IL290562A - RNA-guided nucleases and active fragments and their variants and methods for use - Google Patents
RNA-guided nucleases and active fragments and their variants and methods for useInfo
- Publication number
- IL290562A IL290562A IL290562A IL29056222A IL290562A IL 290562 A IL290562 A IL 290562A IL 290562 A IL290562 A IL 290562A IL 29056222 A IL29056222 A IL 29056222A IL 290562 A IL290562 A IL 290562A
- Authority
- IL
- Israel
- Prior art keywords
- rna
- variants
- methods
- active fragments
- guided nucleases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962885483P | 2019-08-12 | 2019-08-12 | |
| US201962901875P | 2019-09-18 | 2019-09-18 | |
| US202063030088P | 2020-05-26 | 2020-05-26 | |
| PCT/US2020/045759 WO2021030344A1 (en) | 2019-08-12 | 2020-08-11 | Rna-guided nucleases and active fragments and variants thereof and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL290562A true IL290562A (en) | 2022-04-01 |
Family
ID=72243198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL290562A IL290562A (en) | 2019-08-12 | 2022-02-13 | RNA-guided nucleases and active fragments and their variants and methods for use |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12680096B2 (enExample) |
| EP (1) | EP4013864A1 (enExample) |
| JP (2) | JP7640527B2 (enExample) |
| KR (1) | KR20220062289A (enExample) |
| CN (2) | CN118813654A (enExample) |
| AU (1) | AU2020329912A1 (enExample) |
| BR (1) | BR112022002695A2 (enExample) |
| CA (1) | CA3147783A1 (enExample) |
| IL (1) | IL290562A (enExample) |
| MX (1) | MX2022001849A (enExample) |
| TW (1) | TW202120688A (enExample) |
| WO (1) | WO2021030344A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN113631704A (zh) * | 2018-12-27 | 2021-11-09 | 生命编辑制药股份有限公司 | 可用于基因编辑的多肽及使用方法 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| JP2023516226A (ja) | 2020-04-24 | 2023-04-18 | ライフエディット セラピューティクス，インコーポレイティド | Ｒｎａ誘導型ヌクレアーゼとその活性な断片およびバリアント、ならびに利用の方法 |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN116194581A (zh) | 2020-07-01 | 2023-05-30 | 艾勒维生技公司 | 使用环状rna进行细胞重编程的组合物和方法 |
| JP7890972B2 (ja) | 2020-07-15 | 2026-07-15 | ライフ エディット セラピューティクス，インコーポレイティド | ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法 |
| EP4211235A2 (en) | 2020-09-11 | 2023-07-19 | Lifeedit Therapeutics, Inc. | Dna modifying enzymes and active fragments and variants thereof and methods of use |
| CA3173950A1 (en) * | 2021-03-22 | 2022-09-22 | Tyson D. BOWEN | Dna modifyng enzymes and active fragments and variants thereof and methods of use |
| US20250011740A1 (en) * | 2021-04-22 | 2025-01-09 | Emendobio Inc. | Novel omni 117, 140, 150-158, 160-165, 167-177, 180-188, 191-198, 200, 201, 203, 205-209, 211-217, 219, 220, 222, 223, 226, 227, 229, 231-236, 238-245, 247, 250, 254, 256, 257, 260 and 262 crispr nucleases |
| WO2024077267A1 (en) * | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
| IL320573A (en) | 2022-11-04 | 2025-07-01 | Life Edit Therapeutics Inc | Developed adenine deaminases and RNA-guided nuclease fusion proteins with internal insertion sites and methods of use |
| WO2024127370A1 (en) * | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target trac gene and methods of use |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| WO2025174908A1 (en) * | 2024-02-12 | 2025-08-21 | Life Edit Therapeutics, Inc. | Novel rna-guided nucleases and proteins for polymerase editing |
| TW202617985A (zh) | 2024-06-25 | 2026-05-01 | 美商生命編輯治療學公司 | 新穎反轉錄酶及其用途 |
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| EA201990815A1 (ru) | 2016-11-14 | 2019-09-30 | Институте Оф Генетисс Анд Девелопментал Биологй. Чинесе Асадемй Оф Ссиенсес | Способ редактирования основания у растений |
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| WO2018154418A1 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
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| BR112019023377A2 (pt) | 2017-05-11 | 2020-06-16 | Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences | Criação de um gene resistente a herbicida e uso do mesmo |
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| CN113631704A (zh) | 2018-12-27 | 2021-11-09 | 生命编辑制药股份有限公司 | 可用于基因编辑的多肽及使用方法 |
| US20220145274A1 (en) | 2019-03-12 | 2022-05-12 | Crispr Therapeutics Ag | Novel high fidelity rna-programmable endonuclease systems and uses thereof |
| US12173290B2 (en) | 2019-06-28 | 2024-12-24 | Crispr Therapeutics Ag | Materials and methods for controlling gene editing |
-
2020
- 2020-08-11 CN CN202411155276.7A patent/CN118813654A/zh active Pending
- 2020-08-11 BR BR112022002695A patent/BR112022002695A2/pt unknown
- 2020-08-11 CN CN202080068763.3A patent/CN114641568B/zh active Active
- 2020-08-11 JP JP2022509175A patent/JP7640527B2/ja active Active
- 2020-08-11 TW TW109127218A patent/TW202120688A/zh unknown
- 2020-08-11 WO PCT/US2020/045759 patent/WO2021030344A1/en not_active Ceased
- 2020-08-11 EP EP20761938.8A patent/EP4013864A1/en active Pending
- 2020-08-11 MX MX2022001849A patent/MX2022001849A/es unknown
- 2020-08-11 US US17/634,723 patent/US12680096B2/en active Active
- 2020-08-11 CA CA3147783A patent/CA3147783A1/en active Pending
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| Publication number | Publication date |
|---|---|
| KR20220062289A (ko) | 2022-05-16 |
| BR112022002695A2 (pt) | 2022-08-23 |
| JP7640527B2 (ja) | 2025-03-05 |
| AU2020329912A1 (en) | 2022-03-24 |
| CA3147783A1 (en) | 2021-02-18 |
| EP4013864A1 (en) | 2022-06-22 |
| CN114641568A (zh) | 2022-06-17 |
| CN118813654A (zh) | 2024-10-22 |
| MX2022001849A (es) | 2022-03-11 |
| US12680096B2 (en) | 2026-07-14 |
| TW202120688A (zh) | 2021-06-01 |
| WO2021030344A1 (en) | 2021-02-18 |
| JP2022545385A (ja) | 2022-10-27 |
| US20220364074A1 (en) | 2022-11-17 |
| JP2025086912A (ja) | 2025-06-09 |
| CN114641568B (zh) | 2024-09-06 |
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