IL280354A - Compositions comprising circular polyribonucleotides and uses thereof - Google Patents
Compositions comprising circular polyribonucleotides and uses thereofInfo
- Publication number
- IL280354A IL280354A IL280354A IL28035421A IL280354A IL 280354 A IL280354 A IL 280354A IL 280354 A IL280354 A IL 280354A IL 28035421 A IL28035421 A IL 28035421A IL 280354 A IL280354 A IL 280354A
- Authority
- IL
- Israel
- Prior art keywords
- preparations containing
- containing circular
- circular polyribonucleotides
- polyribonucleotides
- preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/532—Closed or circular
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862702714P | 2018-07-24 | 2018-07-24 | |
| US201962823569P | 2019-03-25 | 2019-03-25 | |
| US201962863670P | 2019-06-19 | 2019-06-19 | |
| PCT/US2019/043272 WO2020023655A1 (en) | 2018-07-24 | 2019-07-24 | Compositions comprising circular polyribonucleotides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL280354A true IL280354A (en) | 2021-03-25 |
Family
ID=69182387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL280354A IL280354A (en) | 2018-07-24 | 2021-01-24 | Compositions comprising circular polyribonucleotides and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210292761A1 (enExample) |
| EP (1) | EP3827084A4 (enExample) |
| JP (2) | JP2021531022A (enExample) |
| KR (1) | KR102950624B1 (enExample) |
| CN (2) | CN122146706A (enExample) |
| AU (2) | AU2019312269A1 (enExample) |
| BR (1) | BR112021001343A2 (enExample) |
| CA (1) | CA3107683A1 (enExample) |
| IL (1) | IL280354A (enExample) |
| MX (1) | MX2021000965A (enExample) |
| SG (1) | SG11202100750XA (enExample) |
| WO (1) | WO2020023655A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017222911A1 (en) | 2016-06-20 | 2017-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Circular rnas and their use in immunomodulation |
| CN110612353A (zh) | 2017-03-03 | 2019-12-24 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| MX2020006150A (es) | 2017-12-15 | 2020-11-11 | Flagship Pioneering Innovations Vi Llc | Composiciones que comprenden polirribonucleotidos circulares y usos de las mismas. |
| JP7618577B2 (ja) | 2019-03-25 | 2025-01-21 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 修飾環状ポリリボヌクレオチドを含む組成物及びその使用 |
| US12636369B2 (en) | 2019-06-19 | 2026-05-26 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
| US20220288176A1 (en) * | 2019-08-28 | 2022-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Circular rna modification and methods of use |
| US11827880B2 (en) | 2019-12-02 | 2023-11-28 | Shape Therapeutics Inc. | Therapeutic editing |
| TW202142689A (zh) | 2020-01-29 | 2021-11-16 | 美商旗艦先鋒創新有限責任公司 | 用於轉譯之組合物及其使用方法 |
| CN111500681A (zh) * | 2020-03-20 | 2020-08-07 | 青岛大学 | 用于检测piRNA与mRNA结合的可视化方法及其应用 |
| WO2021236952A1 (en) * | 2020-05-20 | 2021-11-25 | Flagship Pioneering, Inc. | Compositions and methods for producing human polyclonal antibodies |
| KR20230028375A (ko) | 2020-06-25 | 2023-02-28 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 원형 rna 번역을 구동하는 유전 요소와 이를 사용하는 방법 |
| CN116194581A (zh) * | 2020-07-01 | 2023-05-30 | 艾勒维生技公司 | 使用环状rna进行细胞重编程的组合物和方法 |
| CN113249811B (zh) * | 2021-05-13 | 2022-11-08 | 太原理工大学 | 一种中空纳米纤维内部固定化生物酶的制备方法 |
| JP2024521304A (ja) | 2021-05-18 | 2024-05-31 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 環状ポリリボヌクレオチドを濃縮する方法 |
| EP4341423A1 (en) | 2021-05-18 | 2024-03-27 | Flagship Pioneering Innovations VI, LLC | Methods of enriching for circular polyribonucleotides |
| AU2022285744A1 (en) * | 2021-06-02 | 2023-12-14 | Beam Therapeutics Inc. | Circular guide rnas for crispr/cas editing systems |
