IL311564A - Microtubule-associated protein tau (MAPT) iRNA compositions and methods of using them - Google Patents

Microtubule-associated protein tau (MAPT) iRNA compositions and methods of using them

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Publication number
IL311564A
IL311564A IL311564A IL31156424A IL311564A IL 311564 A IL311564 A IL 311564A IL 311564 A IL311564 A IL 311564A IL 31156424 A IL31156424 A IL 31156424A IL 311564 A IL311564 A IL 311564A
Authority
IL
Israel
Prior art keywords
dsrna agent
nucleotide
nucleotides
strand
antisense strand
Prior art date
Application number
IL311564A
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English (en)
Hebrew (he)
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of IL311564A publication Critical patent/IL311564A/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N2320/10—Applications; Uses in screening processes
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
IL311564A 2021-09-24 2022-09-23 Microtubule-associated protein tau (MAPT) iRNA compositions and methods of using them IL311564A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163248119P 2021-09-24 2021-09-24
US202263321573P 2022-03-18 2022-03-18
US202263403327P 2022-09-02 2022-09-02
PCT/US2022/076979 WO2023049871A2 (en) 2021-09-24 2022-09-23 Microtubule associated protein tau (mapt) irna agent compositions and methods of use thereof

Publications (1)

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IL311564A true IL311564A (en) 2024-05-01

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IL311564A IL311564A (en) 2021-09-24 2022-09-23 Microtubule-associated protein tau (MAPT) iRNA compositions and methods of using them

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US (1) US12516322B2 (https=)
EP (1) EP4405484A4 (https=)
JP (1) JP2024536811A (https=)
KR (1) KR20240067943A (https=)
AU (1) AU2022348935A1 (https=)
CA (1) CA3233101A1 (https=)
CL (1) CL2024000858A1 (https=)
CO (1) CO2024003968A2 (https=)
IL (1) IL311564A (https=)
MX (1) MX2024003519A (https=)
TW (1) TW202328449A (https=)
WO (1) WO2023049871A2 (https=)

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EP4493691A2 (en) * 2022-03-16 2025-01-22 JANSSEN Pharmaceutica NV Mapt sirna and uses thereof
WO2024220930A2 (en) * 2023-04-20 2024-10-24 Adarx Pharmaceuticals, Inc. Mapt-modulating compositions and methods of use thereof
AU2024313057A1 (en) * 2023-06-22 2025-10-30 Denali Therapeutics Inc. Compositions and methods for modulating tau expression
TW202515584A (zh) * 2023-10-11 2025-04-16 大陸商上海舶望製藥有限公司 用於抑制微管相關蛋白ｔａｕ（ｍａｐｔ）表達的組合物和方法
WO2025136994A1 (en) * 2023-12-19 2025-06-26 Sirius Therapeutics, Inc. Modifications of polynucleic acid molecules and uses thereof
US12551569B2 (en) 2024-03-31 2026-02-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use
WO2026067655A1 (zh) * 2024-09-26 2026-04-02 大睿生物医药科技(上海)有限公司 调控TAU表达的dsRNA分子

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