CA3129067A1 - Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia - Google Patents

Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia Download PDF

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Publication number
CA3129067A1
CA3129067A1 CA3129067A CA3129067A CA3129067A1 CA 3129067 A1 CA3129067 A1 CA 3129067A1 CA 3129067 A CA3129067 A CA 3129067A CA 3129067 A CA3129067 A CA 3129067A CA 3129067 A1 CA3129067 A1 CA 3129067A1
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CA
Canada
Prior art keywords
methyl
pyridin
amino
chloro
thieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3129067A
Other languages
English (en)
French (fr)
Inventor
Nanjing Zhang
Michael A. Arnold
Amal DAKKA
Gary Mitchell Karp
Tom Tuan LUONG
Jana Narasimhan
Nikolai A. Naryshkin
Jiashi WANG
Xiaoyan Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PTC Therapeutics Inc
Original Assignee
PTC Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PTC Therapeutics Inc filed Critical PTC Therapeutics Inc
Publication of CA3129067A1 publication Critical patent/CA3129067A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3129067A 2019-02-13 2020-02-10 Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia Pending CA3129067A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962805283P 2019-02-13 2019-02-13
US62/805,283 2019-02-13
PCT/US2020/017430 WO2020167628A1 (en) 2019-02-13 2020-02-10 Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia

Publications (1)

Publication Number Publication Date
CA3129067A1 true CA3129067A1 (en) 2020-08-20

Family

ID=69960696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3129067A Pending CA3129067A1 (en) 2019-02-13 2020-02-10 Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia

Country Status (17)

Country Link
US (1) US12384797B2 (https=)
EP (1) EP3924049A1 (https=)
JP (1) JP7587511B2 (https=)
KR (1) KR102907028B1 (https=)
CN (1) CN113795304A (https=)
AU (1) AU2020222881C1 (https=)
BR (1) BR112021015853A2 (https=)
CA (1) CA3129067A1 (https=)
CL (1) CL2021002137A1 (https=)
CO (1) CO2021010598A2 (https=)
EA (1) EA202192170A1 (https=)
IL (1) IL285399B2 (https=)
MX (1) MX2021009667A (https=)
PE (1) PE20220139A1 (https=)
SG (1) SG11202108519TA (https=)
UA (1) UA129890C2 (https=)
WO (1) WO2020167628A1 (https=)

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Also Published As

Publication number Publication date
BR112021015853A2 (pt) 2021-10-05
PE20220139A1 (es) 2022-01-27
UA129890C2 (uk) 2025-09-03
IL285399B2 (en) 2025-06-01
IL285399B1 (en) 2025-02-01
CL2021002137A1 (es) 2022-02-25
AU2020222881B2 (en) 2025-07-10
WO2020167628A1 (en) 2020-08-20
KR20210137040A (ko) 2021-11-17
JP7587511B2 (ja) 2024-11-20
US12384797B2 (en) 2025-08-12
AU2020222881C1 (en) 2026-01-22
EP3924049A1 (en) 2021-12-22
KR102907028B1 (ko) 2026-01-05
US20220135586A1 (en) 2022-05-05
CO2021010598A2 (es) 2021-08-30
AU2020222881A1 (en) 2021-09-09
EA202192170A1 (ru) 2021-11-15
IL285399A (en) 2021-09-30
SG11202108519TA (en) 2021-09-29
JP2022520822A (ja) 2022-04-01
MX2021009667A (es) 2021-12-10
CN113795304A (zh) 2021-12-14

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