JP2020504709A - 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 - Google Patents

制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 Download PDF

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JP2020504709A
JP2020504709A JP2019525959A JP2019525959A JP2020504709A JP 2020504709 A JP2020504709 A JP 2020504709A JP 2019525959 A JP2019525959 A JP 2019525959A JP 2019525959 A JP2019525959 A JP 2019525959A JP 2020504709 A JP2020504709 A JP 2020504709A
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polynucleotides
polynucleotide
library
percent
sequence
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JP2020504709A5 (OSRAM
Inventor
イブライム ゼイトン，ラムゼイ
イブライム ゼイトン，ラムゼイ
チェン，スーユアン
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ツイスト バイオサイエンス コーポレーション
ツイスト バイオサイエンス コーポレーション
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Publication of JP2020504709A publication Critical patent/JP2020504709A/ja
Publication of JP2020504709A5 publication Critical patent/JP2020504709A5/ja
Priority to JP2022173718A priority Critical patent/JP2023017863A/ja
Priority to JP2024192262A priority patent/JP2025028854A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019525959A 2016-11-18 2017-11-17 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成 Pending JP2020504709A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022173718A JP2023017863A (ja) 2016-11-18 2022-10-28 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成
JP2024192262A JP2025028854A (ja) 2016-11-18 2024-10-31 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662424302P 2016-11-18 2016-11-18
US62/424,302 2016-11-18
US201762548307P 2017-08-21 2017-08-21
US62/548,307 2017-08-21
US201762558666P 2017-09-14 2017-09-14
US62/558,666 2017-09-14
PCT/US2017/062391 WO2018094263A1 (en) 2016-11-18 2017-11-17 Polynucleotide libraries having controlled stoichiometry and synthesis thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022173718A Division JP2023017863A (ja) 2016-11-18 2022-10-28 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成

Publications (2)

Publication Number Publication Date
JP2020504709A true JP2020504709A (ja) 2020-02-13
JP2020504709A5 JP2020504709A5 (OSRAM) 2020-12-24

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Family Applications (3)

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JP2019525959A Pending JP2020504709A (ja) 2016-11-18 2017-11-17 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成
JP2022173718A Pending JP2023017863A (ja) 2016-11-18 2022-10-28 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成
JP2024192262A Pending JP2025028854A (ja) 2016-11-18 2024-10-31 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成

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JP2022173718A Pending JP2023017863A (ja) 2016-11-18 2022-10-28 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成
JP2024192262A Pending JP2025028854A (ja) 2016-11-18 2024-10-31 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成

Country Status (10)

Country Link
US (2) US20180142289A1 (OSRAM)
EP (1) EP3541973B1 (OSRAM)
JP (3) JP2020504709A (OSRAM)
KR (1) KR102569164B1 (OSRAM)
CN (1) CN110382752A (OSRAM)
AU (2) AU2017363204B2 (OSRAM)
CA (1) CA3044057A1 (OSRAM)
GB (1) GB2572877A (OSRAM)
IL (2) IL266681B2 (OSRAM)
WO (1) WO2018094263A1 (OSRAM)

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JP2023017863A (ja) * 2016-11-18 2023-02-07 ツイスト バイオサイエンス コーポレーション 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成
JP2023528003A (ja) * 2020-05-28 2023-07-03 イルミナ インコーポレイテッド 異なる特徴を有するポリヌクレオチドのコピーの比較

