IL275748B2 - Processes and intermediates for the preparation of cyclase-based geonalite fans - Google Patents

Processes and intermediates for the preparation of cyclase-based geonalite fans

Info

Publication number
IL275748B2
IL275748B2 IL275748A IL27574820A IL275748B2 IL 275748 B2 IL275748 B2 IL 275748B2 IL 275748 A IL275748 A IL 275748A IL 27574820 A IL27574820 A IL 27574820A IL 275748 B2 IL275748 B2 IL 275748B2
Authority
IL
Israel
Prior art keywords
formula
compound
appropriate amount
solvent
base
Prior art date
Application number
IL275748A
Other languages
English (en)
Hebrew (he)
Other versions
IL275748A (en
IL275748B1 (en
Original Assignee
Cyclerion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2018/076982 external-priority patent/WO2019161534A1/en
Application filed by Cyclerion Therapeutics Inc filed Critical Cyclerion Therapeutics Inc
Publication of IL275748A publication Critical patent/IL275748A/en
Publication of IL275748B1 publication Critical patent/IL275748B1/en
Publication of IL275748B2 publication Critical patent/IL275748B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/245Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL275748A 2018-01-10 2019-01-10 Processes and intermediates for the preparation of cyclase-based geonalite fans IL275748B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862615678P 2018-01-10 2018-01-10
PCT/CN2018/076982 WO2019161534A1 (en) 2018-02-22 2018-02-22 Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators
PCT/US2019/013060 WO2019140095A1 (en) 2018-01-10 2019-01-10 Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators

Publications (3)

Publication Number Publication Date
IL275748A IL275748A (en) 2020-08-31
IL275748B1 IL275748B1 (en) 2024-09-01
IL275748B2 true IL275748B2 (en) 2025-01-01

Family

ID=65279655

Family Applications (3)

Application Number Title Priority Date Filing Date
IL275748A IL275748B2 (en) 2018-01-10 2019-01-10 Processes and intermediates for the preparation of cyclase-based geonalite fans
IL314714A IL314714A (en) 2018-01-10 2019-01-10 Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators
IL319883A IL319883A (en) 2018-01-10 2019-01-10 Processes and intermediates for the preparation of cyclase-based geonalite fans

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL314714A IL314714A (en) 2018-01-10 2019-01-10 Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators
IL319883A IL319883A (en) 2018-01-10 2019-01-10 Processes and intermediates for the preparation of cyclase-based geonalite fans

Country Status (17)

Country Link
US (5) US11274096B2 (https=)
EP (3) EP4249469A3 (https=)
JP (2) JP7357621B2 (https=)
KR (3) KR102739727B1 (https=)
CN (3) CN118221665A (https=)
AU (3) AU2019206560B2 (https=)
BR (1) BR112020013985A2 (https=)
CA (1) CA3087943A1 (https=)
CL (3) CL2020001814A1 (https=)
ES (1) ES2963447T3 (https=)
IL (3) IL275748B2 (https=)
JO (1) JOP20200165A1 (https=)
MA (2) MA71753A (https=)
MX (3) MX2020007364A (https=)
SG (1) SG11202006311SA (https=)
TW (2) TWI888947B (https=)
WO (1) WO2019140095A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109563077B (zh) 2016-07-07 2026-03-10 赛克里翁治疗有限公司 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
MA71753A (fr) 2018-01-10 2025-05-30 Cyclerion Therapeutics, Inc. Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble
EP4640676A1 (en) * 2022-12-21 2025-10-29 Sunshine Lake Pharma Co., Ltd. Crystal form of fluorine-substituted indazole compound and use thereof
AU2023412238A1 (en) * 2022-12-21 2025-07-03 Sunshine Lake Pharma Co., Ltd. Crystal form of fluorine-substituted indazole compound and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044447A1 (en) * 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
WO2017095697A1 (en) * 2015-11-30 2017-06-08 Ironwood Pharmaceuticals, Inc. Solid dispersions comprising a sgc stimulator

