IL266750A - Methods of enhancing immune response with everolimus, dactolisib or both - Google Patents

Methods of enhancing immune response with everolimus, dactolisib or both

Info

Publication number
IL266750A
IL266750A IL266750A IL26675019A IL266750A IL 266750 A IL266750 A IL 266750A IL 266750 A IL266750 A IL 266750A IL 26675019 A IL26675019 A IL 26675019A IL 266750 A IL266750 A IL 266750A
Authority
IL
Israel
Prior art keywords
dactolisib
everolimus
methods
immune response
enhancing immune
Prior art date
Application number
IL266750A
Other languages
English (en)
Hebrew (he)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL266750A publication Critical patent/IL266750A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL266750A 2016-11-23 2019-05-20 Methods of enhancing immune response with everolimus, dactolisib or both IL266750A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662425766P 2016-11-23 2016-11-23
US201762476160P 2017-03-24 2017-03-24
US201762576511P 2017-10-24 2017-10-24
PCT/IB2017/001579 WO2018096402A1 (en) 2016-11-23 2017-11-22 Methods of enhancing immune response with everolimus, dactolisib or both

Publications (1)

Publication Number Publication Date
IL266750A true IL266750A (en) 2019-07-31

Family

ID=60957348

Family Applications (1)

Application Number Title Priority Date Filing Date
IL266750A IL266750A (en) 2016-11-23 2019-05-20 Methods of enhancing immune response with everolimus, dactolisib or both

Country Status (12)

Country Link
US (3) US10441584B2 (enExample)
EP (1) EP3544608A1 (enExample)
JP (1) JP2020500930A (enExample)
KR (1) KR20190089005A (enExample)
CN (1) CN110114070A (enExample)
AU (1) AU2017363970A1 (enExample)
BR (1) BR112019010470A2 (enExample)
CA (1) CA3044355A1 (enExample)
IL (1) IL266750A (enExample)
MX (1) MX2019006090A (enExample)
TW (1) TW201825090A (enExample)
WO (1) WO2018096402A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016064683A1 (en) 2014-10-24 2016-04-28 St. Jude Children's Research Hospital Coordinated metabolic reprogramming in response to productive viral infections
CA3044355A1 (en) 2016-11-23 2018-05-31 Novartis Ag Methods of enhancing immune response with everolimus, dactolisib or both
WO2019157516A1 (en) 2018-02-12 2019-08-15 resTORbio, Inc. Combination therapies
WO2020223154A1 (en) * 2019-05-01 2020-11-05 resTORbio, Inc. Methods of enhancing immune response

