECTIVE CAPTURE OF TARGET DNA SEQUENCES |
| CN115867672A (zh) * | 2020-05-28 | 2023-03-28 | 伊鲁米纳公司 | 比较具有不同特征的多核苷酸拷贝 |
| KR20230074151A (ko) | 2020-08-26 | 2023-05-26 | 트위스트 바이오사이언스 코포레이션 | Glp1r 변이체에 관한 방법 및 조성물 |
| WO2022086866A1 (en) | 2020-10-19 | 2022-04-28 | Twist Bioscience Corporation | Methods of synthesizing oligonucleotides using tethered nucleotides |
| CA3206018A1 (en) | 2021-01-21 | 2022-07-28 | Twist Bioscience Corporation | Methods and compositions relating to adenosine receptors |
| BE1029144B1 (fr) * | 2021-02-25 | 2022-09-20 | Oncodna | Méthode de caracterisation d'une tumeur à l'aide d'un séquençage ciblé |
| US12258406B2 (en) | 2021-03-24 | 2025-03-25 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| US12201857B2 (en) | 2021-06-22 | 2025-01-21 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| KR20240101677A (ko) | 2021-11-18 | 2024-07-02 | 트위스트 바이오사이언스 코포레이션 | Dickkopf-1 변이체 항체 및 사용 방법 |
| US12325739B2 (en) | 2022-01-03 | 2025-06-10 | Twist Bioscience Corporation | Bispecific SARS-CoV-2 antibodies and methods of use |
| CN116417071A (zh) * | 2023-04-07 | 2023-07-11 | 祥符实验室 | 一种dna数据存储的选择性访问方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| JP2005535283A (ja) * | 2001-11-13 | 2005-11-24 | ルビコン ゲノミクス インコーポレイテッド | ランダムフラグメント化により生成されたｄｎａ分子を用いたｄｎａ増幅および配列決定 |
| US9598737B2 (en) * | 2012-05-09 | 2017-03-21 | Longhorn Vaccines And Diagnostics, Llc | Next generation genomic sequencing methods |
| WO2010030683A1 (en) * | 2008-09-09 | 2010-03-18 | Rosetta Inpharmatics Llc | Methods of generating gene specific libraries |
| US8828688B2 (en) * | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
| EP2670894B1 (en) * | 2011-02-02 | 2017-11-29 | University Of Washington Through Its Center For Commercialization | Massively parallel continguity mapping |
| AU2013251701A1 (en) * | 2012-04-24 | 2014-10-30 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| US20150197787A1 (en) * | 2012-08-02 | 2015-07-16 | Qiagen Gmbh | Recombinase mediated targeted dna enrichment for next generation sequencing |
| CN105518151B (zh) * | 2013-03-15 | 2021-05-25 | 莱兰斯坦福初级大学评议会 | 循环核酸肿瘤标志物的鉴别和用途 |
| KR102122632B1 (ko) | 2013-08-05 | 2020-06-16 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| EP3039161B1 (en) * | 2013-08-30 | 2021-10-06 | Personalis, Inc. | Methods and systems for genomic analysis |
| EP3063301A4 (en) * | 2013-10-29 | 2017-07-19 | Longhorn Vaccines and Diagnostics, LLC | Next generation genomic sequencing methods |
| JP2020504709A (ja) * | 2016-11-18 | 2020-02-13 | ツイスト バイオサイエンス コーポレーション | 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 |
-
2017
- 2017-11-17 JP JP2019525959A patent/JP2020504709A/ja active Pending
- 2017-11-17 GB GB1908719.6A patent/GB2572877A/en not_active Withdrawn
- 2017-11-17 CN CN201780084031.1A patent/CN110382752A/zh active Pending
- 2017-11-17 US US15/816,995 patent/US20180142289A1/en not_active Abandoned
- 2017-11-17 IL IL314890A patent/IL314890A/en unknown
- 2017-11-17 AU AU2017363204A patent/AU2017363204B2/en not_active Ceased
- 2017-11-17 KR KR1020197017281A patent/KR102569164B1/ko active Active
- 2017-11-17 EP EP17872347.4A patent/EP3541973B1/en active Active
- 2017-11-17 WO PCT/US2017/062391 patent/WO2018094263A1/en not_active Ceased
- 2017-11-17 CA CA3044057A patent/CA3044057A1/en active Pending
- 2017-11-17 IL IL266681A patent/IL266681B2/en unknown
-
2021
- 2021-06-17 US US17/350,750 patent/US20210348220A1/en not_active Abandoned
-
2022
- 2022-10-28 JP JP2022173718A patent/JP2023017863A/ja active Pending
-
2023
- 2023-02-15 AU AU2023200850A patent/AU2023200850A1/en not_active Abandoned
-
2024
- 2024-10-31 JP JP2024192262A patent/JP2025028854A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017363204B2 (en) | 2022-12-08 |
| GB201908719D0 (en) | 2019-07-31 |
| JP2025028854A (ja) | 2025-03-05 |
| EP3541973A1 (en) | 2019-09-25 |
| WO2018094263A1 (en) | 2018-05-24 |
| IL266681B2 (en) | 2025-01-01 |
| IL266681A (en) | 2019-07-31 |
| CN110382752A (zh) | 2019-10-25 |
| GB2572877A (en) | 2019-10-16 |
| JP2020504709A (ja) | 2020-02-13 |
| CA3044057A1 (en) | 2018-05-24 |
| US20210348220A1 (en) | 2021-11-11 |
| JP2023017863A (ja) | 2023-02-07 |
| AU2017363204A1 (en) | 2019-07-04 |
| IL266681B1 (en) | 2024-09-01 |
| EP3541973A4 (en) | 2020-07-29 |
| KR20190093585A (ko) | 2019-08-09 |
| AU2023200850A1 (en) | 2023-03-16 |
| US20180142289A1 (en) | 2018-05-24 |
| EP3541973B1 (en) | 2024-03-27 |
| KR102569164B1 (ko) | 2023-08-21 |
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