IL303115A - Detection of hematological disorders using cell-free DNA in blood - Google Patents

Detection of hematological disorders using cell-free DNA in blood

Info

Publication number
IL303115A
IL303115A IL303115A IL30311523A IL303115A IL 303115 A IL303115 A IL 303115A IL 303115 A IL303115 A IL 303115A IL 30311523 A IL30311523 A IL 30311523A IL 303115 A IL303115 A IL 303115A
Authority
IL
Israel
Prior art keywords
dna
methylation
cell
plasma
blood
Prior art date
Application number
IL303115A
Other languages
English (en)
Hebrew (he)
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of IL303115A publication Critical patent/IL303115A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL303115A 2016-05-30 2017-05-30 Detection of hematological disorders using cell-free DNA in blood IL303115A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662343050P 2016-05-30 2016-05-30
PCT/CN2017/086509 WO2017206888A1 (en) 2016-05-30 2017-05-30 Detecting hematological disorders using cell-free dna in blood

Publications (1)

Publication Number Publication Date
IL303115A true IL303115A (en) 2023-07-01

Family

ID=60479040

Family Applications (2)

Application Number Title Priority Date Filing Date
IL262953A IL262953B2 (en) 2016-05-30 2017-05-30 Detection of hematological disorders using cell-free DNA in blood
IL303115A IL303115A (en) 2016-05-30 2017-05-30 Detection of hematological disorders using cell-free DNA in blood

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL262953A IL262953B2 (en) 2016-05-30 2017-05-30 Detection of hematological disorders using cell-free DNA in blood

Country Status (12)

Country Link
US (3) US10781490B2 (ko)
EP (3) EP4324937A3 (ko)
JP (3) JP6987393B2 (ko)
KR (3) KR102605504B1 (ko)
CN (2) CN115161390A (ko)
AU (2) AU2017274038B2 (ko)
CA (1) CA3025708A1 (ko)
DK (2) DK3885447T3 (ko)
IL (2) IL262953B2 (ko)
SG (1) SG11201810544WA (ko)
TW (2) TW202426661A (ko)
WO (1) WO2017206888A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3889272A1 (en) 2014-07-18 2021-10-06 The Chinese University of Hong Kong Methylation pattern analysis of tissues in dna mixture
CA3025708A1 (en) 2016-05-30 2017-12-07 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free dna in blood
AU2017369018B2 (en) 2016-11-30 2021-02-25 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine and other samples
DK3574108T3 (da) 2017-01-25 2024-09-16 The Chinese Univ Of Hong Kong Diagnostisk anvendelse ved brug af nukleinsyrefragment
KR20200035427A (ko) 2017-07-26 2020-04-03 더 차이니즈 유니버시티 오브 홍콩 세포-무함유 바이러스 핵산을 사용하는 암 스크리닝의 증강
WO2019173283A1 (en) 2018-03-05 2019-09-12 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
TW202102687A (zh) 2019-03-25 2021-01-16 香港中文大學 確定循環核酸之線性及環狀形式
CN110361531B (zh) * 2019-08-02 2023-04-11 天津医科大学总医院 一种检测微粒促凝活性的实验方法
CN115175985A (zh) * 2019-12-20 2022-10-11 威廉马歇莱思大学 从未经处理的生物样本中提取单链dna和rna并测序的方法
CN111518876B (zh) * 2020-05-11 2023-01-13 润方(北京)生物医药研究院有限公司 一种牛血红蛋白制品中牛源基因组dna定量检测方法及其应用
KR102517894B1 (ko) * 2021-02-23 2023-04-04 연세대학교 산학협력단 당뇨발에 의한 하지 절단 수술의 치료 반응성을 예측하는 방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE312946T1 (de) 2002-03-05 2005-12-15 Epigenomics Ag Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten
US20090176655A1 (en) * 2007-11-16 2009-07-09 Oncomethylome Sciences Sa Methylation detection
US20110028333A1 (en) * 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
NZ601079A (en) 2010-01-26 2014-08-29 Nipd Genetics Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
WO2011130751A1 (en) 2010-04-16 2011-10-20 Chronix Biomedical Breast cancer associated circulating nucleic acid biomarkers
MX370249B (es) 2010-11-30 2019-12-06 Univ Hong Kong Chinese Deteccion de aberraciones genéticas o moleculares asociadas con el cáncer.
WO2012103031A2 (en) 2011-01-25 2012-08-02 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US20140178348A1 (en) 2011-05-25 2014-06-26 The Regents Of The University Of California Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
ES2693672T3 (es) 2011-09-26 2018-12-13 Qiagen Gmbh Método rápido para aislar ácidos nucleicos extracelulares
ES2729554T3 (es) 2011-10-21 2019-11-04 Chronix Biomedical Biomarcadores de ácidos nucleicos en circulación asociados al cáncer colorrectal
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
NZ706269A (en) * 2012-09-20 2016-08-26 Univ Hong Kong Chinese Non-invasive determination of methylome of fetus or tumor from plasma
EP3099822A4 (en) 2014-01-30 2017-08-30 The Regents of the University of California Methylation haplotyping for non-invasive diagnosis (monod)
LT4026917T (lt) 2014-04-14 2024-03-12 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Ląstelių ar audinio žūties nustatymo arba iš audinio ar ląstelės gautos dnr kilmės nustatymo dnr metilinimo analizės būdu metodas ir rinkinys
EP3140421B8 (en) 2014-05-09 2020-05-06 Eurofins LifeCodexx GmbH Detection of dna that originates from a specific cell-type and related methods
EP3889272A1 (en) 2014-07-18 2021-10-06 The Chinese University of Hong Kong Methylation pattern analysis of tissues in dna mixture
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
CA3025708A1 (en) 2016-05-30 2017-12-07 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free dna in blood

Also Published As

Publication number Publication date
SG11201810544WA (en) 2018-12-28
KR20190013878A (ko) 2019-02-11
US20200385811A1 (en) 2020-12-10
TW201800754A (zh) 2018-01-01
JP7537758B2 (ja) 2024-08-21
CN115161390A (zh) 2022-10-11
KR102605504B1 (ko) 2023-11-22
JP2024054311A (ja) 2024-04-16
CN109196120B (zh) 2022-08-02
AU2023203305A1 (en) 2023-06-22
TW202426661A (zh) 2024-07-01
KR102482616B1 (ko) 2022-12-28
US20240229103A1 (en) 2024-07-11
EP3885447B1 (en) 2024-01-10
KR20230164209A (ko) 2023-12-01
JP2022024127A (ja) 2022-02-08
AU2017274038B2 (en) 2023-03-16
IL262953B2 (en) 2023-11-01
EP3464637A4 (en) 2019-12-11
TWI838330B (zh) 2024-04-11
CA3025708A1 (en) 2017-12-07
US10781490B2 (en) 2020-09-22
EP3464637B1 (en) 2021-06-23
EP4324937A3 (en) 2024-05-15
EP4324937A2 (en) 2024-02-21
US11873527B2 (en) 2024-01-16
EP3464637A1 (en) 2019-04-10
IL262953B1 (en) 2023-07-01
IL262953A (en) 2018-12-31
WO2017206888A1 (en) 2017-12-07
DK3464637T3 (da) 2021-07-26
CN109196120A (zh) 2019-01-11
DK3885447T3 (da) 2024-04-15
JP6987393B2 (ja) 2021-12-22
KR20230003666A (ko) 2023-01-06
US20170349948A1 (en) 2017-12-07
EP3885447A1 (en) 2021-09-29
AU2017274038A1 (en) 2018-12-06
JP2019524056A (ja) 2019-09-05

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