CN110114070A - 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法 - Google Patents

使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法 Download PDF

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Publication number
CN110114070A
CN110114070A CN201780080148.2A CN201780080148A CN110114070A CN 110114070 A CN110114070 A CN 110114070A CN 201780080148 A CN201780080148 A CN 201780080148A CN 110114070 A CN110114070 A CN 110114070A
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pharmaceutically acceptable
acceptable salt
bez235
rad001
patient
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English (en)
Chinese (zh)
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琼·曼尼克
梅洛迪·莫里斯
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780080148.2A 2016-11-23 2017-11-22 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法 Pending CN110114070A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662425766P 2016-11-23 2016-11-23
US62/425,766 2016-11-23
US201762476160P 2017-03-24 2017-03-24
US62/476,160 2017-03-24
US201762576511P 2017-10-24 2017-10-24
US62/576,511 2017-10-24
PCT/IB2017/001579 WO2018096402A1 (en) 2016-11-23 2017-11-22 Methods of enhancing immune response with everolimus, dactolisib or both

Publications (1)

Publication Number Publication Date
CN110114070A true CN110114070A (zh) 2019-08-09

Family

ID=60957348

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780080148.2A Pending CN110114070A (zh) 2016-11-23 2017-11-22 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法

Country Status (12)

Country Link
US (3) US10441584B2 (enExample)
EP (1) EP3544608A1 (enExample)
JP (1) JP2020500930A (enExample)
KR (1) KR20190089005A (enExample)
CN (1) CN110114070A (enExample)
AU (1) AU2017363970A1 (enExample)
BR (1) BR112019010470A2 (enExample)
CA (1) CA3044355A1 (enExample)
IL (1) IL266750A (enExample)
MX (1) MX2019006090A (enExample)
TW (1) TW201825090A (enExample)
WO (1) WO2018096402A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016064683A1 (en) 2014-10-24 2016-04-28 St. Jude Children's Research Hospital Coordinated metabolic reprogramming in response to productive viral infections
WO2018096402A1 (en) 2016-11-23 2018-05-31 Novartis Ag Methods of enhancing immune response with everolimus, dactolisib or both
WO2019157516A1 (en) 2018-02-12 2019-08-15 resTORbio, Inc. Combination therapies
WO2020223154A1 (en) * 2019-05-01 2020-11-05 resTORbio, Inc. Methods of enhancing immune response

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WO2016064683A1 (en) * 2014-10-24 2016-04-28 St. Jude Children's Research Hospital Coordinated metabolic reprogramming in response to productive viral infections
CN105899232A (zh) * 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂

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US20200054624A1 (en) 2020-02-20
US10441584B2 (en) 2019-10-15
EP3544608A1 (en) 2019-10-02
US20180161319A1 (en) 2018-06-14
KR20190089005A (ko) 2019-07-29
IL266750A (en) 2019-07-31
WO2018096402A1 (en) 2018-05-31
TW201825090A (zh) 2018-07-16
CA3044355A1 (en) 2018-05-31
JP2020500930A (ja) 2020-01-16
US10993940B2 (en) 2021-05-04
BR112019010470A2 (pt) 2019-09-10
US11045463B2 (en) 2021-06-29
AU2017363970A1 (en) 2019-06-20
MX2019006090A (es) 2019-08-21
US20200061051A1 (en) 2020-02-27

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