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US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
HK1258869A1 (zh) 2015-09-18 2019-11-22 Twist Bioscience Corporation 寡核酸变体文库及其合成
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
US9895673B2 (en) 2015-12-01 2018-02-20 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
ES2956757T3 (es) 2016-05-02 2023-12-27 Becton Dickinson Co Codificación con códigos de barras moleculares precisa
SG11201901563UA (en) 2016-08-22 2019-03-28 Twist Bioscience Corp De novo synthesized nucleic acid libraries
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
AU2017378492B2 (en) 2016-12-16 2022-06-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US11550939B2 (en) 2017-02-22 2023-01-10 Twist Bioscience Corporation Nucleic acid based data storage using enzymatic bioencryption
EP3595674A4 (en) 2017-03-15 2020-12-16 Twist Bioscience Corporation BANKS OF VARIANTS OF IMMUNOLOGICAL SYNAPSE AND THEIR SYNTHESIS
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
IL271205B2 (en) 2017-06-12 2025-02-01 Twist Bioscience Corp Methods for assembling continuous nucleic acids
GB2581620A (en) 2017-09-11 2020-08-26 Twist Bioscience Corp GPCR binding proteins and synthesis thereof
CA3079613A1 (en) 2017-10-20 2019-04-25 Twist Bioscience Corporation Heated nanowells for polynucleotide synthesis
GB2585506A (en) 2018-01-04 2021-01-13 Twist Bioscience Corp DNA-based digital information storage
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
EP3902816A4 (en) 2018-12-26 2022-09-14 Twist Bioscience Corporation HIGHLY ACCURATE POLYNUCLEOTIDE DE NOVO SYNTHESIS
JP2022521551A (ja) 2019-02-26 2022-04-08 ツイスト バイオサイエンス コーポレーション Ｇｌｐ１受容体の変異体核酸ライブラリ
AU2020227802A1 (en) 2019-02-26 2021-10-14 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
AU2020298294A1 (en) 2019-06-21 2022-02-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US12091777B2 (en) 2019-09-23 2024-09-17 Twist Bioscience Corporation Variant nucleic acid libraries for CRTH2
EP4034564A4 (en) 2019-09-23 2023-12-13 Twist Bioscience Corporation VARIANT NUCLEIC ACID LIBRARIES FOR SINGLE-DOMAIN ANTIBODIES
WO2021092244A1 (en) * 2019-11-06 2021-05-14 Adaptive Biotechnologies Corporation Synthetic strands for nucleic acid sequencing and related methods and systems
CN110853708B (zh) * 2019-11-13 2022-03-08 上海仁东医学检验所有限公司 用于hla分型的核酸捕获探针的设计方法
EP4142784A4 (en) 2020-04-27 2024-12-18 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CORONAVIRUS
EP4150110A4 (en) * 2020-05-11 2024-06-26 Personal Genome Diagnostics Inc. SELECTIVE CAPTURE OF TARGET DNA SEQUENCES
AU2021331088A1 (en) 2020-08-26 2023-05-04 Twist Bioscience Corporation Methods and compositions relating to glp1r variants
WO2022086866A1 (en) 2020-10-19 2022-04-28 Twist Bioscience Corporation Methods of synthesizing oligonucleotides using tethered nucleotides
WO2022159620A1 (en) 2021-01-21 2022-07-28 Twist Bioscience Corporation Methods and compositions relating to adenosine receptors
BE1029144B1 (fr) * 2021-02-25 2022-09-20 Oncodna Méthode de caracterisation d'une tumeur à l'aide d'un séquençage ciblé
US12258406B2 (en) 2021-03-24 2025-03-25 Twist Bioscience Corporation Antibodies that bind CD3 Epsilon
WO2022271884A2 (en) 2021-06-22 2022-12-29 Twist Bioscience Corporation Methods and compositions relating to covid antibody epitopes
WO2023091614A2 (en) 2021-11-18 2023-05-25 Twist Bioscience Corporation Dickkopf-1 variant antibodies and methods of use
US12325739B2 (en) 2022-01-03 2025-06-10 Twist Bioscience Corporation Bispecific SARS-CoV-2 antibodies and methods of use
CN116417071A (zh) * 2023-04-07 2023-07-11 祥符实验室 一种dna数据存储的选择性访问方法

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JP2023528003A (ja) * 2020-05-28 2023-07-03 イルミナ インコーポレイテッド 異なる特徴を有するポリヌクレオチドのコピーの比較

Also Published As

Publication number Publication date
AU2017363204B2 (en) 2022-12-08
IL266681B2 (en) 2025-01-01
US20180142289A1 (en) 2018-05-24
GB2572877A (en) 2019-10-16
US20210348220A1 (en) 2021-11-11
EP3541973B1 (en) 2024-03-27
WO2018094263A1 (en) 2018-05-24
AU2023200850A1 (en) 2023-03-16
KR102569164B1 (ko) 2023-08-21
CA3044057A1 (en) 2018-05-24
JP2023017863A (ja) 2023-02-07
IL314890A (en) 2024-10-01
KR20190093585A (ko) 2019-08-09
CN110382752A (zh) 2019-10-25
JP2025028854A (ja) 2025-03-05
IL266681B1 (en) 2024-09-01
EP3541973A4 (en) 2020-07-29
GB201908719D0 (en) 2019-07-31
EP3541973A1 (en) 2019-09-25
IL266681A (en) 2019-07-31
AU2017363204A1 (en) 2019-07-04

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