IL271901A - Anti-CD8 antibodies and their uses - Google Patents
Anti-CD8 antibodies and their usesInfo
- Publication number
- IL271901A IL271901A IL271901A IL27190120A IL271901A IL 271901 A IL271901 A IL 271901A IL 271901 A IL271901 A IL 271901A IL 27190120 A IL27190120 A IL 27190120A IL 271901 A IL271901 A IL 271901A
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762536239P | 2017-07-24 | 2017-07-24 | |
US201862660902P | 2018-04-20 | 2018-04-20 | |
PCT/US2018/043343 WO2019023148A1 (en) | 2017-07-24 | 2018-07-23 | ANTI-CD8 ANTIBODIES AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
IL271901A true IL271901A (en) | 2020-02-27 |
Family
ID=63143411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL271901A IL271901A (en) | 2017-07-24 | 2020-01-08 | Anti-CD8 antibodies and their uses |
Country Status (17)
Country | Link |
---|---|
US (3) | US10730944B2 (es) |
EP (1) | EP3658193A1 (es) |
JP (2) | JP7304846B2 (es) |
KR (1) | KR20200031645A (es) |
CN (1) | CN110997013B (es) |
AU (1) | AU2018307744A1 (es) |
BR (1) | BR112020001360A2 (es) |
CA (1) | CA3070796A1 (es) |
CL (1) | CL2020000192A1 (es) |
CO (1) | CO2020000680A2 (es) |
IL (1) | IL271901A (es) |
MA (1) | MA49683A (es) |
MX (1) | MX2020000916A (es) |
MY (1) | MY197688A (es) |
PH (1) | PH12020550008A1 (es) |
SG (1) | SG11202000073XA (es) |
WO (1) | WO2019023148A1 (es) |
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CA3167285A1 (en) * | 2020-01-10 | 2021-07-15 | Fusion Pharmaceuticals Inc. | Sustained immunotherapy |
CN113563473A (zh) * | 2020-04-29 | 2021-10-29 | 三生国健药业(上海)股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
CN111413298A (zh) * | 2020-05-27 | 2020-07-14 | 深圳市天安至远传感科技有限公司 | 一种光纤表面等离子体共振传感器、制备方法及检测系统 |
CN116723857A (zh) * | 2020-07-21 | 2023-09-08 | 苏州智核生物医药科技有限公司 | Cd8结合多肽及其用途 |
KR20230050389A (ko) | 2020-08-13 | 2023-04-14 | 브리스톨-마이어스 스큅 컴퍼니 | Il-2를 관심 표적 세포로 재지시하는 방법 |
CN114112868A (zh) * | 2020-08-26 | 2022-03-01 | 上海睿昂基因科技股份有限公司 | 一种用于监测肿瘤相关免疫微环境的流式细胞术试剂盒及监测方法 |
MX2023004598A (es) * | 2020-10-23 | 2023-06-29 | Asher Biotherapeutics Inc | Fusiones con moléculas de unión al antígeno cd8 para modular la función de las células inmunitarias. |
US20220241328A1 (en) | 2021-01-11 | 2022-08-04 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
KR20240028975A (ko) * | 2021-04-08 | 2024-03-05 | 사나 바이오테크놀로지, 인크. | Cd8-특이적 항체 구조체들 및 이의 조성물 |
EP4346882A1 (en) * | 2021-05-26 | 2024-04-10 | Oxford BioTherapeutics Ltd | Pharmaceutical combination comprising an anti-cd205 antibody and an immune checkpoint inhibitor |
CN114230665B (zh) * | 2021-06-23 | 2024-03-22 | 苏州智核生物医药科技有限公司 | CD8α结合多肽及其用途 |
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WO2023034569A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
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WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
CN115337413B (zh) * | 2022-08-08 | 2023-08-22 | 中国科学院近代物理研究所 | 一种针对非小细胞肺癌诊断的放射性分子探针的制备及应用 |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
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WO2017087826A1 (en) | 2015-11-18 | 2017-05-26 | Memorial Sloan Kettering Cancer Center | Systems, methods, and compositions for imaging androgen receptor axis activity in carcinoma, and related therapeutic compositions and methods |
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CN109963620A (zh) | 2016-06-06 | 2019-07-02 | 林克西斯有限公司 | 细胞靶向缀合物 |
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EP3510046A4 (en) | 2016-09-07 | 2020-05-06 | The Regents of the University of California | ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES |
CN110191721A (zh) | 2016-09-26 | 2019-08-30 | 集合集团控股公司 | 有淋巴系统失调的受试者中癌症的评估与治疗方法 |
US11103603B2 (en) | 2016-10-20 | 2021-08-31 | The University Of North Carolina At Chapel Hill | 18F-labeled compounds for PET imaging and uses thereof |
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2018
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- 2018-07-23 BR BR112020001360-9A patent/BR112020001360A2/pt unknown
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- 2018-07-23 EP EP18752377.4A patent/EP3658193A1/en active Pending
- 2018-07-23 US US16/043,048 patent/US10730944B2/en active Active
- 2018-07-23 KR KR1020207004275A patent/KR20200031645A/ko not_active Application Discontinuation
- 2018-07-23 MY MYPI2020000164A patent/MY197688A/en unknown
- 2018-07-23 WO PCT/US2018/043343 patent/WO2019023148A1/en unknown
- 2018-07-23 MX MX2020000916A patent/MX2020000916A/es unknown
- 2018-07-23 CN CN201880053140.1A patent/CN110997013B/zh active Active
- 2018-07-23 JP JP2020503721A patent/JP7304846B2/ja active Active
- 2018-07-23 AU AU2018307744A patent/AU2018307744A1/en active Pending
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2022
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CL2020000192A1 (es) | 2020-08-14 |
US20190023790A1 (en) | 2019-01-24 |
JP2020534250A (ja) | 2020-11-26 |
JP2023121798A (ja) | 2023-08-31 |
MX2020000916A (es) | 2020-09-10 |
KR20200031645A (ko) | 2020-03-24 |
US20230159639A1 (en) | 2023-05-25 |
BR112020001360A2 (pt) | 2020-08-11 |
MA49683A (fr) | 2020-06-03 |
JP7304846B2 (ja) | 2023-07-07 |
AU2018307744A1 (en) | 2020-02-13 |
US11525001B2 (en) | 2022-12-13 |
CN110997013B (zh) | 2022-09-20 |
CN110997013A (zh) | 2020-04-10 |
WO2019023148A1 (en) | 2019-01-31 |
US20210147542A1 (en) | 2021-05-20 |
EP3658193A1 (en) | 2020-06-03 |
CO2020000680A2 (es) | 2020-01-31 |
SG11202000073XA (en) | 2020-02-27 |
MY197688A (en) | 2023-07-05 |
CA3070796A1 (en) | 2019-01-31 |
PH12020550008A1 (en) | 2020-10-12 |
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