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1028606A (en) 1912-06-04 Victor Talking Machine Co Sound-box for talking-machines.
US1000480A (en) 1909-05-19 1911-08-15 J G Brill Co Car-truck.
US1044158A (en) 1911-01-27 1912-11-12 Allen H Fetzer Trolley-wheel.
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
WO1995014023A1 (en) 1993-11-19 1995-05-26 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
ATE191218T1 (de) 1993-12-17 2000-04-15 Novartis Ag Rapamycin-derivate als immunosuppressoren
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5741677A (en) 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
PL184731B1 (pl) 1995-06-09 2002-12-31 Novartis Ag Pochodne rapamycyny, zastosowanie pochodnych rapamycyny i kompozycja farmaceutyczna
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
EP0937082A2 (en) 1996-07-12 1999-08-25 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
CA2230748C (en) 1997-03-14 2010-08-03 American Home Products Corporation Rapamycin formulations for oral administration
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
TW557297B (en) 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
DK2198858T3 (da) 1998-03-26 2011-10-03 Astellas Pharma Inc Præparat med opretholdt frigivelse af en makrolidforbindelse såsom tacrolimus
EP1212331B1 (en) 1999-08-24 2004-04-21 Ariad Gene Therapeutics, Inc. 28-epirapalogs
GB0008785D0 (en) 2000-04-10 2000-05-31 Novartis Ag Organic compounds
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
CN100522967C (zh) 2002-02-01 2009-08-05 阿里亚德基因治疗公司 含磷化合物及其应用
US20030203027A1 (en) 2002-04-26 2003-10-30 Ethicon, Inc. Coating technique for deposition of drug substance on a substrate
US7075204B2 (en) 2003-08-06 2006-07-11 Honeywell International, Inc. Threaded inner sleeve for generator magnet
AR045957A1 (es) 2003-10-03 2005-11-16 Novartis Ag Composicion farmaceutica y combinacion
US7220755B2 (en) 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
GB0419355D0 (en) 2004-08-31 2004-09-29 Novartis Ag Organic compounds
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
EP1853259A1 (en) 2005-02-09 2007-11-14 Macusight, Inc. Formulations for ocular treatment
AU2006222409A1 (en) 2005-03-08 2006-09-14 Lifecycle Pharma A/S Pharmaceutical compositions comprising sirolimus and/or an analogue thereof
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
EP2001466B1 (en) 2006-03-23 2016-01-06 Santen Pharmaceutical Co., Ltd Low-dose rapamycin for the treatment of vascular permeability-related diseases
US20100266590A1 (en) 2006-08-02 2010-10-21 Demetri George D Combination therapy
EP1902708A1 (de) 2006-09-25 2008-03-26 Losan Pharma GmbH Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung
RS53335B (sr) 2006-11-20 2014-10-31 Novartis Ag Kristalna monotozilatna so 2-metil-2-[4-(3-metil-2-okso-8-hinolin-3-il-2,3-dihidro-imidazo[4,5-c]hinolin-1-il)-fenil]-propionitrila
MX2009008486A (es) 2007-02-20 2009-08-20 Novartis Ag Imidazoquinolinas como inhibidores dobles de cinasa de lipido y mtor.
WO2009013305A1 (en) 2007-07-24 2009-01-29 Novartis Ag Use of imidazoquinolines for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
US20090082387A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched nvp-bez234
US20090088373A1 (en) 2007-09-28 2009-04-02 Gallo Richard L Use of compositions to enhance innate immune response
CN101969931A (zh) 2008-03-05 2011-02-09 万能药生物有限公司 包含霉酚酸的调节释放药物组合物及其方法
US20110020338A1 (en) 2008-03-26 2011-01-27 Carlos Garcia-Echeverria 5Imidazoquinolines and Pyrimidine Derivatives as Potent Modulators of VEGF-Driven Angiogenic Processes
US8840899B2 (en) 2008-08-05 2014-09-23 Emory University Use of mTOR inhibitors to enhance T cell immune responses
US8822647B2 (en) 2008-08-26 2014-09-02 City Of Hope Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
CN102202668A (zh) 2008-10-31 2011-09-28 诺瓦提斯公司 磷脂酰肌醇-3-激酶(PI3K)抑制剂和mTOR抑制剂的组合产品
DK2365802T3 (da) 2008-11-11 2017-11-13 Univ Texas Mikrokapsler af rapamycin og anvendelse til behandling af cancer
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
CN102281761A (zh) 2009-01-14 2011-12-14 健康研究股份有限公司 用于增强免疫应答的方法和含有mTOR抑制剂的组合物
US20100233733A1 (en) 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
RU2589823C2 (ru) 2009-04-09 2016-07-10 Алкермес Фарма Айэленд Лимитед Композиция для доставки лекарственных средств
ES2685947T3 (es) 2009-04-10 2018-10-15 Haiyan Qi Agentes antienvejecimiento
CN101862297B (zh) 2009-04-14 2012-07-25 上海医药工业研究院 一种非水溶性药物的缓释微丸、其缓释口腔崩解片及其制备方法
CA2760932A1 (en) 2009-05-04 2010-11-11 Thierry Nivaggioli Mtor pathway inhibitors for treating ocular disorders
PH12012500491A1 (en) 2009-09-09 2018-03-21 Celgene Avilomics Res Inc P13 kinase inhibitors and uses thereof
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
WO2012006619A2 (en) 2010-07-09 2012-01-12 Northeastern University ANTIPARASITIC AGENTS BASED ON mTOR INHIBITORS
AR083267A1 (es) 2010-10-04 2013-02-13 Novartis Ag Combinaciones farmaceuticas
CN103237544A (zh) 2010-12-03 2013-08-07 诺华有限公司 药物组合物
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
CA2825825A1 (en) 2011-01-27 2012-08-02 The Trustees Of Princeton University Inhibitors of mtor kinase as anti-viral agents
WO2012110953A1 (en) 2011-02-16 2012-08-23 Novartis Ag Combinations of therapeutic agents for use in the treatment of neurodegenerative diseases
CN102138903B (zh) 2011-03-17 2012-12-12 苏州特瑞药业有限公司 一种依维莫司固体口服药物组合物
US9358229B2 (en) 2011-08-10 2016-06-07 Novartis Pharma Ag JAK PI3K/mTOR combination therapy
CA2848065A1 (en) 2011-09-30 2013-04-04 Dana-Farber Cancer Institute, Inc. Method of treating mucoepidermoid carcinoma
EP2763663B1 (en) 2011-10-06 2017-12-27 Novartis AG Pharmaceutical compositions comprising 40-o-(2-hydroxy)ethyl-rapamycin
EP2638896A1 (en) 2012-03-14 2013-09-18 Bioneer A/S Cationic liposomal drug delivery system for specific targeting of human cd14+ monocytes in whole blood
HK1203393A1 (en) 2012-04-11 2015-10-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting b-cell maturation antigen
CA2872541A1 (en) 2012-06-06 2013-12-12 Novartis Ag Combination of a 17 -alpha -hydroxylase (c17, 20 - lyase) inhibitor and a specific pi-3k inhibitor for treating a tumor disease
WO2014137946A1 (en) 2013-03-04 2014-09-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of inhibiting igf-1r activation or downtream signalling thereof to reduce radiation-induced cellular senescence
TW201503912A (zh) 2013-03-19 2015-02-01 Novartis Ag 包含癌莫事（ｅｖｅｒｏｌｉｍｕｓ）之醫藥組合物
EP3004337B1 (en) 2013-05-29 2017-08-02 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
KR101582264B1 (ko) 2013-06-27 2016-01-04 삼성전자 주식회사 유기 박막용 조성물, 유기 박막 및 상기 유기 박막을 포함하는 전자 소자
US9033062B2 (en) * 2013-07-11 2015-05-19 Caterpillar Inc. Control system for a machine
JP2016537345A (ja) * 2013-11-13 2016-12-01 ノバルティス アーゲー 免疫応答を増強するためのｍＴＯＲ阻害剤
SI3151672T1 (sl) 2014-06-06 2021-03-31 Bluebird Bio, Inc. Izboljšani T-celični sestavki
KR102612313B1 (ko) 2014-07-21 2023-12-12 노파르티스 아게 인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료
US9777061B2 (en) 2014-07-21 2017-10-03 Novartis Ag Treatment of cancer using a CD33 chimeric antigen receptor
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
US20170274014A1 (en) 2014-07-21 2017-09-28 Jennifer Brogdon Combinations of low, immune enhancing, doses of mtor inhibitors and cars
CN107109420A (zh) 2014-07-21 2017-08-29 诺华股份有限公司 使用cll－1嵌合抗原受体的癌症治疗
PL3183268T3 (pl) 2014-08-19 2020-09-07 Novartis Ag Chimeryczny receptor antygenowy (CAR) anty-CD123 do zastosowania w leczeniu nowotworu złośliwego
WO2016064683A1 (en) * 2014-10-24 2016-04-28 St. Jude Children's Research Hospital Coordinated metabolic reprogramming in response to productive viral infections
WO2016079332A1 (en) 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for improving immunotherapy
WO2016185443A1 (en) * 2015-05-20 2016-11-24 Novartis Ag Pharmaceutical combination of everolimus with dactolisib
CA3044355A1 (en) 2016-11-23 2018-05-31 Novartis Ag Methods of enhancing immune response with everolimus, dactolisib or both

