AU2018342751B2 - Selective P2X3 modulators - Google Patents

Selective P2X3 modulators Download PDF

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Publication number
AU2018342751B2
AU2018342751B2 AU2018342751A AU2018342751A AU2018342751B2 AU 2018342751 B2 AU2018342751 B2 AU 2018342751B2 AU 2018342751 A AU2018342751 A AU 2018342751A AU 2018342751 A AU2018342751 A AU 2018342751A AU 2018342751 B2 AU2018342751 B2 AU 2018342751B2
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AU
Australia
Prior art keywords
selective
antagonist
alkyl
receptor antagonism
compound
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Active
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AU2018342751A
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English (en)
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AU2018342751A1 (en
Inventor
Roberto Bellini
Susan E. Browne
Nathalie Chauret
Denis Garceau
Antonios Matzouranis
Kemal Payza
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Glaxosmithkline Intellectual Property No 3 Ltd
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Glaxosmithkline Intellectual Property No 3 Ltd
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Publication of AU2018342751A1 publication Critical patent/AU2018342751A1/en
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Assigned to BELLUS HEALTH COUGH INC. reassignment BELLUS HEALTH COUGH INC. Request for Assignment Assignors: BELLUS HEALTH COUGH INC., NEOMED INSTITUTE
Assigned to GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED reassignment GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED Request for Assignment Assignors: BELLUS HEALTH COUGH INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Amplifiers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
AU2018342751A 2017-09-18 2018-09-14 Selective P2X3 modulators Active AU2018342751B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762560077P 2017-09-18 2017-09-18
US62/560,077 2017-09-18
US15/936,316 US10111883B1 (en) 2017-09-18 2018-03-26 Selective P2X3 modulators
US15/936,316 2018-03-26
PCT/IB2018/001513 WO2019064079A2 (en) 2017-09-18 2018-09-14 SELECTIVE MODULATORS OF P2X3

Publications (2)

Publication Number Publication Date
AU2018342751A1 AU2018342751A1 (en) 2020-04-23
AU2018342751B2 true AU2018342751B2 (en) 2023-06-15

Family

ID=63894683

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018342751A Active AU2018342751B2 (en) 2017-09-18 2018-09-14 Selective P2X3 modulators

Country Status (12)

Country Link
US (6) US10111883B1 (enExample)
EP (2) EP3684368B8 (enExample)
JP (1) JP7242681B2 (enExample)
KR (1) KR102713354B1 (enExample)
CN (1) CN111601601A (enExample)
AU (1) AU2018342751B2 (enExample)
CA (1) CA3076150C (enExample)
ES (1) ES2969868T3 (enExample)
IL (2) IL273348B2 (enExample)
MX (1) MX2020002968A (enExample)
SG (1) SG11202002460QA (enExample)
WO (1) WO2019064079A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102613204B1 (ko) * 2018-10-05 2023-12-12 시오노기 앤드 컴파니, 리미티드 만성 해수 치료용 의약
WO2020074962A1 (en) * 2018-10-10 2020-04-16 Bellus Health Cough Inc. Treatment of pruritus with p2x3 antagonists
HUE071480T2 (hu) * 2018-11-13 2025-08-28 Glaxosmithkline Intellectual Property No 3 A P2X3-modulátor metil (S)-2-((2-(2,6-difluoro-4-(metil-karbamoil)fenil)-7-metilimidazo[1,2-a] piridin-3-il)metil)morfolin-4-karboxilát kristályos formái
AU2019416589B2 (en) * 2018-12-29 2023-04-06 Wuhan Ll Science And Technology Development Co., Ltd. Heterocyclic compound intermediate, preparation method therefor and application thereof
EP3930722A4 (en) * 2019-02-25 2022-12-28 Bellus Health Cough Inc. TREATMENT WITH P2X3 MODULATORS
CN112409331B (zh) * 2019-08-21 2024-02-20 上海翰森生物医药科技有限公司 杂环类衍生物抑制剂、其制备方法和应用
IL295393A (en) * 2020-02-14 2022-10-01 Bellus Health Cough Inc P2x3 modulators
BR112022021789A2 (pt) 2020-04-27 2023-03-07 Twist Bioscience Corp Bibliotecas de ácido nucléico variantes para coronavírus
CN113754654A (zh) * 2020-06-05 2021-12-07 武汉人福创新药物研发中心有限公司 咪唑并吡啶类化合物及其用途
CN114085220B (zh) * 2020-06-22 2023-06-16 上海海雁医药科技有限公司 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途
WO2022001820A1 (zh) * 2020-06-29 2022-01-06 武汉朗来科技发展有限公司 杂环类化合物的晶型及其制备方法和应用
US20240408131A1 (en) * 2020-07-06 2024-12-12 Sensory Cloud, Inc. Isotonic or hypertonic salt-based compositions
US20230218661A1 (en) * 2022-01-10 2023-07-13 Sensory Cloud, Inc. Isotonic or hypertonic salt-based compositions, treatments, devices, and articles for delivery of same to larynx
CN113912601B (zh) * 2020-07-10 2023-06-06 上海拓界生物医药科技有限公司 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途
BR112023001924A2 (pt) * 2020-08-13 2023-03-07 Tuojie Biotech Shanghai Co Ltd Derivados de benzimidazol, método de preparo para os mesmos e uso médico dos mesmos
CN116635389A (zh) * 2021-01-29 2023-08-22 上海海雁医药科技有限公司 吗啉衍生物及其药物组合物和用途
WO2022258059A1 (zh) * 2021-06-10 2022-12-15 武汉朗来科技发展有限公司 一种药物组合物、制剂及其制备方法和应用
CN115043836B (zh) * 2021-08-20 2023-07-18 苏州璞正医药有限公司 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途
CN120917022A (zh) 2023-03-23 2025-11-07 葛兰素史密斯克莱知识产权(第3号)有限公司 氘代p2x3调节剂