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR088020A1 (es) * 2010-06-30 2014-05-07 Ironwood Pharmaceuticals Inc Compuestos heterociclicos como estimuladores de sgc
SI2970243T1 (sl) * 2013-03-15 2020-04-30 Cyclerion Therapeutics, Inc. SGC stimulatorji
WO2015106268A1 (en) * 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
KR20170055531A (ko) * 2014-09-17 2017-05-19 아이언우드 파마슈티컬스, 인코포레이티드 에스지씨 자극제
CN109563077B (zh) 2016-07-07 2026-03-10 赛克里翁治疗有限公司 用于制备可溶性鸟苷酸环化酶刺激剂的新方法
WO2018009602A2 (en) 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Novel processes for preparation of soluble guanylate cyclase stimulators
MA71753A (fr) 2018-01-10 2025-05-30 Cyclerion Therapeutics, Inc. Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044447A1 (en) * 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
WO2017095697A1 (en) * 2015-11-30 2017-06-08 Ironwood Pharmaceuticals, Inc. Solid dispersions comprising a sgc stimulator

Also Published As

Publication number Publication date
KR20250048609A (ko) 2025-04-09
TW201932450A (zh) 2019-08-16
US20220024909A1 (en) 2022-01-27
KR20250002720A (ko) 2025-01-07
AU2019206560B2 (en) 2023-08-24
SG11202006311SA (en) 2020-07-29
EP3737679C0 (en) 2023-09-06
IL275748A (en) 2020-08-31
IL314714A (en) 2024-10-01
AU2023270260B2 (en) 2026-01-29
EP3737679B1 (en) 2023-09-06
KR102739727B1 (ko) 2024-12-05
CN118184645A (zh) 2024-06-14
MX2023000045A (es) 2023-02-01
EP3737679A1 (en) 2020-11-18
MX2023000044A (es) 2023-02-01
KR20200106920A (ko) 2020-09-15
CN111902410A (zh) 2020-11-06
CN118221665A (zh) 2024-06-21
EP4570797A2 (en) 2025-06-18
US12275724B2 (en) 2025-04-15
BR112020013985A2 (pt) 2020-12-01
US20250361228A1 (en) 2025-11-27
US11708361B2 (en) 2023-07-25
EP4570797A3 (en) 2025-09-03
AU2025202281A9 (en) 2025-05-15
AU2019206560A1 (en) 2020-07-30
US20230339928A1 (en) 2023-10-26
MX2020007364A (es) 2020-11-18
CA3087943A1 (en) 2019-07-18
TWI888947B (zh) 2025-07-01
AU2023270260A1 (en) 2023-12-07
EP4249469A3 (en) 2023-12-27
US12030874B2 (en) 2024-07-09
JP2021511299A (ja) 2021-05-06
AU2025202281A1 (en) 2025-04-17
JP7357621B2 (ja) 2023-10-06
JP7744955B2 (ja) 2025-09-26
US20240391911A1 (en) 2024-11-28
MA51565A (fr) 2020-11-18
CL2020001814A1 (es) 2020-11-06
TWI821237B (zh) 2023-11-11
WO2019140095A8 (en) 2020-06-18
US11274096B2 (en) 2022-03-15
CN111902410B (zh) 2024-04-19
CL2022000907A1 (es) 2022-10-21
ES2963447T3 (es) 2024-03-27
IL275748B1 (en) 2024-09-01
EP4249469A2 (en) 2023-09-27
JP2023182647A (ja) 2023-12-26
TW202402741A (zh) 2024-01-16
MA71753A (fr) 2025-05-30
CL2022000904A1 (es) 2022-10-21
WO2019140095A1 (en) 2019-07-18
US20210053962A1 (en) 2021-02-25
JOP20200165A1 (ar) 2022-10-30
IL319883A (en) 2025-05-01

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