| JP2024528469A (ja) * | 2021-06-25 | 2024-07-30 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 組換え環状ｒｎａからの改良されたタンパク質翻訳のための組成物及び方法 |
| CN113264842B (zh) | 2021-07-21 | 2022-03-01 | 苏州科锐迈德生物医药科技有限公司 | 一种脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| KR20240047986A (ko) | 2021-07-27 | 2024-04-12 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 가공을 위한 디바이스, 시스템 및 방법 |
| CN114591986A (zh) * | 2021-07-29 | 2022-06-07 | 苏州科锐迈德生物医药科技有限公司 | 环状rna分子及其在目标蛋白的靶向降解中的应用 |
| AR127073A1 (es) | 2021-09-17 | 2023-12-13 | Flagship Pioneering Innovations Vi Llc | Composiciones y métodos para producir polirribonucleótidos circulares |
| CN116103284B (zh) * | 2021-11-09 | 2025-09-23 | 中国科学院天津工业生物技术研究所 | 环形gRNA及其相关生物材料与应用 |
| CN118510896A (zh) | 2021-12-17 | 2024-08-16 | 旗舰创业创新六公司 | 用于在变性条件下富集环状rna的方法 |
| JP2026503676A (ja) | 2023-01-27 | 2026-01-29 | セイル バイオメディシンズ インコーポレイテッド | 修飾脂質組成物およびその使用 |
| KR102968720B1 (ko) * | 2023-12-14 | 2026-05-26 | 한국과학기술원 | Circular RNA를 이용한 표적 mRNA 발현 저해 |
| WO2026096919A1 (en) | 2024-11-01 | 2026-05-07 | Sail Biomedicines, Inc. | Novel dipepetide core lipids, lipid carriers, and methods of using thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR604101A0 (en) * | 2001-06-29 | 2001-07-26 | Unisearch Limited | Aptamers |
| US20100003753A1 (en) * | 2005-08-01 | 2010-01-07 | Purdue Research Foundation | Multivalent rna nanoparticles for delivery of active agents to a cell |
| US20110065086A1 (en) | 2008-02-21 | 2011-03-17 | Otc Biotechnologies, Llc | Methods of producing homogeneous plastic-adherent aptamer-magnetic bead-fluorophore and other sandwich assays |
| ES2728782T3 (es) * | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| CN106133138A (zh) | 2013-08-22 | 2016-11-16 | 先锋国际良种公司 | 使用引导多核苷酸/cas内切核酸酶系统的基因组修饰及其使用方法 |
| EP3464596B1 (en) * | 2016-06-07 | 2025-07-30 | Cepheid | Thermostable polymerase inhibitor compositions and methods |
| US12636369B2 (en) * | 2019-06-19 | 2026-05-26 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
-
2019
- 2019-07-24 KR KR1020217005234A patent/KR102950624B1/ko active Active
- 2019-07-24 US US17/262,591 patent/US20210292761A1/en active Pending
- 2019-07-24 JP JP2021504230A patent/JP2021531022A/ja not_active Withdrawn
- 2019-07-24 WO PCT/US2019/043272 patent/WO2020023655A1/en not_active Ceased
- 2019-07-24 CN CN202511971333.3A patent/CN122146706A/zh active Pending
- 2019-07-24 EP EP19840286.9A patent/EP3827084A4/en active Pending
- 2019-07-24 MX MX2021000965A patent/MX2021000965A/es unknown
- 2019-07-24 AU AU2019312269A patent/AU2019312269A1/en not_active Abandoned
- 2019-07-24 SG SG11202100750XA patent/SG11202100750XA/en unknown
- 2019-07-24 BR BR112021001343-1A patent/BR112021001343A2/pt unknown
- 2019-07-24 CA CA3107683A patent/CA3107683A1/en active Pending
- 2019-07-24 CN CN201980051856.2A patent/CN112567038A/zh active Pending
-
2021
- 2021-01-24 IL IL280354A patent/IL280354A/en unknown
-
2024
- 2024-09-13 JP JP2024159028A patent/JP2024169484A/ja active Pending
-
2026
- 2026-02-19 AU AU2026201251A patent/AU2026201251A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210039401A (ko) | 2021-04-09 |
| BR112021001343A2 (pt) | 2021-05-04 |
| US20210292761A1 (en) | 2021-09-23 |
| EP3827084A1 (en) | 2021-06-02 |
| AU2026201251A1 (en) | 2026-03-12 |
| EP3827084A4 (en) | 2023-03-15 |
| SG11202100750XA (en) | 2021-02-25 |
| CN122146706A (zh) | 2026-06-05 |
| JP2024169484A (ja) | 2024-12-05 |
| CA3107683A1 (en) | 2020-01-30 |
| WO2020023655A1 (en) | 2020-01-30 |
| KR102950624B1 (ko) | 2026-04-10 |
| CN112567038A (zh) | 2021-03-26 |
| JP2021531022A (ja) | 2021-11-18 |
| AU2019312269A1 (en) | 2021-03-04 |
| MX2021000965A (es) | 2021-06-15 |
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