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2777746A1 (en) * 2009-11-18 2011-05-26 Astrazeneca Ab Benzoimidazole compounds and uses thereof
CA2898665A1 (en) * 2013-01-31 2014-08-07 Neomed Institute Imidazopyridine compounds and their use as p2x purinoreceptor modulators
CA2921395A1 (en) * 2013-08-23 2015-02-26 Afferent Pharmaceuticals Inc. Diaminopyrimidine p2x3 and p2x 2/3 receptor modulators for treatment of acute, sub-acute or chronic cough
CA2998742A1 (en) * 2015-09-29 2017-04-06 Anthony P. FORD Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough
WO2018064135A1 (en) * 2016-09-30 2018-04-05 Asana Biosciences, Llc P2x3 and/or p2x2/3 compounds and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522324A (ja) * 2010-03-19 2013-06-13 ユニバーシティー オブ マイアミ 膵臓β細胞におけるインスリン分泌を高めるためのＰ２Ｘプリン受容体アゴニストの使用
DK3587417T3 (da) * 2014-12-09 2022-03-28 Bayer Ag 1,3-thiazol-2-yl-substituerede benzamider
US9907795B2 (en) * 2016-01-08 2018-03-06 Nerre Therapeutics Limited Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2777746A1 (en) * 2009-11-18 2011-05-26 Astrazeneca Ab Benzoimidazole compounds and uses thereof
CA2898665A1 (en) * 2013-01-31 2014-08-07 Neomed Institute Imidazopyridine compounds and their use as p2x purinoreceptor modulators
CA2921395A1 (en) * 2013-08-23 2015-02-26 Afferent Pharmaceuticals Inc. Diaminopyrimidine p2x3 and p2x 2/3 receptor modulators for treatment of acute, sub-acute or chronic cough
CA2998742A1 (en) * 2015-09-29 2017-04-06 Anthony P. FORD Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough
WO2018064135A1 (en) * 2016-09-30 2018-04-05 Asana Biosciences, Llc P2x3 and/or p2x2/3 compounds and methods

Also Published As

Publication number Publication date
EP4331669A3 (en) 2024-05-01
WO2019064079A2 (en) 2019-04-04
MX2020002968A (es) 2020-08-17
WO2019064079A3 (en) 2019-05-16
EP3684368B8 (en) 2024-02-14
CN111601601A (zh) 2020-08-28
ES2969868T3 (es) 2024-05-23
IL273348B2 (en) 2023-11-01
EP3684368A2 (en) 2020-07-29
SG11202002460QA (en) 2020-04-29
EP3684368A4 (en) 2021-05-26
EP3684368B1 (en) 2024-01-03
US20230248736A1 (en) 2023-08-10
IL273348B1 (en) 2023-07-01
US20220160724A1 (en) 2022-05-26
IL273348A (en) 2020-05-31
JP2020534355A (ja) 2020-11-26
CA3076150A1 (en) 2019-04-04
JP7242681B2 (ja) 2023-03-20
KR102713354B1 (ko) 2024-10-02
EP4331669A2 (en) 2024-03-06
US20200230148A1 (en) 2020-07-23
IL303257A (en) 2023-07-01
US10111883B1 (en) 2018-10-30
AU2018342751A1 (en) 2020-04-23
CA3076150C (en) 2024-01-02
US20210322432A1 (en) 2021-10-21
US20210069201A1 (en) 2021-03-11
KR20200092938A (ko) 2020-08-04

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PC1 Assignment before grant (sect. 113)

Owner name: BELLUS HEALTH COUGH INC.

Free format text: FORMER APPLICANT(S): BELLUS HEALTH COUGH INC.; NEOMED INSTITUTE

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED

Free format text: FORMER OWNER(S): BELLUS HEALTH COUGH INC.