IL294535A - Zinc finger protein transcription factors for repressing tau expression - Google Patents
Zinc finger protein transcription factors for repressing tau expressionInfo
- Publication number
- IL294535A IL294535A IL294535A IL29453522A IL294535A IL 294535 A IL294535 A IL 294535A IL 294535 A IL294535 A IL 294535A IL 29453522 A IL29453522 A IL 29453522A IL 294535 A IL294535 A IL 294535A
- Authority
- IL
- Israel
- Prior art keywords
- zfp
- fusion protein
- dna
- cell
- domain
- Prior art date
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| KR20210070344A (ko) | 2018-10-02 | 2021-06-14 | 상가모 테라퓨틱스, 인코포레이티드 | 타우 단백질의 조정을 위한 방법 및 조성물 |
| KR20220071248A (ko) * | 2019-10-02 | 2022-05-31 | 상가모 테라퓨틱스, 인코포레이티드 | 알파-시누클레인 발현을 억제시키기 위한 아연 핑거 단백질 전사 인자 |
| WO2025193848A1 (en) * | 2024-03-13 | 2025-09-18 | Sangamo Therapeutics, Inc. | Delivery of tau repressors using the blood-brain barrier penetrant capsid |
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| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| ATE524545T1 (de) | 1994-08-20 | 2011-09-15 | Gendaq Ltd | Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| DE69942334D1 (de) | 1998-03-02 | 2010-06-17 | Massachusetts Inst Technology | Poly-zinkfinger-proteine mit verbesserten linkern |
| WO2001053480A1 (en) | 2000-01-24 | 2001-07-26 | Sangamo Biosciences, Inc. | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| US9394531B2 (en) | 2008-05-28 | 2016-07-19 | Sangamo Biosciences, Inc. | Compositions for linking DNA-binding domains and cleavage domains |
| PT2566972T (pt) | 2010-05-03 | 2020-03-02 | Sangamo Biosciences Inc | Composições para a ligação de módulos de dedo de zinco |
| AU2014312295C1 (en) | 2013-08-28 | 2020-08-13 | Sangamo Therapeutics, Inc. | Compositions for linking DNA-binding domains and cleavage domains |
| CN106459894B (zh) | 2014-03-18 | 2020-02-18 | 桑格摩生物科学股份有限公司 | 用于调控锌指蛋白表达的方法和组合物 |
| WO2017011556A1 (en) * | 2015-07-13 | 2017-01-19 | The General Hospital Corporation | Rare phosphorylated high molecular weight (hmw) tau species that are involved in neuronal uptake and propagation and applications thereof |
| EP3411056A4 (en) | 2016-02-02 | 2019-10-02 | Sangamo Therapeutics, Inc. | COMPOUNDS FOR NETWORKING DNA BINDING DOMAINS AND SPLITTING DOMAINS |
| SG10201913948PA (en) | 2016-08-24 | 2020-03-30 | Sangamo Therapeutics Inc | Engineered target specific nucleases |
| CN110214184B (zh) * | 2016-12-01 | 2024-07-02 | 桑格摩生物治疗股份有限公司 | τ蛋白调节剂以及用于其递送的方法和组合物 |
| CA3115158A1 (en) | 2018-10-02 | 2020-04-09 | Sangamo Therapeutics, Inc. | Engineered genetic modulators |
| KR20210070344A (ko) | 2018-10-02 | 2021-06-14 | 상가모 테라퓨틱스, 인코포레이티드 | 타우 단백질의 조정을 위한 방법 및 조성물 |
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