IL269846A - A test to measure the strength of receptor-ligand interactions in nanomedicines - Google Patents
A test to measure the strength of receptor-ligand interactions in nanomedicinesInfo
- Publication number
- IL269846A IL269846A IL26984619A IL26984619A IL269846A IL 269846 A IL269846 A IL 269846A IL 26984619 A IL26984619 A IL 26984619A IL 26984619 A IL26984619 A IL 26984619A IL 269846 A IL269846 A IL 269846A
- Authority
- IL
- Israel
- Prior art keywords
- nanomedicines
- potency
- assay
- receptor
- measure
- Prior art date
Links
- 238000003556 assay Methods 0.000 title 1
- 230000003993 interaction Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Nanotechnology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762483298P | 2017-04-07 | 2017-04-07 | |
| PCT/IB2018/000510 WO2018185564A2 (en) | 2017-04-07 | 2018-04-05 | Assay to measure the potency of receptor-ligand interactions in nanomedicines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL269846A true IL269846A (en) | 2019-11-28 |
Family
ID=63713282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL26984619A IL269846A (en) | 2017-04-07 | 2019-10-06 | A test to measure the strength of receptor-ligand interactions in nanomedicines |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20200057048A1 (https=) |
| EP (1) | EP3607058A4 (https=) |
| JP (2) | JP2020516594A (https=) |
| KR (1) | KR20200004807A (https=) |
| CN (1) | CN110945120B (https=) |
| AU (1) | AU2018248961B2 (https=) |
| BR (1) | BR112019021022A2 (https=) |
| CO (1) | CO2019011018A2 (https=) |
| IL (1) | IL269846A (https=) |
| MX (1) | MX2019012058A (https=) |
| RU (1) | RU2019135533A (https=) |
| SG (1) | SG11201909290TA (https=) |
| WO (1) | WO2018185564A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
| US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
| AU2014343379B2 (en) | 2013-11-04 | 2019-02-14 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
| EP3291832B1 (en) | 2015-05-06 | 2025-09-03 | UTI Limited Partnership | Nanoparticle compositions for sustained therapy |
| CA3083748A1 (en) | 2017-11-29 | 2019-06-06 | Uti Limited Partnership | Methods of treating autoimmune disease |
| EP3833681A1 (en) * | 2018-08-06 | 2021-06-16 | Medigene Immunotherapies GmbH | Ha-1 specific t cell receptors and their use |
| GB201906127D0 (en) * | 2019-05-01 | 2019-06-12 | Immutep S A | Assays |
| JP7731805B2 (ja) * | 2019-05-23 | 2025-09-01 | ユーティアイ・リミテッド・パートナーシップ | 肝疾患の治療方法 |
| US20210222178A1 (en) * | 2020-01-11 | 2021-07-22 | Sivec Biotechnologies Llc | MICROBIAL SYSTEM FOR PRODUCTION AND DELIVERY OF EUKARYOTE-TRANSLATABLE mRNA TO EUKARYA |
| WO2021216787A1 (en) * | 2020-04-21 | 2021-10-28 | Regeneron Pharmaceuticals, Inc. | Methods and systems for analysis of receptor interaction |
| AR122023A1 (es) * | 2020-05-06 | 2022-08-03 | Imcyse Sa | Péptidos y métodos para el tratamiento de esclerosis múltiple |
| WO2021231376A2 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| WO2022056014A1 (en) * | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
| EP4405465A4 (en) * | 2021-09-21 | 2025-12-24 | Univ Monash | TREATMENT METHODS |
| CN113960003B (zh) * | 2021-10-20 | 2023-10-24 | 吉林大学 | 基于dna银纳米簇和金纳米棒检测四环素的适配体传感器 |
| US11873507B2 (en) | 2021-11-29 | 2024-01-16 | Replicate Bioscience, Inc. | Compositions and methods for expression of IL-12 and IL-1RA |
| EP4249062A1 (en) * | 2022-03-24 | 2023-09-27 | Julius-Maximilians-Universität Würzburg | Mhc ib-mediated aquaporin 4 (aqp4)-specific immunosuppression as a novel treatment for nmo |
| CN115125205A (zh) * | 2022-06-14 | 2022-09-30 | 中国医学科学院生物医学工程研究所 | 一种修饰EpCAM抗体和/或CSV抗体的白细胞磁球及其制备方法 |
| WO2024248042A1 (ja) * | 2023-05-29 | 2024-12-05 | 国立大学法人 東京大学 | ＭｕＳＫを標的とする新規化合物及びその用途 |
| WO2025061917A1 (en) * | 2023-09-22 | 2025-03-27 | Julius-Maximilians-Universität Würzburg | Mhc ib-mediated aquaporin 4 (aqp4)-specific immunosuppression as a novel treatment for nmo |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US707993A (en) | 1901-05-16 | 1902-08-26 | Clinton J Warren | Machine for corking bottles. |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US6103379A (en) | 1994-10-06 | 2000-08-15 | Bar-Ilan University | Process for the preparation of microspheres and microspheres made thereby |
| WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| CA2328108A1 (en) | 1998-05-07 | 1999-11-11 | The Regents Of The University Of California | Use of neglected target tissue antigens in modulation of immune responses |
