IL312910A - Anti-galectin-9 antibodies and uses thereof - Google Patents

Anti-galectin-9 antibodies and uses thereof

Info

Publication number
IL312910A
IL312910A IL312910A IL31291024A IL312910A IL 312910 A IL312910 A IL 312910A IL 312910 A IL312910 A IL 312910A IL 31291024 A IL31291024 A IL 31291024A IL 312910 A IL312910 A IL 312910A
Authority
IL
Israel
Prior art keywords
seq
antibody
galectin
chain variable
cdr2
Prior art date
Application number
IL312910A
Other languages
English (en)
Hebrew (he)
Original Assignee
Univ New York
PureTech Health LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66246040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL312910(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ New York, PureTech Health LLC filed Critical Univ New York
Publication of IL312910A publication Critical patent/IL312910A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
IL312910A 2017-10-27 2018-10-29 Anti-galectin-9 antibodies and uses thereof IL312910A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762578111P 2017-10-27 2017-10-27
US201862665175P 2018-05-01 2018-05-01
US201862736317P 2018-09-25 2018-09-25
PCT/US2018/058028 WO2019084553A1 (en) 2017-10-27 2018-10-29 ANTI-GALECTIN-9 ANTIBODIES AND USES THEREOF

Publications (1)

Publication Number Publication Date
IL312910A true IL312910A (en) 2024-07-01

Family

ID=66246040

Family Applications (3)

Application Number Title Priority Date Filing Date
IL280648A IL280648B2 (en) 2017-10-27 2018-10-29 Anti-galectin-9 antibodies and uses thereof
IL312910A IL312910A (en) 2017-10-27 2018-10-29 Anti-galectin-9 antibodies and uses thereof
IL274152A IL274152B (en) 2017-10-27 2020-04-22 Anti-galectin-9 antibodies and their uses

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL280648A IL280648B2 (en) 2017-10-27 2018-10-29 Anti-galectin-9 antibodies and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL274152A IL274152B (en) 2017-10-27 2020-04-22 Anti-galectin-9 antibodies and their uses

Country Status (14)

