IL285399B2 - Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia - Google Patents
Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomiaInfo
- Publication number
- IL285399B2 IL285399B2 IL285399A IL28539921A IL285399B2 IL 285399 B2 IL285399 B2 IL 285399B2 IL 285399 A IL285399 A IL 285399A IL 28539921 A IL28539921 A IL 28539921A IL 285399 B2 IL285399 B2 IL 285399B2
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- pyridin
- amino
- chloro
- thieno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962805283P | 2019-02-13 | 2019-02-13 | |
| PCT/US2020/017430 WO2020167628A1 (en) | 2019-02-13 | 2020-02-10 | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL285399A IL285399A (en) | 2021-09-30 |
| IL285399B1 IL285399B1 (en) | 2025-02-01 |
| IL285399B2 true IL285399B2 (en) | 2025-06-01 |
Family
ID=69960696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL285399A IL285399B2 (en) | 2019-02-13 | 2020-02-10 | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12384797B2 (https=) |
| EP (1) | EP3924049A1 (https=) |
| JP (1) | JP7587511B2 (https=) |
| KR (1) | KR102907028B1 (https=) |
| CN (1) | CN113795304A (https=) |
| AU (1) | AU2020222881C1 (https=) |
| BR (1) | BR112021015853A2 (https=) |
| CA (1) | CA3129067A1 (https=) |
| CL (1) | CL2021002137A1 (https=) |
| CO (1) | CO2021010598A2 (https=) |
| EA (1) | EA202192170A1 (https=) |
| IL (1) | IL285399B2 (https=) |
| MX (1) | MX2021009667A (https=) |
| PE (1) | PE20220139A1 (https=) |
| SG (1) | SG11202108519TA (https=) |
| UA (1) | UA129890C2 (https=) |
| WO (1) | WO2020167628A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020167624A1 (en) | 2019-02-13 | 2020-08-20 | Ptc Therapeutics, Inc. | Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia |
| SG11202108519TA (en) | 2019-02-13 | 2021-09-29 | Ptc Therapeutics Inc | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia |
| CN115209955A (zh) * | 2019-12-12 | 2022-10-18 | Ptc医疗公司 | 治疗家族性自主神经功能障碍的化合物 |
| BR112022023025A2 (pt) | 2020-05-13 | 2023-03-28 | Chdi Foundation Inc | Moduladores de htt para tratar doença de huntington |
| EP4277626A4 (en) * | 2021-01-14 | 2024-12-11 | Georgetown University | USP13 INHIBITORS AND METHODS OF USE THEREOF |
| CN112920053B (zh) * | 2021-02-01 | 2022-07-01 | 暨明医药科技（苏州）有限公司 | 一种手性α-甲基芳乙胺的制备方法 |
| EP4288059A4 (en) * | 2021-02-05 | 2025-01-08 | PTC Therapeutics, Inc. | Compounds for treating spinocerebellar ataxia type 3 |
| US20240041886A1 (en) * | 2021-02-05 | 2024-02-08 | Ptc Therapeutics, Inc. | Methods for treating spinocerebellar ataxia type 3 |
| US20240051968A1 (en) * | 2021-02-05 | 2024-02-15 | Ptc Therapeutics, Inc. | Methods for treating spinocerebellar ataxia type 3 |
| TW202313623A (zh) | 2021-06-03 | 2023-04-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 具有整合酶抑制活性的吡啶酮化合物及其藥用用途 |
| EP4398987A4 (en) * | 2021-09-07 | 2025-07-09 | Ptc Therapeutics Inc | METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASES |
| US20250127789A1 (en) * | 2021-11-04 | 2025-04-24 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| US12281116B2 (en) | 2021-11-17 | 2025-04-22 | Chdi Foundation, Inc. | HTT modulators for treating Huntington's disease |
| WO2023212237A1 (en) | 2022-04-27 | 2023-11-02 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| US20260001889A1 (en) | 2022-05-12 | 2026-01-01 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| MA71255A (fr) * | 2022-06-22 | 2025-04-30 | Ptc Therapeutics, Inc. | Composés pour le traitement de l'ataxie spinocérébelleuse de type 3 |
| WO2024036143A2 (en) * | 2022-08-09 | 2024-02-15 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3020829A1 (en) * | 2013-07-12 | 2016-05-18 | Kyoto University | Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease |
| WO2016115434A1 (en) * | 2015-01-16 | 2016-07-21 | The General Hospital Corporation | Compounds for improving mrna splicing |
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| DE1470356A1 (de) | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| JP3126541B2 (ja) | 1993-03-26 | 2001-01-22 | 千寿製薬株式会社 | ベンゾチアゾール誘導体、その製法及びその用途 |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| NZ335823A (en) | 1997-04-22 | 2001-06-29 | Neurocrine Biosciences Inc | Thiophenopyridines, preparation as CRF receptor antagonists |
| EP1028964A1 (en) | 1997-11-11 | 2000-08-23 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| CL2003002287A1 (es) | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
| WO2004065392A1 (en) | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| WO2005007083A2 (en) | 2003-06-18 | 2005-01-27 | Smithkline Beecham Corporation | Chemical compounds |
| CA2540681C (en) | 2003-10-03 | 2014-08-12 | The General Hospital Corporation | Methods for altering mrna splicing and treating familial dysautonomia and other mechanistically related disorders |
