IL274323B2 - Genetic modification of cytokine inducible sh2-containing protein (cish) gene - Google Patents
Genetic modification of cytokine inducible sh2-containing protein (cish) geneInfo
- Publication number
- IL274323B2 IL274323B2 IL274323A IL27432320A IL274323B2 IL 274323 B2 IL274323 B2 IL 274323B2 IL 274323 A IL274323 A IL 274323A IL 27432320 A IL27432320 A IL 27432320A IL 274323 B2 IL274323 B2 IL 274323B2
- Authority
- IL
- Israel
- Prior art keywords
- seq
- sbs
- cell
- zinc finger
- genetically modified
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title claims 9
- 238000012239 gene modification Methods 0.000 title 1
- 230000005017 genetic modification Effects 0.000 title 1
- 235000013617 genetically modified food Nutrition 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims 27
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 101710185494 Zinc finger protein Proteins 0.000 claims 7
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 101150043532 CISH gene Proteins 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 101710163270 Nuclease Proteins 0.000 claims 4
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 4
- 108700019146 Transgenes Proteins 0.000 claims 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 3
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 238000013461 design Methods 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 239000011701 zinc Substances 0.000 claims 3
- 229910052725 zinc Inorganic materials 0.000 claims 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 230000004568 DNA-binding Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762583724P | 2017-11-09 | 2017-11-09 | |
| US201862716002P | 2018-08-08 | 2018-08-08 | |
| PCT/US2018/060038 WO2019094725A2 (en) | 2017-11-09 | 2018-11-09 | Genetic modification of cytokine inducible sh2-containing protein (cish) gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL274323A IL274323A (en) | 2020-06-30 |
| IL274323B1 IL274323B1 (en) | 2024-06-01 |
| IL274323B2 true IL274323B2 (en) | 2024-10-01 |
Family
ID=66328332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL274323A IL274323B2 (en) | 2017-11-09 | 2018-11-09 | Genetic modification of cytokine inducible sh2-containing protein (cish) gene |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11661611B2 (enExample) |
| EP (1) | EP3706766A4 (enExample) |
| JP (2) | JP2021502085A (enExample) |
| KR (1) | KR102730214B1 (enExample) |
| CN (1) | CN111565730B (enExample) |
| AU (2) | AU2018364660B2 (enExample) |
| BR (1) | BR112020008568A2 (enExample) |
| CA (1) | CA3079748A1 (enExample) |
| IL (1) | IL274323B2 (enExample) |
| MX (1) | MX2020004907A (enExample) |
| SG (1) | SG11202004003YA (enExample) |
| WO (1) | WO2019094725A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| WO2017023803A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
| GB2573664B (en) * | 2016-10-27 | 2022-09-28 | Intima Bioscience Inc | Viral methods of T cell therapy |
| CA3051113A1 (en) * | 2017-01-26 | 2018-08-02 | Sangamo Therapeutics, Inc. | B-cell engineering |
| BR112020009889A2 (pt) | 2017-12-14 | 2020-11-03 | Flodesign Sonics, Inc. | acionador e controlador de transdutor acústico |
| WO2020172555A1 (en) * | 2019-02-21 | 2020-08-27 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| US20250027107A1 (en) | 2021-10-18 | 2025-01-23 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| CN118256444A (zh) * | 2022-04-26 | 2024-06-28 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其制备方法和应用 |
| AU2023347831A1 (en) * | 2022-09-19 | 2025-04-10 | Emendobio Inc. | Biallelic knockout of cish |
| KR20240131525A (ko) * | 2023-02-23 | 2024-09-02 | 이엔셀 주식회사 | Nk 세포 공여 소스의 선별방법 |
| WO2024186971A1 (en) * | 2023-03-07 | 2024-09-12 | Intellia Therapeutics, Inc. | Cish compositions and methods for immunotherapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017023803A1 (en) * | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
| US20170281682A1 (en) * | 2014-09-09 | 2017-10-05 | Unum Therapeutics Inc. | Chimeric receptors and uses thereof in immune therapy |
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2018
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- 2018-11-09 KR KR1020207016374A patent/KR102730214B1/ko active Active
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- 2018-11-09 SG SG11202004003YA patent/SG11202004003YA/en unknown
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- 2018-11-09 CA CA3079748A patent/CA3079748A1/en active Pending
- 2018-11-09 WO PCT/US2018/060038 patent/WO2019094725A2/en not_active Ceased
- 2018-11-09 BR BR112020008568-5A patent/BR112020008568A2/pt not_active Application Discontinuation
- 2018-11-09 CN CN201880085867.8A patent/CN111565730B/zh active Active
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2023
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20170281682A1 (en) * | 2014-09-09 | 2017-10-05 | Unum Therapeutics Inc. | Chimeric receptors and uses thereof in immune therapy |
| WO2017023803A1 (en) * | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
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| US20190136261A1 (en) | 2019-05-09 |
| MX2020004907A (es) | 2020-09-09 |
| CA3079748A1 (en) | 2019-05-16 |
| IL274323A (en) | 2020-06-30 |
| BR112020008568A2 (pt) | 2020-10-06 |
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| JP2021502085A (ja) | 2021-01-28 |
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| WO2019094725A3 (en) | 2019-06-20 |
| KR20200079539A (ko) | 2020-07-03 |
| CN111565730B (zh) | 2024-09-17 |
| AU2018364660A1 (en) | 2020-05-14 |
| IL274323B1 (en) | 2024-06-01 |
| AU2018364660B2 (en) | 2022-05-19 |
| EP3706766A4 (en) | 2021-08-18 |
| US20230272415A1 (en) | 2023-08-31 |
| SG11202004003YA (en) | 2020-05-28 |
| KR102730214B1 (ko) | 2024-11-13 |
| JP2024009129A (ja) | 2024-01-19 |
| CN111565730A (zh) | 2020-08-21 |
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