Country Link
US (5) US10344091B2 (enrdf_load_stackoverflow)
EP (2) EP4597112A2 (enrdf_load_stackoverflow)
JP (5) JP6873445B2 (enrdf_load_stackoverflow)
KR (1) KR102162129B1 (enrdf_load_stackoverflow)
CN (2) CN111511765B (enrdf_load_stackoverflow)
AU (3) AU2018355588C1 (enrdf_load_stackoverflow)
CA (1) CA3080120C (enrdf_load_stackoverflow)
DK (1) DK3625263T3 (enrdf_load_stackoverflow)
ES (1) ES3032734T3 (enrdf_load_stackoverflow)
IL (3) IL280648B2 (enrdf_load_stackoverflow)
PT (1) PT3625263T (enrdf_load_stackoverflow)
SG (1) SG11202003652QA (enrdf_load_stackoverflow)
WO (1) WO2019084553A1 (enrdf_load_stackoverflow)
ZA (3) ZA202002246B (enrdf_load_stackoverflow)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL280648B2 (en) 2017-10-27 2024-10-01 Univ New York Anti-galectin-9 antibodies and uses thereof
JP7126615B2 (ja) * 2018-11-30 2022-08-26 海尓智家股▲フン▼有限公司 空冷式冷蔵庫
AU2020247993A1 (en) * 2019-03-25 2021-11-18 New York University Anti-Galectin-9 antibodies and uses thereof
WO2020223702A1 (en) * 2019-05-01 2020-11-05 New York University Anti-galectin-9 antibodies and uses thereof
EP3976102A4 (en) * 2019-05-31 2023-07-12 The Council of the Queensland Institute of Medical Research IMMUNE-INHIBITION ANTI-GAL9 BINDING MOLECULES
CA3142251A1 (en) * 2019-05-31 2020-12-03 The Council Of The Queensland Institute Of Medical Research Activating anti-gal9 binding molecules
EP3987011A1 (en) * 2019-06-24 2022-04-27 UPM-Kymmene Corporation Transplantable cell composition comprising eukaryotic cells in a nanofibrillar cellulose hydrogel, method for preparing thereof and use of nanofibrillar cellulose
WO2021007503A1 (en) * 2019-07-11 2021-01-14 Dana-Farber Cancer Institute, Inc. Targeting galectin-9 as a therapeutic strategy for t-cell exhaustion in t-cell acute lymphoblastic leukemia
AU2020319899A1 (en) * 2019-08-01 2022-02-24 New York University Combined cancer therapy of anti-galectin-9 antibodies and chemotherapeutics
US20230183336A1 (en) * 2019-08-14 2023-06-15 Modmab Therapeutics Inc. Antibodies that bind to lrp5 proteins and methods of use
MX2022008421A (es) * 2020-01-07 2022-09-23 Hifibio Hk Ltd Anticuerpo anti-galectina-9 y usos del mismo.
WO2022020745A1 (en) * 2020-07-23 2022-01-27 Emory University Galectin-9 specific binding agents for use in treating cancer
EP4192878A4 (en) * 2020-08-04 2025-04-16 Exelixis, Inc. Multi-specific binders and uses thereof
WO2022031680A1 (en) * 2020-08-04 2022-02-10 Exelixis, Inc. Cd47 binding agents and uses thereof
EP4192884A4 (en) * 2020-08-04 2025-04-09 Exelixis, Inc. PD-L1-BINDING AGENTS AND USES THEREOF
EP4232089A4 (en) * 2020-10-26 2024-09-04 PureTech LYT, Inc. ANTI-GALECTIN-9 ANTIBODIES AND USES THEREOF IN THE TREATMENT OF OCULAR MELANOMAS
WO2022109302A1 (en) * 2020-11-20 2022-05-27 New York University Anti-galectin-9 antibodies and therapeutic uses thereof
WO2022183112A2 (en) * 2021-02-26 2022-09-01 New York University Compositions and methods comprising antibodies that bind to covalent peptide conjugates
JP2024519449A (ja) * 2021-04-30 2024-05-14 ピュアテック・エル・ワイ・ティ・インコーポレイテッド がん治療における使用のための抗ガレクチン－９抗体と化学療法剤との併用
WO2022261337A2 (en) * 2021-06-11 2022-12-15 The Regents Of The University Of California Antibodies that stimulate nk cell-mediated cytotoxicity
EP4413048A2 (en) * 2021-10-06 2024-08-14 The University of Chicago Survivin targeting polypeptides for detection and treatment of cancer
WO2023245021A2 (en) * 2022-06-14 2023-12-21 Invenra Inc. Multispecific binding agents that target cd25 and/or ctla4 and uses thereof
CN119546330A (zh) * 2022-06-29 2025-02-28 纯技术Lyt股份有限公司 用抑制半乳糖凝集素-9的抗体治疗血液恶性肿瘤
US20240277122A1 (en) * 2023-02-16 2024-08-22 Dongguan Casekey Industry Co., Ltd Card fixation assembly for card holder and card holder
TW202506733A (zh) 2023-06-12 2025-02-16 美商安進公司 淋巴毒素β受體促效劑結合蛋白
WO2025014933A1 (en) * 2023-07-10 2025-01-16 Northwestern University Targeting tim-3 in mapk-driven glioma
WO2025085792A1 (en) * 2023-10-19 2025-04-24 Puretech Lyt, Inc. Treatment of hematological malignancies with antibodies inhibiting galectin-9
WO2025129249A1 (en) * 2023-12-22 2025-06-26 Commonwealth Scientific And Industrial Research Organisation Identifying sequence functionality

