IL303115A - Detection of hematological disorders using cell-free DNA in blood - Google Patents
Detection of hematological disorders using cell-free DNA in bloodInfo
- Publication number
- IL303115A IL303115A IL303115A IL30311523A IL303115A IL 303115 A IL303115 A IL 303115A IL 303115 A IL303115 A IL 303115A IL 30311523 A IL30311523 A IL 30311523A IL 303115 A IL303115 A IL 303115A
- Authority
- IL
- Israel
- Prior art keywords
- dna
- methylation
- cell
- plasma
- blood
- Prior art date
Links
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- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
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| PCT/CN2017/086509 WO2017206888A1 (en) | 2016-05-30 | 2017-05-30 | Detecting hematological disorders using cell-free dna in blood |
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| EP3889272A1 (en) | 2014-07-18 | 2021-10-06 | The Chinese University of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| US10781490B2 (en) | 2016-05-30 | 2020-09-22 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free DNA in blood |
| JP2020503003A (ja) | 2016-11-30 | 2020-01-30 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 尿および他のサンプルにおける無細胞ｄｎａの分析 |
| SG11201906397UA (en) | 2017-01-25 | 2019-08-27 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| ES2959360T3 (es) | 2017-07-26 | 2024-02-23 | Univ Hong Kong Chinese | Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares |
| US12089930B2 (en) | 2018-03-05 | 2024-09-17 | Marquette University | Method and apparatus for non-invasive hemoglobin level prediction |
| EP3947717A4 (en) | 2019-03-25 | 2022-12-28 | The Chinese University Of Hong Kong | DETERMINATION OF LINEAR AND ROUND SHAPES OF CIRCULATION NUCLEIC ACIDS |
| CN110361531B (zh) * | 2019-08-02 | 2023-04-11 | 天津医科大学总医院 | 一种检测微粒促凝活性的实验方法 |
| WO2021127526A1 (en) * | 2019-12-20 | 2021-06-24 | William Marsh Rice University | Methods for extracting and sequencing single-stranded dna and rna from non-treated biospecimens |
| CN111518876B (zh) * | 2020-05-11 | 2023-01-13 | 润方（北京）生物医药研究院有限公司 | 一种牛血红蛋白制品中牛源基因组dna定量检测方法及其应用 |
| KR102517894B1 (ko) * | 2021-02-23 | 2023-04-04 | 연세대학교 산학협력단 | 당뇨발에 의한 하지 절단 수술의 치료 반응성을 예측하는 방법 |
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| US20110028333A1 (en) * | 2009-05-01 | 2011-02-03 | Brown University | Diagnosing, prognosing, and early detection of cancers by dna methylation profiling |
| DK2529032T3 (en) | 2010-01-26 | 2017-05-01 | Nipd Genetics Ltd | METHODS AND COMPOSITIONS FOR NON-INVASIVE PRE-NATIONAL DIAGNOSTICATION OF Fetal ANEUPLOIDITIES |
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| AU2011335891B2 (en) | 2010-11-30 | 2015-03-26 | The Chinese University Of Hong Kong | Detection of genetic or molecular aberrations associated with cancer |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US20140178348A1 (en) | 2011-05-25 | 2014-06-26 | The Regents Of The University Of California | Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| CN113388605A (zh) | 2011-09-26 | 2021-09-14 | 凯杰有限公司 | 用于分离细胞外核酸的快速方法 |
| CA2852098C (en) | 2011-10-21 | 2023-05-02 | Chronix Biomedical | Colorectal cancer associated circulating nucleic acid biomarkers |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| PT2898100T (pt) * | 2012-09-20 | 2018-02-26 | Univ Hong Kong Chinese | Determinação não invasiva de um metiloma de feto ou tumor a partir de plasma |
| EP3099822A4 (en) | 2014-01-30 | 2017-08-30 | The Regents of the University of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| HRP20240189T1 (hr) | 2014-04-14 | 2024-04-26 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. | Postupak i komplet za utvrđivanje odumiranja stanica ili tkiva ili tkivnog ili staničnog podrijetla dnk-a analizom metilacije dnk-a |
| MA39951A (fr) | 2014-05-09 | 2017-03-15 | Lifecodexx Ag | Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées |
| EP3889272A1 (en) | 2014-07-18 | 2021-10-06 | The Chinese University of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US10781490B2 (en) | 2016-05-30 | 2020-09-22 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free DNA in blood |
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