IL281811B2 - Thieno[3,2-B]pyridine derivatives as UPD glycosyltransferase inhibitors and methods of use - Google Patents
Thieno[3,2-B]pyridine derivatives as UPD glycosyltransferase inhibitors and methods of useInfo
- Publication number
- IL281811B2 IL281811B2 IL281811A IL28181121A IL281811B2 IL 281811 B2 IL281811 B2 IL 281811B2 IL 281811 A IL281811 A IL 281811A IL 28181121 A IL28181121 A IL 28181121A IL 281811 B2 IL281811 B2 IL 281811B2
- Authority
- IL
- Israel
- Prior art keywords
- thieno
- trifluoromethyl
- pyridin
- methylcarbamoyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862739405P | 2018-10-01 | 2018-10-01 | |
| PCT/US2019/054085 WO2020072504A1 (en) | 2018-10-01 | 2019-10-01 | Thieno[3,2-b]pyridine derivatives as udp glycosyltransferase inhibitors and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL281811A IL281811A (en) | 2021-05-31 |
| IL281811B1 IL281811B1 (en) | 2024-11-01 |
| IL281811B2 true IL281811B2 (en) | 2025-03-01 |
Family
ID=68296740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281811A IL281811B2 (en) | 2018-10-01 | 2019-10-01 | Thieno[3,2-B]pyridine derivatives as UPD glycosyltransferase inhibitors and methods of use |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11098056B2 (https=) |
| EP (1) | EP3861000A1 (https=) |
| JP (1) | JP7545979B2 (https=) |
| KR (1) | KR102903997B1 (https=) |
| CN (1) | CN113423711B (https=) |
| AU (1) | AU2019355870B2 (https=) |
| BR (1) | BR112021005914A2 (https=) |
| CA (1) | CA3114722A1 (https=) |
| CO (1) | CO2021005738A2 (https=) |
| IL (1) | IL281811B2 (https=) |
| MA (1) | MA53043B2 (https=) |
| MX (1) | MX2021003794A (https=) |
| SG (1) | SG11202102987VA (https=) |
| TW (1) | TWI821426B (https=) |
| WO (1) | WO2020072504A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202302565A (zh) * | 2021-02-19 | 2023-01-16 | 英商卡爾維斯塔製藥有限公司 | 酶抑制劑 |
| EP4483954A1 (en) * | 2023-06-29 | 2025-01-01 | Masarykova Univerzita | Substituted thieno [3,2-b]pyridines as inhibitors of protein kinases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001010842A2 (en) * | 1999-08-04 | 2001-02-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| WO2009062258A1 (en) * | 2007-11-15 | 2009-05-22 | Cytopia Research Pty Ltd | N-containing heterocyclic compounds |
| WO2017112777A1 (en) * | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| WO2017192930A1 (en) * | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3763156A (en) * | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
| MX2011008276A (es) * | 2009-02-06 | 2011-12-14 | Elan Pharm Inc | Inhibidores de quinasa jun n-terminal. |
| JP2014511391A (ja) * | 2011-03-07 | 2014-05-15 | フォンダッツィオーネ・テレソン | Ｔｆｅｂリン酸化阻害剤およびその使用 |
| ES2928714T3 (es) * | 2015-01-16 | 2022-11-22 | Massachusetts Gen Hospital | Compuestos para mejorar el empalme del ARNm |
| WO2017214505A1 (en) * | 2016-06-10 | 2017-12-14 | Biomarin Pharmaceutical Inc. | Ceramide galactosyltransferase inhibitors for the treatment of disease |
| MY193511A (en) * | 2016-11-02 | 2022-10-17 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
| WO2018118838A1 (en) * | 2016-12-20 | 2018-06-28 | Biomarin Pharmaceutical Inc. | Ceramide galactosyltransferase inhibitors for the treatment of disease |
| EP3619209A1 (en) * | 2017-05-04 | 2020-03-11 | Glenmark Pharmaceuticals S.A. | Substituted bicyclic heterocyclic compounds as nadph oxidase inhibitors |
| JP7514005B2 (ja) | 2017-06-21 | 2024-07-10 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物 |
-
2019
- 2019-10-01 SG SG11202102987VA patent/SG11202102987VA/en unknown
- 2019-10-01 EP EP19791011.0A patent/EP3861000A1/en active Pending
- 2019-10-01 CA CA3114722A patent/CA3114722A1/en active Pending
- 2019-10-01 CN CN201980076707.1A patent/CN113423711B/zh active Active
- 2019-10-01 AU AU2019355870A patent/AU2019355870B2/en active Active
- 2019-10-01 IL IL281811A patent/IL281811B2/en unknown
- 2019-10-01 KR KR1020217013167A patent/KR102903997B1/ko active Active
- 2019-10-01 WO PCT/US2019/054085 patent/WO2020072504A1/en not_active Ceased
- 2019-10-01 US US16/590,027 patent/US11098056B2/en active Active
- 2019-10-01 BR BR112021005914-8A patent/BR112021005914A2/pt unknown
- 2019-10-01 MA MA53043A patent/MA53043B2/fr unknown
- 2019-10-01 JP JP2021542086A patent/JP7545979B2/ja active Active
- 2019-10-01 MX MX2021003794A patent/MX2021003794A/es unknown
- 2019-10-01 TW TW108135781A patent/TWI821426B/zh active
-
2021
- 2021-04-29 CO CONC2021/0005738A patent/CO2021005738A2/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001010842A2 (en) * | 1999-08-04 | 2001-02-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| WO2009062258A1 (en) * | 2007-11-15 | 2009-05-22 | Cytopia Research Pty Ltd | N-containing heterocyclic compounds |
| WO2017112777A1 (en) * | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| WO2017192930A1 (en) * | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022508523A (ja) | 2022-01-19 |
| US11098056B2 (en) | 2021-08-24 |
| MX2021003794A (es) | 2021-09-08 |
| BR112021005914A2 (pt) | 2021-06-29 |
| AU2019355870B2 (en) | 2023-11-16 |
| SG11202102987VA (en) | 2021-04-29 |
| MA53043A1 (fr) | 2022-08-31 |
| TW202035419A (zh) | 2020-10-01 |
| IL281811A (en) | 2021-05-31 |
| EP3861000A1 (en) | 2021-08-11 |
| KR20210087033A (ko) | 2021-07-09 |
| AU2019355870A1 (en) | 2021-05-20 |
| CA3114722A1 (en) | 2020-04-09 |
| IL281811B1 (en) | 2024-11-01 |
| MA53043B2 (fr) | 2024-05-31 |
| CN113423711B (zh) | 2024-03-15 |
| KR102903997B1 (ko) | 2025-12-26 |
| US20200102324A1 (en) | 2020-04-02 |
| WO2020072504A1 (en) | 2020-04-09 |
| TWI821426B (zh) | 2023-11-11 |
| CN113423711A (zh) | 2021-09-21 |
| CO2021005738A2 (es) | 2021-05-10 |
| JP7545979B2 (ja) | 2024-09-05 |
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