IL305078A - Crystalline solids of the MEK inhibitor N-((R)-3,2-dihydroxypropoxy)-4,3-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and their uses - Google Patents
Crystalline solids of the MEK inhibitor N-((R)-3,2-dihydroxypropoxy)-4,3-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and their usesInfo
- Publication number
- IL305078A IL305078A IL305078A IL30507823A IL305078A IL 305078 A IL305078 A IL 305078A IL 305078 A IL305078 A IL 305078A IL 30507823 A IL30507823 A IL 30507823A IL 305078 A IL305078 A IL 305078A
- Authority
- IL
- Israel
- Prior art keywords
- crystalline form
- dihydroxypropoxy
- difluoro
- fluoro
- iodo
- Prior art date
Links
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Organic Chemistry (AREA)
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| PCT/US2021/018381 WO2022177557A1 (en) | 2021-02-17 | 2021-02-17 | Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and uses thereof |
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| NZ546011A (en) | 2003-10-21 | 2009-09-25 | Warner Lambert Co | Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
| WO2006134469A1 (en) | 2005-06-14 | 2006-12-21 | Warner-Lambert Company Llc | Methods of preparing mek inhibitor |
| US11066358B1 (en) * | 2021-02-17 | 2021-07-20 | Warner-Lambert Company Llc | Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
| US11084780B1 (en) * | 2021-02-17 | 2021-08-10 | Springworks Therapeutics, Inc. | Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
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2021
- 2021-02-17 JP JP2023549993A patent/JP2024509759A/ja active Pending
- 2021-02-17 KR KR1020237031522A patent/KR20230147139A/ko unknown
- 2021-02-17 AU AU2021428512A patent/AU2021428512A1/en active Pending
- 2021-02-17 WO PCT/US2021/018381 patent/WO2022177557A1/en active Application Filing
- 2021-02-17 CN CN202180095459.2A patent/CN117083264A/zh active Pending
- 2021-02-17 CA CA3207513A patent/CA3207513A1/en active Pending
- 2021-02-17 IL IL305078A patent/IL305078A/en unknown
- 2021-02-17 EP EP21710829.9A patent/EP4294526A1/en active Pending
-
2022
- 2022-02-17 TW TW111105779A patent/TW202302526A/zh unknown
- 2022-02-17 AR ARP220100336A patent/AR124911A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR124911A1 (es) | 2023-05-17 |
| JP2024509759A (ja) | 2024-03-05 |
| TW202302526A (zh) | 2023-01-16 |
| WO2022177557A1 (en) | 2022-08-25 |
| CN117083264A (zh) | 2023-11-17 |
| CA3207513A1 (en) | 2022-08-25 |
| EP4294526A1 (en) | 2023-12-27 |
| AU2021428512A1 (en) | 2023-09-21 |
| KR20230147139A (ko) | 2023-10-20 |
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