IL276409A - Methods and preparations for macrophage polarization - Google Patents
Methods and preparations for macrophage polarizationInfo
- Publication number
- IL276409A IL276409A IL276409A IL27640920A IL276409A IL 276409 A IL276409 A IL 276409A IL 276409 A IL276409 A IL 276409A IL 27640920 A IL27640920 A IL 27640920A IL 276409 A IL276409 A IL 276409A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- methods
- macrophage polarization
- macrophage
- polarization
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C12N2509/10—Mechanical dissociation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862629563P | 2018-02-12 | 2018-02-12 | |
| PCT/US2019/017731 WO2019157535A1 (en) | 2018-02-12 | 2019-02-12 | Methods and compositions for macrophage polarization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL276409A true IL276409A (en) | 2020-09-30 |
Family
ID=65729420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL276409A IL276409A (en) | 2018-02-12 | 2020-07-30 | Methods and preparations for macrophage polarization |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11512315B2 (enExample) |
| EP (2) | EP3752615B1 (enExample) |
| JP (2) | JP2021512608A (enExample) |
| KR (1) | KR20200120624A (enExample) |
| CN (2) | CN119614501A (enExample) |
| AU (1) | AU2019218991A1 (enExample) |
| BR (1) | BR112020016228A2 (enExample) |
| CA (1) | CA3088009A1 (enExample) |
| CL (1) | CL2020002053A1 (enExample) |
| CO (1) | CO2020009694A2 (enExample) |
| EA (1) | EA202091486A1 (enExample) |
| IL (1) | IL276409A (enExample) |
| MX (1) | MX2020008103A (enExample) |
| PH (1) | PH12020551195A1 (enExample) |
| SG (1) | SG11202006021SA (enExample) |
| TW (1) | TW202003846A (enExample) |
| WO (1) | WO2019157535A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019218991A1 (en) | 2018-02-12 | 2020-07-09 | Lonza Sales Ag | Methods and compositions for macrophage polarization |
| AU2019242912B2 (en) | 2018-03-28 | 2025-07-17 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| US12312584B2 (en) | 2018-10-02 | 2025-05-27 | Exosome Therapeutics, Inc. | cGMP exosome loaded therapeutics for treating sickle cell disease |
| WO2020106772A1 (en) * | 2018-11-19 | 2020-05-28 | Exosome Therapeutics, Inc. | Exosome loaded therapeutics for the treatment of non-alcoholic steatohepatitis, diabetes mellitus type 1 and type 2, atherosclerotic cardiovascular disease, and alpha 1 antitrypsin deficiency |
| KR20220078565A (ko) * | 2019-08-14 | 2022-06-10 | 코디악 바이오사이언시즈, 인크. | 분자에 연결된 세포외 소포 및 이의 용도 |
| WO2021030769A1 (en) * | 2019-08-14 | 2021-02-18 | Codiak Biosciences, Inc. | Extracellular vesicles with nras antisense oligonucleotides |
| JP2022544289A (ja) * | 2019-08-14 | 2022-10-17 | コディアック バイオサイエンシーズ, インコーポレイテッド | Stat6を標的とする細胞外小胞-aso構築物 |
| CN114641570A (zh) * | 2019-08-14 | 2022-06-17 | 科迪亚克生物科学公司 | 具有靶向kras的反义寡核苷酸的细胞外囊泡 |
| BR112022002690A2 (pt) * | 2019-08-14 | 2022-08-23 | Codiak Biosciences Inc | Construtos de vesícula-aso extracelular tendo como alvo cebp/beta |
| JP2022549328A (ja) * | 2019-09-25 | 2022-11-24 | コディアック バイオサイエンシーズ, インコーポレイテッド | 細胞外小胞組成物 |
| CN115297850A (zh) * | 2019-12-05 | 2022-11-04 | 得克萨斯州大学系统董事会 | 用于肝纤维化和其他与纤维化相关的疾病的基于外排体的治疗 |
| CN115768877A (zh) | 2020-05-11 | 2023-03-07 | 斯特姆生物公司 | 与巨核细胞来源的细胞外囊泡相关的组合物和方法 |
| WO2021237100A1 (en) * | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| CN111748523B (zh) * | 2020-07-17 | 2022-11-22 | 南通大学 | 一种免疫调节小胞外囊泡的制备方法及其用途 |