| US6150022A (en) | 1998-12-07 | 2000-11-21 | Flex Products, Inc. | Bright metal flake based pigments |
| US7419829B2 (en) | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
| KR100379250B1 (ko) | 2000-12-04 | 2003-04-08 | 한국과학기술연구원 | 나노 단위 크기의 금속 입자가 함유된 고분자 복합 소재및 그 제조 방법 |
| IL157335A0 (en) | 2001-03-13 | 2004-02-19 | Novartis Ag | Lentiviral packaging constructs |
| GB0417954D0 (en) * | 2004-08-12 | 2004-09-15 | Avidex Ltd | Cellulat TCR ligand assay method |
| CN101678090B (zh) | 2007-03-07 | 2012-04-11 | 乌第有限合伙公司 | 用于预防和治疗自身免疫病的组合物和方法 |
| WO2009027978A1 (en) | 2007-08-30 | 2009-03-05 | Hadasit Medical Research Services & Development Ltd. | NUCLEIC ACID SEQUENCES COMPRISING NF-ϰB BINDING SITE WITHIN O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER REGION AND USES THEREOF FOR THE TREATMENT OF CANCER AND IMMUNE-RELATED DISORDERS |
| EP2353004B1 (en) | 2008-11-12 | 2018-01-03 | Yeda Research and Development Co. Ltd. | Diagnosis of multiple sclerosis |
| EP2486049A1 (en) | 2009-10-06 | 2012-08-15 | The Board Of Trustees Of The UniversityOf Illinois | Human single-chain t cell receptors |
| KR20130124487A (ko) | 2010-09-29 | 2013-11-14 | 유티아이 리미티드 파트너쉽 | 생체적합성, 생흡수성 나노구를 사용하는 자가면역 질병의 치료방법 |
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| WO2013057586A1 (en) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions and methods for producing soluble t - cell receptors |
| US8809057B2 (en) * | 2012-01-04 | 2014-08-19 | Raytheon Bbn Technologies Corp. | Methods of evaluating gene expression levels |
| US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
| JP6014440B2 (ja) | 2012-09-26 | 2016-10-25 | 日立オートモティブシステムズ株式会社 | 移動物体認識装置 |
| AU2014343379B2 (en) | 2013-11-04 | 2019-02-14 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
| ES2905615T3 (es) * | 2014-11-20 | 2022-04-11 | Promega Corp | Sistemas y métodos para evaluar moduladores de puntos de control inmunitario |
| EP3851450B1 (en) * | 2014-12-19 | 2024-11-27 | ETH Zürich | Chimeric antigen receptors and methods of use |
| EP3067366A1 (en) * | 2015-03-13 | 2016-09-14 | Max-Delbrück-Centrum Für Molekulare Medizin | Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1 |
| AU2016243583B2 (en) * | 2015-03-27 | 2022-03-10 | President And Fellows Of Harvard College | Modified T cells and methods of making and using the same |
| EP3291832B1 (en) * | 2015-05-06 | 2025-09-03 | UTI Limited Partnership | Nanoparticle compositions for sustained therapy |
| EA201792660A1 (ru) * | 2015-06-01 | 2018-05-31 | Медиджин Иммьюнотерапиз Гмбх | Библиотека т-клеточных рецепторов |
| CA2996887A1 (en) * | 2015-09-11 | 2017-03-16 | Agenus Inc. | Engineered host cells and methods of use thereof |
-
2018
- 2018-04-05 WO PCT/IB2018/000510 patent/WO2018185564A2/en not_active Ceased
- 2018-04-05 AU AU2018248961A patent/AU2018248961B2/en active Active
- 2018-04-05 BR BR112019021022A patent/BR112019021022A2/pt not_active Application Discontinuation
- 2018-04-05 US US16/603,180 patent/US20200057048A1/en not_active Abandoned
- 2018-04-05 SG SG11201909290T patent/SG11201909290TA/en unknown
- 2018-04-05 JP JP2019554417A patent/JP2020516594A/ja active Pending
- 2018-04-05 CN CN201880038292.4A patent/CN110945120B/zh active Active
- 2018-04-05 KR KR1020197032951A patent/KR20200004807A/ko not_active Withdrawn
- 2018-04-05 EP EP18781139.3A patent/EP3607058A4/en active Pending
- 2018-04-05 RU RU2019135533A patent/RU2019135533A/ru not_active Application Discontinuation
- 2018-04-05 MX MX2019012058A patent/MX2019012058A/es unknown
-
2019
- 2019-10-04 CO CONC2019/0011018A patent/CO2019011018A2/es unknown
- 2019-10-06 IL IL26984619A patent/IL269846A/en unknown
-
2023
- 2023-09-01 US US18/459,960 patent/US20240201171A1/en active Pending
-
2024
- 2024-02-21 JP JP2024024899A patent/JP2024073459A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019012058A (es) | 2019-11-11 |
| WO2018185564A2 (en) | 2018-10-11 |
| US20240201171A1 (en) | 2024-06-20 |
| JP2020516594A (ja) | 2020-06-11 |
| KR20200004807A (ko) | 2020-01-14 |
| AU2018248961A1 (en) | 2019-10-31 |
| JP2024073459A (ja) | 2024-05-29 |
| AU2018248961B2 (en) | 2024-06-20 |
| SG11201909290TA (en) | 2019-11-28 |
| RU2019135533A (ru) | 2021-05-07 |
| CA3059016A1 (en) | 2018-10-11 |
| CO2019011018A2 (es) | 2019-10-21 |
| US20200057048A1 (en) | 2020-02-20 |
| BR112019021022A2 (pt) | 2020-06-09 |
| WO2018185564A3 (en) | 2019-01-03 |
| CN110945120A (zh) | 2020-03-31 |
| EP3607058A2 (en) | 2020-02-12 |
| CN110945120B (zh) | 2025-04-18 |
| EP3607058A4 (en) | 2020-12-16 |
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