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP1892296A1 (en) 1988-09-02 2008-02-27 Dyax Corporation Generation and selection of recombinant varied binding proteins
WO1990007936A1 (en) 1989-01-23 1990-07-26 Chiron Corporation Recombinant therapies for infection and hyperproliferative disorders
ES2200016T3 (es) 1989-03-21 2004-03-01 Vical Incorporated Expresion de secuencias polinucleotidicas exogenas en un vertebrado.
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
WO1991002805A2 (en) 1989-08-18 1991-03-07 Viagene, Inc. Recombinant retroviruses delivering vector constructs to target cells
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ZA911974B (en) 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ　アンティボディー　テクノロジー　リミティド 特異的な結合ペアーの構成員の製造方法
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
DK1279731T3 (da) 1991-03-01 2007-09-24 Dyax Corp Fremgangsmåde til udvikling af bindende miniproteiner
ES2315612T3 (es) 1991-04-10 2009-04-01 The Scripps Research Institute Genotecas de receptores heterodimericos usando fagemidos.
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
JP3534749B2 (ja) 1991-08-20 2004-06-07 アメリカ合衆国 アデノウイルスが介在する胃腸管への遺伝子の輸送
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993010218A1 (en) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
GB9125623D0 (en) 1991-12-02 1992-01-29 Dynal As Cell modification
EP0552108B1 (en) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Energy transfer phase-modulation fluoro-immunoassay
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1993025234A1 (en) 1992-06-08 1993-12-23 The Regents Of The University Of California Methods and compositions for targeting specific tissue
EP0644946A4 (en) 1992-06-10 1997-03-12 Us Health VECTOR PARTICLES RESISTANT TO HUMAN SERUM INACTIVATION.
SE9201984D0 (sv) 1992-06-29 1992-06-29 Pharmacia Biosensor Ab Improvement in optical assays
GB2269175A (en) 1992-07-31 1994-02-02 Imperial College Retroviral vectors
CA2145641C (en) 1992-12-03 2008-05-27 Richard J. Gregory Pseudo-adenovirus vectors
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5759573A (en) 1993-04-22 1998-06-02 Depotech Corporation Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use
EP0705344B8 (en) 1993-06-24 2006-05-10 Advec Inc. Adenovirus vectors for gene therapy
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
DE69430369T2 (de) 1993-09-15 2002-10-17 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Rekombinanter alphavirus vektor
EP0797676B9 (en) 1993-10-25 2006-06-28 CANJI, Inc. Recombinant adenoviral vector and methods of use
KR100241300B1 (ko) 1993-11-16 2000-03-02 Sheldon A. Schaffer 활성물질의 조절된 방출성을 갖는 소포
EP0772689B1 (en) 1994-05-09 2007-12-19 Oxford Biomedica (UK) Limited Retroviral vectors having a reduced recombination rate
WO1996017072A2 (en) 1994-11-30 1996-06-06 Chiron Viagene, Inc. Recombinant alphavirus vectors
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
DE69739286D1 (de) 1996-05-06 2009-04-16 Oxford Biomedica Ltd Rekombinationsunfähige retrovirale vektoren
ATE332368T1 (de) 1997-01-21 2006-07-15 Gen Hospital Corp Selektion von proteinen mittels rns-protein fusionen
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
CA2364484A1 (en) 1999-03-09 2000-09-14 University Of Southern California Method of promoting myocyte proliferation and myocardial tissue repair
CA2427523A1 (en) 2000-11-01 2003-04-30 Galpharma Co., Ltd. Predicting agent for metastasis
CA2462113C (en) 2001-10-01 2013-01-29 Dyax Corp. Multi-chain eukaryotic display vectors and uses thereof
JP2004244411A (ja) * 2003-01-24 2004-09-02 Galpharma Co Ltd ガレクチン９含有医薬
WO2004064857A1 (ja) * 2003-01-24 2004-08-05 Galpharma Co., Ltd. ガレクチン９含有医薬
CA2542332C (en) 2003-10-16 2013-03-12 Stephen John Ralph Immunomodulating compositions and uses therefor
EP1838735A2 (en) 2004-12-31 2007-10-03 Genentech, Inc. Polypeptides that bind br3 and uses thereof
US20070237764A1 (en) 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
US8133488B2 (en) 2008-01-18 2012-03-13 Genentech, Inc. Methods and compositions for targeting polyubiquitin
ES2337224B1 (es) 2008-06-11 2011-02-17 Consejo Superior De Investigaciones Cientificas (Csic) (40%) Anticuerpo anti-dectin-1 humano, hibridoma productor de dicho anticuerpo y sus aplicaciones.
CN102165075A (zh) 2008-07-18 2011-08-24 奥洁克公司 用于检测和治疗结肠直肠癌的组合物
WO2011159877A2 (en) 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
JP6163429B2 (ja) 2010-11-10 2017-07-12 ジェネンテック， インコーポレイテッド 神経疾患免疫治療のための方法及び組成物
KR20130103587A (ko) 2010-12-09 2013-09-23 가르파마 컴퍼니 리미티드 갈렉틴 9를 분비하는 세포, 그 제조 방법 및 그 용도
WO2012177788A1 (en) 2011-06-20 2012-12-27 La Jolla Institute For Allergy And Immunology Modulators of 4-1bb and immune responses
WO2013056352A1 (en) * 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
WO2013116590A1 (en) 2012-02-01 2013-08-08 George Miller Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
WO2015035112A1 (en) 2013-09-05 2015-03-12 The Johns Hopkins University Cancer therapy via a combination of epigenetic modulation and immune modulation
EP3134439B1 (en) 2014-04-21 2018-12-26 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
FR3021970B1 (fr) * 2014-06-06 2018-01-26 Universite Sciences Technologies Lille Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs
SG11201700281SA (en) 2014-07-14 2017-02-27 Queensland Inst Med Res Galectin immunotherapy
MX386789B (es) 2014-09-16 2025-03-19 Innate Pharma Neutralización de vías inhibidoras en linfocitos.
US10640549B2 (en) * 2014-10-17 2020-05-05 University Of Virginia Patent Foundation Recombinant antibodies that recognize the C-terminal domains of Ebola virus nucleoprotein
CA2966040A1 (en) 2014-11-04 2016-05-12 Dana-Farber Cancer Institute, Inc. Anti-galectin antibody biomarkers predictive of anti-immune checkpoint and anti-angiogenesis responses
US20160209425A1 (en) 2015-01-16 2016-07-21 New York University Use of dectin-1 activators for treatment of liver disorders
WO2017044308A1 (en) 2015-09-10 2017-03-16 Albert Einstein College Of Medicine, Inc. Synthetic antibodies to bax and uses thereof
EP3463452A1 (en) 2016-05-24 2019-04-10 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
WO2018023113A1 (en) 2016-07-29 2018-02-01 New York University Treating solid tumor by targeting dectin-1 signaling
AU2017331739A1 (en) 2016-09-23 2019-03-07 Csl Limited Coagulation factor binding proteins and uses thereof
IL280648B2 (en) 2017-10-27 2024-10-01 Univ New York Anti-galectin-9 antibodies and uses thereof
WO2020014465A1 (en) 2018-07-11 2020-01-16 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
AU2020247993A1 (en) 2019-03-25 2021-11-18 New York University Anti-Galectin-9 antibodies and uses thereof
WO2020223702A1 (en) 2019-05-01 2020-11-05 New York University Anti-galectin-9 antibodies and uses thereof