| WO2022076596A1 (en) * | 2020-10-06 | 2022-04-14 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
| US20230405118A1 (en) * | 2020-10-30 | 2023-12-21 | The George Washington University, A Congressionally Chartered Not-For-Profit Corporation | Stat-activated macrophages, compositions, and uses thereof |
| AU2022216260A1 (en) * | 2021-02-03 | 2023-08-17 | Research Institute At Nationwide Children's Hospital | Compositions and methods for treating disease associated with dux4 overexpression |
| US12521449B2 (en) | 2021-04-26 | 2026-01-13 | Strm.Bio Incorporated | Compositions and methods related to megakaryocyte-derived extracellular vesicles for Fanconi Anemia |
| CN113262305B (zh) * | 2021-05-27 | 2022-03-25 | 浙江大学 | Coro1a基因作为靶点在制备抗肿瘤药物中的应用 |
| EP4365175A4 (en) | 2021-07-02 | 2025-06-25 | Spark Biopharma, Inc. | Novel benzopyran derivative and use thereof |
| CN113521252B (zh) * | 2021-07-29 | 2022-12-20 | 南开大学 | Tnfsf15蛋白作为巨噬细胞免疫增强剂的用途及其活化方法 |
| US20240392293A1 (en) * | 2021-09-02 | 2024-11-28 | Molecular Axiom, Llc | Compositions and methods for modulating kras expression |
| CN118434857A (zh) * | 2021-10-21 | 2024-08-02 | 纳诺瑟拉生物科学股份有限公司 | 用于沉默kras的组合物以及方法 |
| CN114058621B (zh) * | 2021-12-03 | 2023-06-16 | 温州医科大学 | 一种lncRNA基因修饰细胞分泌的外泌体及应用 |
| CN114209814B (zh) * | 2021-12-15 | 2024-02-23 | 南开大学 | Tnfsf15蛋白在促进骨髓干细胞分化为巨噬细胞并扩增中的用途 |
| CN114561347A (zh) * | 2022-02-25 | 2022-05-31 | 和携科技有限公司 | 一种脂肪间充质干细胞的培养基和培养方法 |
| CN115948496A (zh) * | 2022-04-15 | 2023-04-11 | 健艾仕生物医药科技(杭州)有限公司 | 一种巨噬细胞极化过程高通量检测的方法及应用 |
| CN115137708B (zh) * | 2022-06-24 | 2023-05-16 | 重庆医科大学 | 装载yap1核酸序列的肝纤维化靶向纳米颗粒及其制备方法和应用 |
| EP4554984A1 (en) * | 2022-07-13 | 2025-05-21 | Navidea Biopharmaceuticals, Inc. | Mannosylated amine dextran drug delivery vehicles with degradable disulfide/carbonate linkers targeting payloads to cd206 expressing cells |
| CN115261410A (zh) * | 2022-07-20 | 2022-11-01 | 中山大学 | 一种基因编辑工程化m1型巨噬细胞外泌体的制备方法及其应用 |
| EP4599252A2 (en) * | 2022-08-26 | 2025-08-13 | Georgia State University Research Foundation, Inc. | Treating chronic inflammation and cancer by macrophage polarization |
| CN115814108B (zh) * | 2022-12-27 | 2025-04-25 | 华中科技大学 | 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法 |
| CN116370647B (zh) * | 2023-04-11 | 2025-07-11 | 吉林大学 | 一种用于胰腺癌免疫治疗的工程化外泌体及制备方法 |
| CN119215144B (zh) * | 2023-09-08 | 2025-08-08 | 首都医科大学附属北京朝阳医院 | Lrg1在制备促进巨噬细胞向m1型分化的药物中的应用和巨噬细胞激活剂 |
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| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
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| DE102004026309A1 (de) * | 2004-05-26 | 2005-12-29 | Haarlems Allergenen Laboratorium B.V. | Pharamzeutische Zusammensetzung zur Behandlung allergischer Erkrankungen, pathologischer Atemswegsveränderungen und von Krebs durch Modulation der Genexpression des Stat6 |
| DE102006050655A1 (de) * | 2006-10-24 | 2008-04-30 | Halmon Beheer B.V. | Pharmazeutische Zusammensetzung zur Behandlung allergischer Erkrankungen |
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| US20160243192A1 (en) * | 2013-10-17 | 2016-08-25 | Children's Hospital Los Angeles | Antibody dependent exosome therapy |
| US20160346334A1 (en) * | 2014-02-05 | 2016-12-01 | Stc.Unm | Exosomes as a therapeutic for cancer |
| ES2727154T3 (es) * | 2014-10-24 | 2019-10-14 | Astrazeneca Ab | Combinación |
| IL256175B2 (en) * | 2015-06-10 | 2024-10-01 | Univ Texas | Using exosomes to treat the disease |
