IL30998A - Process for the production of proteolytic enzyme preparations - Google Patents
Process for the production of proteolytic enzyme preparationsInfo
- Publication number
- IL30998A IL30998A IL30998A IL3099868A IL30998A IL 30998 A IL30998 A IL 30998A IL 30998 A IL30998 A IL 30998A IL 3099868 A IL3099868 A IL 3099868A IL 30998 A IL30998 A IL 30998A
- Authority
- IL
- Israel
- Prior art keywords
- cultivation
- enzyme preparations
- enzyme
- proteolytic enzyme
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 13
- 108091005804 Peptidases Proteins 0.000 title claims description 10
- 229940079919 digestives enzyme preparation Drugs 0.000 title claims description 10
- 102000035195 Peptidases Human genes 0.000 title claims description 9
- 238000004519 manufacturing process Methods 0.000 title description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 235000015097 nutrients Nutrition 0.000 claims description 8
- 241000193375 Bacillus alcalophilus Species 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 description 17
- 108090000790 Enzymes Proteins 0.000 description 17
- 229940088598 enzyme Drugs 0.000 description 17
- 239000000203 mixture Substances 0.000 description 12
- 238000005406 washing Methods 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 230000002797 proteolythic effect Effects 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 5
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 239000005018 casein Substances 0.000 description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
- 235000021240 caseins Nutrition 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000005259 measurement Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 108010056230 butyloxycarbonyl-phenylalanyl-prolyl-arginine Proteins 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 238000004453 electron probe microanalysis Methods 0.000 description 2
- UFZOPKFMKMAWLU-UHFFFAOYSA-N ethoxy(methyl)phosphinic acid Chemical compound CCOP(C)(O)=O UFZOPKFMKMAWLU-UHFFFAOYSA-N 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000017550 sodium carbonate Nutrition 0.000 description 2
- 229940001593 sodium carbonate Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000004380 ashing Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000003861 general physiology Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 125000001477 organic nitrogen group Chemical group 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F3/00—Biological treatment of water, waste water, or sewage
- C02F3/34—Biological treatment of water, waste water, or sewage characterised by the microorganisms used
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F3/00—Biological treatment of water, waste water, or sewage
- C02F3/34—Biological treatment of water, waste water, or sewage characterised by the microorganisms used
- C02F3/342—Biological treatment of water, waste water, or sewage characterised by the microorganisms used characterised by the enzymes used
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Water Supply & Treatment (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Hydrology & Water Resources (AREA)
- Biodiversity & Conservation Biology (AREA)
- Environmental & Geological Engineering (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51307/67A GB1205403A (en) | 1967-11-10 | 1967-11-10 | Preparation of proteolytic enzyme preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL30998A0 IL30998A0 (en) | 1969-01-29 |
| IL30998A true IL30998A (en) | 1972-09-28 |
Family
ID=10459481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL30998A IL30998A (en) | 1967-11-10 | 1968-11-03 | Process for the production of proteolytic enzyme preparations |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3674643A (ro) |
| AT (1) | AT290444B (ro) |
| BE (1) | BE723649A (ro) |
| BR (1) | BR6803854D0 (ro) |
| CH (1) | CH523319A (ro) |
| DE (1) | DE1807185C3 (ro) |
| ES (1) | ES360055A1 (ro) |
| FR (1) | FR1599036A (ro) |
| GB (1) | GB1205403A (ro) |
| IL (1) | IL30998A (ro) |
| NL (1) | NL6815944A (ro) |
| RO (1) | RO71501A (ro) |
