MX2022008953A - Factores de transcripcion de proteina de dedos de zinc para reprimir la expresion de tau. - Google Patents
Factores de transcripcion de proteina de dedos de zinc para reprimir la expresion de tau.Info
- Publication number
- MX2022008953A MX2022008953A MX2022008953A MX2022008953A MX2022008953A MX 2022008953 A MX2022008953 A MX 2022008953A MX 2022008953 A MX2022008953 A MX 2022008953A MX 2022008953 A MX2022008953 A MX 2022008953A MX 2022008953 A MX2022008953 A MX 2022008953A
- Authority
- MX
- Mexico
- Prior art keywords
- zinc finger
- repressing
- transcription factors
- finger protein
- protein transcription
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente descripción proporciona proteínas de fusión de dedos de zinc que inhiben la expresión de tau en el sistema nervioso, y métodos para usar las proteínas para tratar enfermedades neurodegenerativas tal como enfermedad de Alzheimer, demencia frontotemporal, y otras tauopatías.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062964501P | 2020-01-22 | 2020-01-22 | |
PCT/US2021/014780 WO2021151012A1 (en) | 2020-01-22 | 2021-01-22 | Zinc finger protein transcription factors for repressing tau expression |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022008953A true MX2022008953A (es) | 2022-08-15 |
Family
ID=74661487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022008953A MX2022008953A (es) | 2020-01-22 | 2021-01-22 | Factores de transcripcion de proteina de dedos de zinc para reprimir la expresion de tau. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20230242602A1 (es) |
EP (1) | EP4093754A1 (es) |
JP (1) | JP2023511908A (es) |
KR (1) | KR20220131273A (es) |
CN (1) | CN115210251A (es) |
AR (1) | AR121118A1 (es) |
AU (1) | AU2021209699A1 (es) |
BR (1) | BR112022014160A2 (es) |
CA (1) | CA3168805A1 (es) |
IL (1) | IL294535A (es) |
MX (1) | MX2022008953A (es) |
TW (1) | TW202134288A (es) |
UY (1) | UY39036A (es) |
WO (1) | WO2021151012A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL266862B2 (en) | 2016-12-01 | 2024-01-01 | Sangamo Therapeutics Inc | Tau modulators and methods and preparations for their administration |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2181548C (en) | 1994-01-18 | 2009-11-03 | Carlos F. Barbas, Iii | Zinc finger protein derivatives and methods therefor |
US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
USRE45795E1 (en) | 1994-08-20 | 2015-11-10 | Gendaq, Ltd. | Binding proteins for recognition of DNA |
GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
AU746454B2 (en) | 1998-03-02 | 2002-05-02 | Massachusetts Institute Of Technology | Poly zinc finger proteins with improved linkers |
CA2398155C (en) | 2000-01-24 | 2011-07-19 | Sangamo Biosciences, Inc. | Methods and compositions for linking binding domains in nucleic acid binding proteins |
US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
JP2011521643A (ja) | 2008-05-28 | 2011-07-28 | サンガモ バイオサイエンシーズ, インコーポレイテッド | Dna結合ドメインおよび切断ドメインを連結するための組成物 |
WO2011139349A1 (en) | 2010-05-03 | 2011-11-10 | Sangamo Biosciences, Inc. | Compositions for linking zinc finger modules |
CA2920899C (en) | 2013-08-28 | 2023-02-28 | Sangamo Biosciences, Inc. | Compositions for linking dna-binding domains and cleavage domains |
US9624498B2 (en) | 2014-03-18 | 2017-04-18 | Sangamo Biosciences, Inc. | Methods and compositions for regulation of zinc finger protein expression |
WO2017011556A1 (en) * | 2015-07-13 | 2017-01-19 | The General Hospital Corporation | Rare phosphorylated high molecular weight (hmw) tau species that are involved in neuronal uptake and propagation and applications thereof |
CN109069568B (zh) | 2016-02-02 | 2023-07-07 | 桑格摩生物治疗股份有限公司 | 用于连接dna结合结构域和切割结构域的组合物 |
AU2017315414B2 (en) | 2016-08-24 | 2024-02-15 | Sangamo Therapeutics, Inc. | Engineered target specific nucleases |
IL266862B2 (en) * | 2016-12-01 | 2024-01-01 | Sangamo Therapeutics Inc | Tau modulators and methods and preparations for their administration |
WO2020072684A1 (en) | 2018-10-02 | 2020-04-09 | Sangamo Therapeutics, Inc. | Engineered genetic modulators |
WO2020072677A1 (en) | 2018-10-02 | 2020-04-09 | Sangamo Therapeutics, Inc. | Methods and compositions for modulation of tau proteins |
-
2021
- 2021-01-22 CN CN202180010601.9A patent/CN115210251A/zh active Pending
- 2021-01-22 IL IL294535A patent/IL294535A/en unknown
- 2021-01-22 JP JP2022544353A patent/JP2023511908A/ja active Pending
- 2021-01-22 MX MX2022008953A patent/MX2022008953A/es unknown
- 2021-01-22 KR KR1020227028167A patent/KR20220131273A/ko active Search and Examination
- 2021-01-22 WO PCT/US2021/014780 patent/WO2021151012A1/en unknown
- 2021-01-22 UY UY0001039036A patent/UY39036A/es unknown
- 2021-01-22 US US17/791,395 patent/US20230242602A1/en active Pending
- 2021-01-22 EP EP21706102.7A patent/EP4093754A1/en active Pending
- 2021-01-22 CA CA3168805A patent/CA3168805A1/en active Pending
- 2021-01-22 AU AU2021209699A patent/AU2021209699A1/en active Pending
- 2021-01-22 BR BR112022014160A patent/BR112022014160A2/pt not_active Application Discontinuation
- 2021-01-22 AR ARP210100163A patent/AR121118A1/es unknown
- 2021-01-22 TW TW110102602A patent/TW202134288A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AR121118A1 (es) | 2022-04-20 |
IL294535A (en) | 2022-09-01 |
WO2021151012A1 (en) | 2021-07-29 |
JP2023511908A (ja) | 2023-03-23 |
UY39036A (es) | 2021-08-31 |
BR112022014160A2 (pt) | 2022-09-13 |
EP4093754A1 (en) | 2022-11-30 |
CA3168805A1 (en) | 2021-07-29 |
CN115210251A (zh) | 2022-10-18 |
AU2021209699A1 (en) | 2022-07-21 |
US20230242602A1 (en) | 2023-08-03 |
TW202134288A (zh) | 2021-09-16 |
KR20220131273A (ko) | 2022-09-27 |
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