IL31390A - Nitrofuran derivatives,their preparation,and pharmaceutical and veterinary compositions containing them - Google Patents
Nitrofuran derivatives,their preparation,and pharmaceutical and veterinary compositions containing themInfo
- Publication number
- IL31390A IL31390A IL31390A IL3139069A IL31390A IL 31390 A IL31390 A IL 31390A IL 31390 A IL31390 A IL 31390A IL 3139069 A IL3139069 A IL 3139069A IL 31390 A IL31390 A IL 31390A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical
- carboxylic acid
- reaction mixture
- veterinary compositions
- radical
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 6
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 title description 5
- 229940027988 antiseptic and disinfectant nitrofuran derivative Drugs 0.000 title description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 15
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 10
- 229910017604 nitric acid Inorganic materials 0.000 claims description 10
- 239000011541 reaction mixture Substances 0.000 claims description 6
- 150000008064 anhydrides Chemical class 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- VYOBETUUXYCOLS-UHFFFAOYSA-N (2-formyl-5-nitro-2H-furan-5-yl) propanoate propanoic acid Chemical compound C(CC)(=O)O.C(CC)(=O)O.[N+](=O)([O-])C1(C=CC(O1)C=O)OC(CC)=O VYOBETUUXYCOLS-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 230000000802 nitrating effect Effects 0.000 description 2
- 238000006396 nitration reaction Methods 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/18—Esters of thiophosphoric acids with hydroxyaryl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI000768 | 1968-01-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL31390A0 IL31390A0 (en) | 1969-03-27 |
| IL31390A true IL31390A (en) | 1972-09-28 |
Family
ID=10994345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL31390A IL31390A (en) | 1968-01-09 | 1969-01-09 | Nitrofuran derivatives,their preparation,and pharmaceutical and veterinary compositions containing them |
Country Status (8)
| Country | Link |
|---|---|
| CA (1) | CA948645A (enrdf_load_stackoverflow) |
| DE (1) | DE1900711A1 (enrdf_load_stackoverflow) |
| DK (1) | DK123478B (enrdf_load_stackoverflow) |
| FR (1) | FR2000089A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1250992A (enrdf_load_stackoverflow) |
| IL (1) | IL31390A (enrdf_load_stackoverflow) |
| NL (1) | NL157800B (enrdf_load_stackoverflow) |
| SE (1) | SE357965B (enrdf_load_stackoverflow) |
-
1969
- 1969-01-03 SE SE00080/69A patent/SE357965B/xx unknown
- 1969-01-07 GB GB1250992D patent/GB1250992A/en not_active Expired
- 1969-01-08 DE DE19691900711 patent/DE1900711A1/de active Pending
- 1969-01-08 NL NL6900306.A patent/NL157800B/xx unknown
- 1969-01-09 DK DK11769AA patent/DK123478B/da unknown
- 1969-01-09 CA CA039,641A patent/CA948645A/en not_active Expired
- 1969-01-09 IL IL31390A patent/IL31390A/en unknown
- 1969-01-09 FR FR6900166A patent/FR2000089A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA948645A (en) | 1974-06-04 |
| IL31390A0 (en) | 1969-03-27 |
| DE1900711A1 (de) | 1969-07-31 |
| SE357965B (enrdf_load_stackoverflow) | 1973-07-16 |
| FR2000089A1 (enrdf_load_stackoverflow) | 1969-08-29 |
| DK123478B (da) | 1972-06-26 |
| GB1250992A (enrdf_load_stackoverflow) | 1971-10-27 |
| NL6900306A (enrdf_load_stackoverflow) | 1969-07-11 |
| NL157800B (nl) | 1978-09-15 |
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