IL303257A - Selective p2x3 modulators - Google Patents
Selective p2x3 modulatorsInfo
- Publication number
- IL303257A IL303257A IL303257A IL30325723A IL303257A IL 303257 A IL303257 A IL 303257A IL 303257 A IL303257 A IL 303257A IL 30325723 A IL30325723 A IL 30325723A IL 303257 A IL303257 A IL 303257A
- Authority
- IL
- Israel
- Prior art keywords
- selective
- antagonist
- receptor antagonism
- patient
- compound
- Prior art date
Links
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Veterinary Medicine (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Amplifiers (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
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| IL282087B2 (en) * | 2018-10-10 | 2025-11-01 | Bellus Health Cough Inc | 4-(imidazo[1,2-a]pyridin-3-yl)-benzamide derivatives for treating pruritus |
| DK3880678T3 (da) | 2018-11-13 | 2025-06-10 | Glaxosmithkline Intellectual Property No 3 Ltd | Krystallinske former af p2x3-modulator methyl(s)-2-((2-(2,6-difluoro-4-(methylcarbamoyl )phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholin-4-carboxylat |
| KR102797127B1 (ko) * | 2018-12-29 | 2025-04-21 | 우한 크리에이터나 사이언스 앤드 테크놀로지 컴퍼니, 리미티드 | 헤테로고리계 화합물, 중간체, 이의 제조 방법 및 용도 |
| CA3131312A1 (en) | 2019-02-25 | 2020-09-03 | Bellus Health Cough Inc. | Treatment with p2x3 modulators |
| CN112409331B (zh) * | 2019-08-21 | 2024-02-20 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| BR112022015818A2 (pt) | 2020-02-14 | 2022-10-25 | Bellus Health Cough Inc | Preparação de um antagonista de p2x3 |
| JP2023513373A (ja) * | 2020-02-14 | 2023-03-30 | べルス・ヘルス・コフ・インコーポレーテッド | Ｐ２ｘ３修飾薬 |
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| CN113754654A (zh) * | 2020-06-05 | 2021-12-07 | 武汉人福创新药物研发中心有限公司 | 咪唑并吡啶类化合物及其用途 |
| CN114085220B (zh) * | 2020-06-22 | 2023-06-16 | 上海海雁医药科技有限公司 | 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途 |
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| US20240408131A1 (en) * | 2020-07-06 | 2024-12-12 | Sensory Cloud, Inc. | Isotonic or hypertonic salt-based compositions |
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| CN113912601B (zh) * | 2020-07-10 | 2023-06-06 | 上海拓界生物医药科技有限公司 | 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途 |
| WO2022033567A1 (zh) * | 2020-08-13 | 2022-02-17 | 上海拓界生物医药科技有限公司 | 苯并咪唑类衍生物、其制备方法及医药用途 |
| WO2022161462A1 (zh) * | 2021-01-29 | 2022-08-04 | 上海海雁医药科技有限公司 | 吗啉衍生物及其药物组合物和用途 |
| WO2022258059A1 (zh) * | 2021-06-10 | 2022-12-15 | 武汉朗来科技发展有限公司 | 一种药物组合物、制剂及其制备方法和应用 |
| WO2023020156A1 (zh) * | 2021-08-20 | 2023-02-23 | 苏州璞正医药有限公司 | 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途 |
| WO2024194352A1 (en) | 2023-03-23 | 2024-09-26 | Glaxosmithkline Intellectual Property (No.3) Limited | Deuterated p2x3 modulators |
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| ES2442797T3 (es) * | 2009-11-18 | 2014-02-13 | Neomed Institute | Compuestos de benzoimidazol y sus utilizaciones |
| WO2011116392A2 (en) * | 2010-03-19 | 2011-09-22 | University Of Miami | Use of p2x purinergic receptor agonists to enhance insulin secretion in pancreatic beta cells |
| KR102120513B1 (ko) | 2013-01-31 | 2020-06-08 | 네오메드 인스티튜트 | 이미다조피리딘 화합물 및 이의 용도 |
| PE20160431A1 (es) * | 2013-08-23 | 2016-06-02 | Afferent Pharmaceuticals Inc | Moduladores del receptor p2x3 y p2x2/3 de diaminopiridina para el tratamiento de la tos aguda, sub-aguda o cronica |
| CU24411B1 (es) * | 2014-12-09 | 2019-05-03 | Bayer Ag | Compuesto derivado de benzamida sustituida con 1,3-tiazol-2-ilo útil para el tratamiento de trastornos neurogénicos |
| CA2998742C (en) * | 2015-09-29 | 2023-08-29 | Anthony P. FORD | Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough |
| US9907795B2 (en) * | 2016-01-08 | 2018-03-06 | Nerre Therapeutics Limited | Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents |
| CN109996546B (zh) * | 2016-09-30 | 2023-06-27 | 阿沙纳生物科学公司 | P2x3和/或p2x2/3化合物及方法 |
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- 2018-09-14 CN CN201880073147.XA patent/CN111601601A/zh active Pending
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| US20210069201A1 (en) | 2021-03-11 |
| JP7242681B2 (ja) | 2023-03-20 |
| IL273348B2 (en) | 2023-11-01 |
| KR102713354B1 (ko) | 2024-10-02 |
| SG11202002460QA (en) | 2020-04-29 |
| EP3684368B1 (en) | 2024-01-03 |
| AU2018342751A1 (en) | 2020-04-23 |
| EP4331669A3 (en) | 2024-05-01 |
| US20230248736A1 (en) | 2023-08-10 |
| US10111883B1 (en) | 2018-10-30 |
| EP3684368A4 (en) | 2021-05-26 |
| EP4331669A2 (en) | 2024-03-06 |
| CN111601601A (zh) | 2020-08-28 |
| KR20200092938A (ko) | 2020-08-04 |
| IL273348B1 (en) | 2023-07-01 |
| US20210322432A1 (en) | 2021-10-21 |
| EP3684368A2 (en) | 2020-07-29 |
| WO2019064079A2 (en) | 2019-04-04 |
| IL273348A (en) | 2020-05-31 |
| JP2020534355A (ja) | 2020-11-26 |
| MX2020002968A (es) | 2020-08-17 |
| EP3684368B8 (en) | 2024-02-14 |
| US20200230148A1 (en) | 2020-07-23 |
| AU2018342751B2 (en) | 2023-06-15 |
| CA3076150C (en) | 2024-01-02 |
| WO2019064079A3 (en) | 2019-05-16 |
| CA3076150A1 (en) | 2019-04-04 |
| US20220160724A1 (en) | 2022-05-26 |
| ES2969868T3 (es) | 2024-05-23 |
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