Also Published As

Publication number Publication date
WO2018096402A1 (en) 2018-05-31
BR112019010470A2 (pt) 2019-09-10
AU2017363970A1 (en) 2019-06-20
KR20190089005A (ko) 2019-07-29
JP2020500930A (ja) 2020-01-16
MX2019006090A (es) 2019-08-21
US20200061051A1 (en) 2020-02-27
US11045463B2 (en) 2021-06-29
US20200054624A1 (en) 2020-02-20
US20180161319A1 (en) 2018-06-14
CA3044355A1 (en) 2018-05-31
US10441584B2 (en) 2019-10-15
CN110114070A (zh) 2019-08-09
EP3544608A1 (en) 2019-10-02
US10993940B2 (en) 2021-05-04
TW201825090A (zh) 2018-07-16

Similar Documents

Publication Publication Date Title
GB2530726B (en) Distributed single sign-on
EP3175592A4 (en) Orthogonal differential vector signaling codes with embedded clock
AU201712948S (en) Catheter
GB201615128D0 (en) Methods
IL247614B (en) Methods and preparations for changing the immune response
GB201709075D0 (en) Methods
GB201610162D0 (en) Methods
PL3207273T3 (pl) Zespół amortyzatora
HUE049290T2 (hu) Leválasztó
GB201622086D0 (en) Biocontrol organism
GB201511969D0 (en) Biosensor
IL266750A (en) Methods of enhancing immune response with everolimus, dactolisib or both
GB201620668D0 (en) Demodulation
GB201621386D0 (en) Methods
IL264299A (en) safe box
EP3105458A4 (en) Garment weight clip
GB2567755C (en) Cooker
PT3335725T (pt) Epítopos pds5a como indutores de imunidade
GB201501523D0 (en) Differential immune response modulation
GB2549811B (en) Stove
GB201601868D0 (en) Methods
GB201519554D0 (en) Genetically modified microorganisms
GB2567330B (en) Cooker
GB201619945D0 (en) Methods
HK40014245A (en) Methods of enhancing immune response with everolimus, dactolisib or both