IL309539A - Ezh2 inhibitors for treating lymphoma - Google Patents

Ezh2 inhibitors for treating lymphoma

Info

Publication number
IL309539A
IL309539A IL309539A IL30953923A IL309539A IL 309539 A IL309539 A IL 309539A IL 309539 A IL309539 A IL 309539A IL 30953923 A IL30953923 A IL 30953923A IL 309539 A IL309539 A IL 309539A
Authority
IL
Israel
Prior art keywords
lymphoma
ezh2
nhl
subject
compound
Prior art date
Application number
IL309539A
Other languages
English (en)
Hebrew (he)
Original Assignee
Epizyme Inc
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc, Eisai R&D Man Co Ltd filed Critical Epizyme Inc
Publication of IL309539A publication Critical patent/IL309539A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL309539A 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma IL309539A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462013522P 2014-06-17 2014-06-17
US201462036265P 2014-08-12 2014-08-12
PCT/US2015/036310 WO2015195848A1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma

Publications (1)

Publication Number Publication Date
IL309539A true IL309539A (en) 2024-02-01

Family

ID=54936086

Family Applications (3)

Application Number Title Priority Date Filing Date
IL309539A IL309539A (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma
IL285201A IL285201B2 (en) 2014-06-17 2015-06-17 EZH2 inhibitors for the treatment of lymphoma
IL249438A IL249438A0 (en) 2014-06-17 2016-12-07 ezh2 inhibitors for the treatment of lymphoma

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL285201A IL285201B2 (en) 2014-06-17 2015-06-17 EZH2 inhibitors for the treatment of lymphoma
IL249438A IL249438A0 (en) 2014-06-17 2016-12-07 ezh2 inhibitors for the treatment of lymphoma

Country Status (21)

Country Link
US (5) US10166238B2 (OSRAM)
EP (2) EP4252851A3 (OSRAM)
JP (1) JP6779793B2 (OSRAM)
KR (2) KR102497728B1 (OSRAM)
CN (2) CN113289022A (OSRAM)
AU (3) AU2015277139A1 (OSRAM)
BR (1) BR112016029492A2 (OSRAM)
CA (1) CA2952074C (OSRAM)
DK (1) DK3157527T3 (OSRAM)
EA (1) EA038337B1 (OSRAM)
ES (1) ES2948442T3 (OSRAM)
FI (1) FI3157527T3 (OSRAM)
HU (1) HUE062158T2 (OSRAM)
IL (3) IL309539A (OSRAM)
LT (1) LT3157527T (OSRAM)
MX (2) MX2021007651A (OSRAM)
PL (1) PL3157527T3 (OSRAM)
PT (1) PT3157527T (OSRAM)
SG (2) SG10201811128RA (OSRAM)
SI (1) SI3157527T1 (OSRAM)
WO (1) WO2015195848A1 (OSRAM)

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LT3157527T (lt) 2014-06-17 2023-07-25 Epizyme, Inc. Ezh2 inhibitoriai, skirti limfomos gydymui
IL289947B2 (en) * 2014-10-16 2024-06-01 Epizyme Inc Method for treating cancer
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AR102767A1 (es) 2014-12-05 2017-03-22 Lilly Co Eli Inhibidores de ezh2
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WO2016201328A1 (en) * 2015-06-10 2016-12-15 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
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WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
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Also Published As

Publication number Publication date
EP3157527A4 (en) 2018-05-23
JP2017518334A (ja) 2017-07-06
ES2948442T3 (es) 2023-09-12
WO2015195848A8 (en) 2016-07-07
US10166238B2 (en) 2019-01-01
MX2016016744A (es) 2017-11-30
SG11201610273VA (en) 2017-01-27
US20170216300A1 (en) 2017-08-03
US20200323866A1 (en) 2020-10-15
WO2015195848A1 (en) 2015-12-23
EP4252851A2 (en) 2023-10-04
EP3157527A1 (en) 2017-04-26
IL249438A0 (en) 2017-02-28
CA2952074A1 (en) 2015-12-23
SI3157527T1 (sl) 2023-09-29
AU2015277139A1 (en) 2016-12-22
DK3157527T3 (da) 2023-07-03
NZ727108A (en) 2023-09-29
AU2020244382A1 (en) 2020-10-29
CA2952074C (en) 2022-08-30
CN113289022A (zh) 2021-08-24
EA201692285A1 (ru) 2017-06-30
EA038337B1 (ru) 2021-08-11
IL285201B1 (en) 2024-01-01
SG10201811128RA (en) 2019-01-30
AU2020244382B2 (en) 2022-08-04
EA201692285A8 (ru) 2018-01-31
US20200022987A1 (en) 2020-01-23
US20240058348A1 (en) 2024-02-22
IL285201B2 (en) 2024-05-01
CN106999498B (zh) 2021-06-08
AU2022263523A1 (en) 2022-12-08
FI3157527T3 (fi) 2023-07-25
EP3157527B1 (en) 2023-05-24
PT3157527T (pt) 2023-06-30
HUE062158T2 (hu) 2023-10-28
KR20230031963A (ko) 2023-03-07
JP6779793B2 (ja) 2020-11-04
KR102497728B1 (ko) 2023-02-09
BR112016029492A2 (pt) 2017-10-17
US11642347B2 (en) 2023-05-09
IL285201A (en) 2021-08-31
PL3157527T3 (pl) 2023-08-07
EP4252851A3 (en) 2023-11-22
US20190175604A1 (en) 2019-06-13
KR20170052558A (ko) 2017-05-12
LT3157527T (lt) 2023-07-25
MX2021007651A (es) 2021-08-11
MX383866B (es) 2025-03-14
CN106999498A (zh) 2017-08-01

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