| SE (1) | SE372561B (ro) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2105445A5 (ro) * | 1970-09-07 | 1972-04-28 | Inst Francais Du Petrole | |
| BE789805A (nl) * | 1971-10-06 | 1973-04-06 | Gist Brocades Nv | Werkwijze voor de bereiding van een proteolytisch enzym |
| GB1519148A (en) * | 1974-11-19 | 1978-07-26 | Gist Brocades Nv | Compositions of matter |
| DE2608252C2 (de) * | 1976-02-28 | 1985-08-08 | H. Krantz Gmbh & Co, 5100 Aachen | Klimaleuchte |
| US4797362A (en) * | 1985-06-06 | 1989-01-10 | Lion Corporation | Alkaline proteases and microorganisms producing same |
| DK386586D0 (da) * | 1986-08-14 | 1986-08-14 | Novo Industri As | Protease, fremgangsmaade til fremstilling deraf og anvendelse deraf |
| AU620026B2 (en) | 1987-02-27 | 1992-02-13 | Genencor International, Inc. | Molecular cloning and expression of genes encoding proteolytic enzymes |
| US4865983A (en) * | 1987-12-04 | 1989-09-12 | W. R. Grace & Co.-Conn. | Cleaning compositions containing protease produced by vibrio and method of use |
| DE3834550A1 (de) * | 1988-10-11 | 1990-04-19 | Basf Ag | Proteolytisches enzym, seine herstellung und verwendung |
| US5227300A (en) * | 1989-03-16 | 1993-07-13 | Olin Corporation | Identification, characterization and method of production of a novel microbial lipase |
| US5063160A (en) * | 1989-03-16 | 1991-11-05 | Olin Corporation | Identification, characterization, and method of production of a novel microbial lipase |
| US5168060A (en) * | 1989-03-16 | 1992-12-01 | Olin Corporation | Identification, characterization, and method of production of a novel microbial lipase |
| DE4037530A1 (de) * | 1990-11-26 | 1992-05-27 | Henkel Kgaa | Faellungsverfahren fuer exocellulaere proteine |
| DK58391D0 (da) * | 1991-04-03 | 1991-04-03 | Novo Nordisk As | Hidtil ukendte proteaser |
| US5275945A (en) * | 1991-10-08 | 1994-01-04 | Vista Chemical Company | Alkaline proteases stable in heavy-duty detergent liquids |
| EP0571014B1 (en) * | 1992-05-18 | 2004-03-31 | Genencor International, Inc. | Bacteria producing alkaline proteases, and production of these alkaline proteases |
| WO1995005477A1 (en) * | 1993-08-12 | 1995-02-23 | University Of Maryland | Thermostable alkaline metalloprotease produced by a hyphomonas, and preparation thereof |
| US6855548B2 (en) * | 2000-02-08 | 2005-02-15 | F. Hoffman-La Roche Ag | Use of acid-stable proteases in animal feed |
| US6960462B2 (en) * | 2000-02-08 | 2005-11-01 | Dsm Ip Assets B.V | Use of acid-stable subtilisin proteases in animal feed |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2530210A (en) * | 1947-01-23 | 1950-11-14 | Rohm & Haas | Production of enzymes in submerged cultures of bacteria |
-
1967
- 1967-11-10 GB GB51307/67A patent/GB1205403A/en not_active Expired
-
1968
- 1968-10-03 RO RO6863445A patent/RO71501A/ro unknown
- 1968-10-31 SE SE6814789A patent/SE372561B/xx unknown
- 1968-11-01 US US772830A patent/US3674643A/en not_active Expired - Lifetime
- 1968-11-03 IL IL30998A patent/IL30998A/en unknown
- 1968-11-06 DE DE1807185A patent/DE1807185C3/de not_active Expired
- 1968-11-07 CH CH1661068A patent/CH523319A/de not_active IP Right Cessation
- 1968-11-08 BR BR203854/68A patent/BR6803854D0/pt unknown
- 1968-11-08 FR FR1599036D patent/FR1599036A/fr not_active Expired
- 1968-11-08 BE BE723649D patent/BE723649A/xx not_active IP Right Cessation
- 1968-11-08 NL NL6815944A patent/NL6815944A/xx unknown
- 1968-11-09 ES ES360055A patent/ES360055A1/es not_active Expired
- 1968-11-11 AT AT1097468A patent/AT290444B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES360055A1 (es) | 1970-06-16 |
| CH523319A (de) | 1972-05-31 |
| GB1205403A (en) | 1970-09-16 |
| DE1807185B2 (de) | 1979-02-08 |
| NL6815944A (ro) | 1969-05-13 |
| US3674643A (en) | 1972-07-04 |
| BR6803854D0 (pt) | 1973-02-13 |
| DE1807185A1 (de) | 1969-06-19 |
| IL30998A0 (en) | 1969-01-29 |
| FR1599036A (ro) | 1970-07-15 |
| SE372561B (ro) | 1974-12-23 |
| DE1807185C3 (de) | 1979-10-04 |
| BE723649A (ro) | 1969-05-08 |
| RO71501A (ro) | 1982-02-26 |
| AT290444B (de) | 1971-06-11 |
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