IL288851B2 - Heteroaromatic inhibitors of astacin proteinases - Google Patents

Heteroaromatic inhibitors of astacin proteinases

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Publication number
IL288851B2
IL288851B2 IL288851A IL28885121A IL288851B2 IL 288851 B2 IL288851 B2 IL 288851B2 IL 288851 A IL288851 A IL 288851A IL 28885121 A IL28885121 A IL 28885121A IL 288851 B2 IL288851 B2 IL 288851B2
Authority
IL
Israel
Prior art keywords
alkyl
methyl
group
independently selected
carboxy
Prior art date
Application number
IL288851A
Other languages
English (en)
Hebrew (he)
Other versions
IL288851B1 (en
IL288851A (en
Original Assignee
Vivoryon Therapeutics N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivoryon Therapeutics N V filed Critical Vivoryon Therapeutics N V
Publication of IL288851A publication Critical patent/IL288851A/en
Publication of IL288851B1 publication Critical patent/IL288851B1/en
Publication of IL288851B2 publication Critical patent/IL288851B2/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624103A (en) * 1968-05-21 1971-11-30 Abc Ist Biolog Chem Spa 3-indoleacetohydroxamic acids
US4146721A (en) * 1969-09-12 1979-03-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrazol-4-acetic acid compounds
WO2006114263A1 (en) * 2005-04-25 2006-11-02 Novartis Ag Imidazo [1, 2-a] pyridine derivatives useful as peptide deformylase (pdf) inhibitors
WO2017182433A1 (en) * 2016-04-18 2017-10-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Novel inhibitors of meprin alpha and beta

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021448A (en) * 1975-10-21 1977-05-03 Sterling Drug Inc. 2-Substituted-indole-1-lower-alkanecarboxamides
KR100432928B1 (ko) * 2001-04-26 2004-05-28 주식회사 코오롱 신규한 하이드록스아믹산 유도체, 신규한 그의 중간체화합물 및 그들의 제조방법
US20090005344A1 (en) 2004-11-01 2009-01-01 Nkuada, Llc Compounds and Methods of Use Thereof
AU2008252628A1 (en) 2007-05-18 2008-11-27 Inhibox Ltd. Bicyclosulfonyl acid (BCSA) compounds and their use as therapeutic agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624103A (en) * 1968-05-21 1971-11-30 Abc Ist Biolog Chem Spa 3-indoleacetohydroxamic acids
US4146721A (en) * 1969-09-12 1979-03-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrazol-4-acetic acid compounds
WO2006114263A1 (en) * 2005-04-25 2006-11-02 Novartis Ag Imidazo [1, 2-a] pyridine derivatives useful as peptide deformylase (pdf) inhibitors
WO2017182433A1 (en) * 2016-04-18 2017-10-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Novel inhibitors of meprin alpha and beta

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. BOULAROT ET. AL.,, DISCOVERY AND REFINEMENT OF A NEW STRUCTURAL CLASS OF POTENT PEPTIDE DEFORMYLASE INHIBITORS., 15 December 2006 (2006-12-15) *
E. ADIGUZEL ET. AL.,, SYNTHESIS AND CHARACTERIZATION OF TWO NEW HYDROXAMIDC ACID DERIVATIVES AND THEIR METAL COMPLEXES. AN INVESTIGATION ON THE KETO/ENOL E/Z AND HYDROXAMATE/HYDROXIMATE FORMS., 19 July 2016 (2016-07-19) *

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JP7773377B2 (ja) 2025-11-19
CN114585608A (zh) 2022-06-03
KR102930913B1 (ko) 2026-02-27
EP3750878A1 (en) 2020-12-16
MX2021015324A (es) 2022-04-06
MX2025005324A (es) 2025-06-02
ZA202109419B (en) 2022-08-31
BR112021024327A2 (pt) 2022-01-11
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CA3300715A1 (en) 2026-03-02
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US20250388544A1 (en) 2025-12-25
CA3142992A1 (en) 2020-12-17
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IL288851B1 (en) 2025-10-01
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US20230122243A1 (en) 2023-04-20
IL288851A (en) 2022-02-01
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AU2020291114A1 (en) 2021-12-23
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