| JP2009007341A (ja) | 2007-06-01 | 2009-01-15 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| EP2014663A1 (de) | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma AG | Thienopyrimidylamine als Modulatoren des EP2-Rezeptors |
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| BRPI0912245A2 (pt) | 2008-03-05 | 2019-09-24 | Takeda Pharmaceuticals Co | composto, prodroga, medicamento, métodos de suprimir produção de açúcar em um mamífero e para a profilaxia ou o tratamento de diabetes em um mamífero, e, uso do composto |
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| CN110218727A (zh) | 2013-03-14 | 2019-09-10 | 萨勒普塔医疗公司 | 用于治疗肌营养不良的外显子跳跃组合物 |
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| KR102390370B1 (ko) | 2014-02-12 | 2022-04-26 | 삼성전자주식회사 | 축합환 화합물 및 이를 포함한 유기 발광 소자 |
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| SG11202108519TA (en) | 2019-02-13 | 2021-09-29 | Ptc Therapeutics Inc | Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia |
| WO2020167624A1 (en) | 2019-02-13 | 2020-08-20 | Ptc Therapeutics, Inc. | Pyrrolo[2,3-d]pyrimidine compounds for treating familial dysautonomia |
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| US20240051968A1 (en) | 2021-02-05 | 2024-02-15 | Ptc Therapeutics, Inc. | Methods for treating spinocerebellar ataxia type 3 |
| EP4288059A4 (en) | 2021-02-05 | 2025-01-08 | PTC Therapeutics, Inc. | Compounds for treating spinocerebellar ataxia type 3 |
| EP4288441A4 (en) | 2021-02-05 | 2024-12-11 | PTC Therapeutics, Inc. | Methods for treating spinocerebellar ataxia type 3 |
| JP2024513566A (ja) | 2021-04-09 | 2024-03-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | 標的基質の選択的修飾のための二官能性分子 |
| EP4398987A4 (en) | 2021-09-07 | 2025-07-09 | Ptc Therapeutics Inc | METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASES |
| CN118251225A (zh) | 2021-09-07 | 2024-06-25 | Ptc医疗公司 | 治疗神经退行性疾病的方法 |
| MX2024002887A (es) | 2021-09-07 | 2024-05-28 | Ptc Therapeutics Inc | Metodos para tratar enfermedades neurodegenerativas. |
| US20250127789A1 (en) | 2021-11-04 | 2025-04-24 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| MA71255A (fr) | 2022-06-22 | 2025-04-30 | Ptc Therapeutics, Inc. | Composés pour le traitement de l'ataxie spinocérébelleuse de type 3 |
-
2020
- 2020-02-10 SG SG11202108519TA patent/SG11202108519TA/en unknown
- 2020-02-10 BR BR112021015853-7A patent/BR112021015853A2/pt unknown
- 2020-02-10 WO PCT/US2020/017430 patent/WO2020167628A1/en not_active Ceased
- 2020-02-10 KR KR1020217028864A patent/KR102907028B1/ko active Active
- 2020-02-10 MX MX2021009667A patent/MX2021009667A/es unknown
- 2020-02-10 UA UAA202105103A patent/UA129890C2/uk unknown
- 2020-02-10 IL IL285399A patent/IL285399B2/en unknown
- 2020-02-10 US US17/430,511 patent/US12384797B2/en active Active
- 2020-02-10 EA EA202192170A patent/EA202192170A1/ru unknown
- 2020-02-10 EP EP20714017.9A patent/EP3924049A1/en active Pending
- 2020-02-10 PE PE2021001329A patent/PE20220139A1/es unknown
- 2020-02-10 CA CA3129067A patent/CA3129067A1/en active Pending
- 2020-02-10 CN CN202080028449.2A patent/CN113795304A/zh active Pending
- 2020-02-10 AU AU2020222881A patent/AU2020222881C1/en active Active
- 2020-02-10 JP JP2021547446A patent/JP7587511B2/ja active Active
-
2021
- 2021-08-12 CL CL2021002137A patent/CL2021002137A1/es unknown
- 2021-08-12 CO CONC2021/0010598A patent/CO2021010598A2/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3020829A1 (en) * | 2013-07-12 | 2016-05-18 | Kyoto University | Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease |
| WO2016115434A1 (en) * | 2015-01-16 | 2016-07-21 | The General Hospital Corporation | Compounds for improving mrna splicing |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021015853A2 (pt) | 2021-10-05 |
| PE20220139A1 (es) | 2022-01-27 |
| UA129890C2 (uk) | 2025-09-03 |
| IL285399B1 (en) | 2025-02-01 |
| CL2021002137A1 (es) | 2022-02-25 |
| AU2020222881B2 (en) | 2025-07-10 |
| WO2020167628A1 (en) | 2020-08-20 |
| KR20210137040A (ko) | 2021-11-17 |
| JP7587511B2 (ja) | 2024-11-20 |
| US12384797B2 (en) | 2025-08-12 |
| AU2020222881C1 (en) | 2026-01-22 |
| EP3924049A1 (en) | 2021-12-22 |
| KR102907028B1 (ko) | 2026-01-05 |
| US20220135586A1 (en) | 2022-05-05 |
| CO2021010598A2 (es) | 2021-08-30 |
| AU2020222881A1 (en) | 2021-09-09 |
| CA3129067A1 (en) | 2020-08-20 |
| EA202192170A1 (ru) | 2021-11-15 |
| IL285399A (en) | 2021-09-30 |
| SG11202108519TA (en) | 2021-09-29 |
| JP2022520822A (ja) | 2022-04-01 |
| MX2021009667A (es) | 2021-12-10 |
| CN113795304A (zh) | 2021-12-14 |
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