CA3300715A1 - Hydroxamic acid heteroaromatic derivatives and pharmaceutical compositions thereof useful as inhibitors of astacin proteinases - Google Patents

Hydroxamic acid heteroaromatic derivatives and pharmaceutical compositions thereof useful as inhibitors of astacin proteinases

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Publication number
CA3300715A1
CA3300715A1 CA3300715A CA3300715A CA3300715A1 CA 3300715 A1 CA3300715 A1 CA 3300715A1 CA 3300715 A CA3300715 A CA 3300715A CA 3300715 A CA3300715 A CA 3300715A CA 3300715 A1 CA3300715 A1 CA 3300715A1
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Canada
Prior art keywords
astacin
proteinases
inhibitors
useful
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3300715A
Other languages
English (en)
Inventor
Daniel Ramsbeck
Kathrin TAN
Dagmar Schlenzig
Mirko Buchholz
Holger Cynis
Stephan Schilling
Original Assignee
Vivoryon Therapeutics NV
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Filing date
Publication date
Application filed by Vivoryon Therapeutics NV filed Critical Vivoryon Therapeutics NV
Publication of CA3300715A1 publication Critical patent/CA3300715A1/en
Pending legal-status Critical Current

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
BRPI0811651A2 (pt) 2007-05-18 2014-11-11 Inhibox Ltd Composto, composição farmacêutica, métodos para preparar uma composição farmacêutica, para tratar uma doença, distúrbio ou condição, para inibir a tace em uma célula, in vitro ou in vivo, e de regular (por exemplo, inibir) a liberação da citocina (por exemplo, a liberação da tnf-alfa) em uma célula, in vitro ou in vivo, uso de um composto, e, kit
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EP3750878A1 (en) 2020-12-16
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EP3750878B1 (en) 2025-05-14
EP3750878C0 (en) 2025-05-14
SG11202112905UA (en) 2021-12-30
JP2022536183A (ja) 2022-08-12
KR20220024216A (ko) 2022-03-03
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KR20260036022A (ko) 2026-03-13
AU2020291114B2 (en) 2025-12-18
KR102930913B1 (ko) 2026-02-27
CN114585608A (zh) 2022-06-03
CN114585608B (zh) 2026-03-17
JP2025165966A (ja) 2025-11-05
IL288851B2 (en) 2026-02-01
BR112021024327A2 (pt) 2022-01-11
IL323353A (en) 2025-11-01
CA3142992A1 (en) 2020-12-17
WO2020249760A1 (en) 2020-12-17
US20250388544A1 (en) 2025-12-25
US20230122243A1 (en) 2023-04-20
IL288851A (en) 2022-02-01
MX2025005324A (es) 2025-06-02
EP3986868A1 (en) 2022-04-27
IL288851B1 (en) 2025-10-01
JP7773377B2 (ja) 2025-11-19
MX2021015324A (es) 2022-04-06

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