BR112021024327A2 - Inibidores heteroaromáticos de astacina proteinases - Google Patents

Inibidores heteroaromáticos de astacina proteinases

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Publication number
BR112021024327A2
BR112021024327A2 BR112021024327A BR112021024327A BR112021024327A2 BR 112021024327 A2 BR112021024327 A2 BR 112021024327A2 BR 112021024327 A BR112021024327 A BR 112021024327A BR 112021024327 A BR112021024327 A BR 112021024327A BR 112021024327 A2 BR112021024327 A2 BR 112021024327A2
Authority
BR
Brazil
Prior art keywords
astacin
heteroaromatic
proteinase inhibitors
proteinase
inhibitors
Prior art date
Application number
BR112021024327A
Other languages
English (en)
Inventor
Dagmar Schlenzig
Daniel Ramsbeck
Holger Cynis
Kathrin Tan
Mirko Buchholz
Stephan Schilling
Original Assignee
Vivoryon Therapeutics N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivoryon Therapeutics N V filed Critical Vivoryon Therapeutics N V
Publication of BR112021024327A2 publication Critical patent/BR112021024327A2/pt

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

inibidores heteroaromáticos de astacina proteinases. a presente invenção refere-se a novos derivados de ácido hidroxâmico úteis como inibidores de astacina metaloproteinases, em particular enzimas c-proteinase de procolágeno (pcp), meprinas, ovastacina e/ou astacinas nematoides; mais particularmente meprina a, meprina ß, bmp-1, ovastacina e/ou dpy-31 humana ou de mamífero de nematoides; composições farmacêuticas compreendendo tais compostos; métodos de tratamento ou profilaxia de doenças ou condições, principalmente os relacionados às referidas metaloproteinases; e compostos e composições farmacêuticas para uso em tais métodos.
BR112021024327A 2019-06-14 2020-06-12 Inibidores heteroaromáticos de astacina proteinases BR112021024327A2 (pt)

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