| GB201516801D0 (en) * | 2015-09-22 | 2015-11-04 | Immunovia Ab | Method, array and use thereof |
| HK1255699A1 (zh) * | 2015-09-24 | 2019-08-23 | Ionis Pharmaceuticals, Inc. | Kras表达的调节剂 |
| SG10202008883SA (en) * | 2016-03-15 | 2020-10-29 | Codiak Biosciences Inc | Therapeutic membrane vesicles |
| US12622876B2 (en) | 2016-08-22 | 2026-05-12 | Lonza Sales Ag | Methods of suppressing delivery of exosomes to liver and spleen |
| MX2020001790A (es) | 2017-08-25 | 2020-07-22 | Codiak Biosciences Inc | Preparacion de exosomas terapeuticos mediante el uso de proteinas de membrana. |
| AU2019218991A1 (en) | 2018-02-12 | 2020-07-09 | Lonza Sales Ag | Methods and compositions for macrophage polarization |
| KR20220078565A (ko) * | 2019-08-14 | 2022-06-10 | 코디악 바이오사이언시즈, 인크. | 분자에 연결된 세포외 소포 및 이의 용도 |
| US20210322405A1 (en) * | 2020-04-15 | 2021-10-21 | Washington University | Compositions and methods for treating cancer |
| JP2025509183A (ja) * | 2022-03-04 | 2025-04-11 | アイ-エムエービー バイオファーマ ユーエス リミテッド | がんの処置のためのkras阻害剤を含む併用療法 |
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2019
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- 2019-02-12 US US16/969,511 patent/US11512315B2/en active Active
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- 2019-02-12 MX MX2020008103A patent/MX2020008103A/es unknown
- 2019-02-12 CN CN202411511570.7A patent/CN119614501A/zh active Pending
- 2019-02-12 JP JP2020542161A patent/JP2021512608A/ja not_active Ceased
- 2019-02-12 KR KR1020207022341A patent/KR20200120624A/ko not_active Ceased
- 2019-02-12 CA CA3088009A patent/CA3088009A1/en active Pending
- 2019-02-12 SG SG11202006021SA patent/SG11202006021SA/en unknown
- 2019-02-12 BR BR112020016228-0A patent/BR112020016228A2/pt not_active IP Right Cessation
- 2019-02-12 WO PCT/US2019/017731 patent/WO2019157535A1/en not_active Ceased
- 2019-02-12 TW TW108104676A patent/TW202003846A/zh unknown
- 2019-02-12 CN CN201980011011.0A patent/CN111918967B/zh active Active
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2020
- 2020-07-30 IL IL276409A patent/IL276409A/en unknown
- 2020-08-05 CO CONC2020/0009694A patent/CO2020009694A2/es unknown
- 2020-08-06 PH PH12020551195A patent/PH12020551195A1/en unknown
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2022
- 2022-11-04 US US18/052,785 patent/US12570978B2/en active Active
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2024
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| Publication number | Publication date |
|---|---|
| WO2019157535A1 (en) | 2019-08-15 |
| CL2020002053A1 (es) | 2020-12-18 |
| PH12020551195A1 (en) | 2021-08-16 |
| TW202003846A (zh) | 2020-01-16 |
| US12570978B2 (en) | 2026-03-10 |
| EP4663245A3 (en) | 2026-04-29 |
| CN119614501A (zh) | 2025-03-14 |
| CN111918967A (zh) | 2020-11-10 |
| EA202091486A1 (ru) | 2021-02-08 |
| BR112020016228A2 (pt) | 2020-12-08 |
| JP2024166292A (ja) | 2024-11-28 |
| MX2020008103A (es) | 2020-09-25 |
| US11512315B2 (en) | 2022-11-29 |
| AU2019218991A1 (en) | 2020-07-09 |
| JP2021512608A (ja) | 2021-05-20 |
| CO2020009694A2 (es) | 2020-10-30 |
| KR20200120624A (ko) | 2020-10-21 |
| SG11202006021SA (en) | 2020-08-28 |
| EP3752615B1 (en) | 2025-08-27 |
| US20200407725A1 (en) | 2020-12-31 |
| CA3088009A1 (en) | 2019-08-15 |
| US20230365971A1 (en) | 2023-11-16 |
| EP4663245A2 (en) | 2025-12-17 |
| EP3752615A1 (en) | 2020-12-23 |
| CN111918967B (zh) | 2024-11-19 |
| EP3752615C0 (en) | 2025-08-27 |
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