IL266187A - Treatment of gastric cancer using combined treatments containing liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin) - Google Patents
Treatment of gastric cancer using combined treatments containing liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin)Info
- Publication number
- IL266187A IL266187A IL266187A IL26618719A IL266187A IL 266187 A IL266187 A IL 266187A IL 266187 A IL266187 A IL 266187A IL 26618719 A IL26618719 A IL 26618719A IL 266187 A IL266187 A IL 266187A
- Authority
- IL
- Israel
- Prior art keywords
- fluoruracil
- leucovorin
- oxaliplatin
- gastric cancer
- combination therapies
- Prior art date
Links
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 title 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 title 1
- 208000005718 Stomach Neoplasms Diseases 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 229960002949 fluorouracil Drugs 0.000 title 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title 1
- 235000008191 folinic acid Nutrition 0.000 title 1
- 239000011672 folinic acid Substances 0.000 title 1
- 206010017758 gastric cancer Diseases 0.000 title 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 title 1
- 229960004768 irinotecan Drugs 0.000 title 1
- 229960001691 leucovorin Drugs 0.000 title 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 title 1
- 229960001756 oxaliplatin Drugs 0.000 title 1
- 201000011549 stomach cancer Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416317P | 2016-11-02 | 2016-11-02 | |
| PCT/GB2017/053293 WO2018083470A1 (en) | 2016-11-02 | 2017-11-01 | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL266187A true IL266187A (en) | 2019-06-30 |
Family
ID=60569939
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL266187A IL266187A (en) | 2016-11-02 | 2019-04-23 | Treatment of gastric cancer using combined treatments containing liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin) |
| IL291679A IL291679A (en) | 2016-11-02 | 2022-03-24 | Gastric cancer treatment using combined treatments containing liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL291679A IL291679A (en) | 2016-11-02 | 2022-03-24 | Gastric cancer treatment using combined treatments containing liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin) |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11071726B2 (OSRAM) |
| EP (1) | EP3535026A1 (OSRAM) |
| JP (2) | JP2019533684A (OSRAM) |
| KR (1) | KR20190077441A (OSRAM) |
| CN (1) | CN110402163A (OSRAM) |
| AU (1) | AU2017354903B2 (OSRAM) |
| BR (1) | BR112019007844A2 (OSRAM) |
| CA (1) | CA3040395A1 (OSRAM) |
| EA (1) | EA201990979A1 (OSRAM) |
| IL (2) | IL266187A (OSRAM) |
| MA (1) | MA46709A (OSRAM) |
| MX (1) | MX392408B (OSRAM) |
| MY (1) | MY202377A (OSRAM) |
| PH (1) | PH12019500892A1 (OSRAM) |
| RU (1) | RU2761953C2 (OSRAM) |
| SG (2) | SG11201903615WA (OSRAM) |
| TW (1) | TWI791467B (OSRAM) |
| WO (1) | WO2018083470A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2967961T3 (es) * | 2004-05-03 | 2024-05-06 | Ipsen Biopharm Ltd | Liposomas útiles en la administración de fármacos |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| WO2017031442A1 (en) | 2015-08-20 | 2017-02-23 | Merrimack Pharmaceuticals, Inc. | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
| JP2018528185A (ja) | 2015-08-21 | 2018-09-27 | イプセン バイオファーム リミティド | リポソーム型イリノテカン及びオキサリプラチンを含む組み合わせ療法を使用して転移性膵臓癌を治療するための方法 |
| SG10201912568PA (en) | 2015-10-16 | 2020-02-27 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| KR20190077441A (ko) | 2016-11-02 | 2019-07-03 | 입센 바이오팜 리미티드 | 리포솜성 이리노테칸, 옥살리플라틴, 5-플루오로우라실 (및 류코보린)을 포함하는 조합 요법을 사용하는 위암 치료 |
| CN116763734A (zh) | 2017-03-31 | 2023-09-19 | 富士胶片株式会社 | 脂质体组合物的制造方法 |
| JP7036919B2 (ja) | 2018-06-20 | 2022-03-15 | 富士フイルム株式会社 | 薬物を内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬 |
| JP7057434B2 (ja) * | 2018-10-01 | 2022-04-19 | 富士フイルム株式会社 | 薬物を内包するリポソーム組成物およびプラチナ製剤を含む組合せ医薬 |
| US12291570B2 (en) * | 2018-10-17 | 2025-05-06 | Biolinerx Ltd. | Treatment of metastatic pancreatic adenocarcinoma |
| EP3911353A1 (en) * | 2019-01-17 | 2021-11-24 | BioLineRx Ltd. | Specific combination therapy for treatment of pancreatic cancer |
| WO2020148744A1 (en) * | 2019-01-17 | 2020-07-23 | Biolinerx Ltd. | Combination therapy for treatment of pancreatic cancer |
| KR20210130765A (ko) * | 2019-02-22 | 2021-11-01 | 노보큐어 게엠베하 | Xelox, folfox 또는 이들의 각 구성 요소와 ttfield를 조합한 위암 치료 |
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2017
- 2017-11-01 KR KR1020197014970A patent/KR20190077441A/ko not_active Ceased
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- 2017-11-01 JP JP2019522381A patent/JP2019533684A/ja not_active Ceased
- 2017-11-01 MX MX2019004783A patent/MX392408B/es unknown
- 2017-11-01 TW TW106137766A patent/TWI791467B/zh active
- 2017-11-01 CN CN201780080584.XA patent/CN110402163A/zh active Pending
- 2017-11-01 SG SG11201903615WA patent/SG11201903615WA/en unknown
- 2017-11-01 EP EP17808557.7A patent/EP3535026A1/en not_active Ceased
- 2017-11-01 US US16/346,436 patent/US11071726B2/en not_active Expired - Fee Related
- 2017-11-01 MY MYPI2019002087A patent/MY202377A/en unknown
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- 2017-11-01 SG SG10201912338RA patent/SG10201912338RA/en unknown
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- 2017-11-01 BR BR112019007844A patent/BR112019007844A2/pt not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| IL291679A (en) | 2022-05-01 |
| MA46709A (fr) | 2019-09-11 |
| MY202377A (en) | 2024-04-24 |
| RU2761953C2 (ru) | 2021-12-14 |
| CN110402163A (zh) | 2019-11-01 |
| AU2017354903A1 (en) | 2019-05-02 |
| JP2019533684A (ja) | 2019-11-21 |
| PH12019500892A1 (en) | 2019-06-17 |
| SG10201912338RA (en) | 2020-02-27 |
| US20200030302A1 (en) | 2020-01-30 |
| AU2017354903B2 (en) | 2023-04-13 |
| MX392408B (es) | 2025-03-24 |
| CA3040395A1 (en) | 2018-05-11 |
| MX2019004783A (es) | 2019-08-12 |
| TW201825097A (zh) | 2018-07-16 |
| RU2019114952A (ru) | 2020-12-03 |
| US11071726B2 (en) | 2021-07-27 |
| RU2019114952A3 (OSRAM) | 2021-03-03 |
| TWI791467B (zh) | 2023-02-11 |
| SG11201903615WA (en) | 2019-05-30 |
| EP3535026A1 (en) | 2019-09-11 |
| JP2022171808A (ja) | 2022-11-11 |
| EA201990979A1 (ru) | 2019-09-30 |
| KR20190077441A (ko) | 2019-07-03 |
| WO2018083470A1 (en) | 2018-05-11 |
| BR112019007844A2 (pt) | 2019-07-16 |
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