Also Published As

Publication number Publication date
AU2018355588B2 (en) 2020-10-15
KR102162129B1 (ko) 2020-10-06
EP3625263A1 (en) 2020-03-25
ZA202303412B (en) 2024-09-25
WO2019084553A1 (en) 2019-05-02
JP7092317B2 (ja) 2022-06-28
AU2023285898A1 (en) 2024-01-18
JP2024133590A (ja) 2024-10-02
US11414492B2 (en) 2022-08-16
ZA202102905B (en) 2023-04-26
EP3625263B8 (en) 2025-05-28
NZ764590A (en) 2020-12-18
IL280648B2 (en) 2024-10-01
EP4597112A2 (en) 2025-08-06
US11629191B2 (en) 2023-04-18
AU2020294364A1 (en) 2021-02-18
US10450374B2 (en) 2019-10-22
CA3080120A1 (en) 2019-05-02
PT3625263T (pt) 2025-06-20
JP2021153585A (ja) 2021-10-07
DK3625263T3 (da) 2025-06-30
AU2020294364B2 (en) 2023-09-21
JP2021501120A (ja) 2021-01-14
ES3032734T3 (en) 2025-07-24
IL280648A (en) 2021-03-25
US20190127472A1 (en) 2019-05-02
SG11202003652QA (en) 2020-05-28
US20220332830A1 (en) 2022-10-20
CN111511765A (zh) 2020-08-07
IL280648B1 (en) 2024-06-01
AU2018355588C1 (en) 2023-04-27
CN111511765B (zh) 2022-05-27
ZA202002246B (en) 2025-04-30
CN115261392A (zh) 2022-11-01
KR102162129B9 (ko) 2023-02-08
EP3625263B1 (en) 2025-04-09
EP3625263A4 (en) 2021-05-05
JP7307443B2 (ja) 2023-07-12
AU2018355588A1 (en) 2020-06-11
US10344091B2 (en) 2019-07-09
KR20200064150A (ko) 2020-06-05
CA3080120C (en) 2023-11-21
JP7523084B2 (ja) 2024-07-26
US20190256604A1 (en) 2019-08-22
IL274152B (en) 2021-02-28
CN115261392B (zh) 2025-05-13
US20200010551A1 (en) 2020-01-09
JP2023116789A (ja) 2023-08-22
JP2022116325A (ja) 2022-08-09
JP6873445B2 (ja) 2021-05-19
IL274152A (en) 2020-06-30
US20220340666A1 (en) 2022-10-27

Similar Documents

Publication Publication Date Title
US11629191B2 (en) Anti-galectin-9 antibodies and uses thereof
US20220204629A1 (en) Anti-galectin-9 antibodies and uses thereof
US12084500B2 (en) Antibodies specific to delta 1 chain of T cell receptor
HK40082759A (en) Anti-galectin-9 antibodies and uses thereof
NZ764590B2 (en) Anti-galectin-9 antibodies and uses thereof
WO2024073522A2 (en) Antibodies binding to leukocyte immunoglobulin-like receptor subfamily b member 2 (lilrb2) and uses thereof