IL264964B2 - Anti-CTLA4 and anti-PD1 bifunctional antibody, pharmaceutical preparation thereof and use thereof - Google Patents
Anti-CTLA4 and anti-PD1 bifunctional antibody, pharmaceutical preparation thereof and use thereofInfo
- Publication number
- IL264964B2 IL264964B2 IL264964A IL26496419A IL264964B2 IL 264964 B2 IL264964 B2 IL 264964B2 IL 264964 A IL264964 A IL 264964A IL 26496419 A IL26496419 A IL 26496419A IL 264964 B2 IL264964 B2 IL 264964B2
- Authority
- IL
- Israel
- Prior art keywords
- seq
- amino acid
- antigen
- variable region
- chain variable
- Prior art date
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Applications Claiming Priority (2)
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| CN201610705624.2A CN106967172B (zh) | 2016-08-23 | 2016-08-23 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| PCT/CN2017/098466 WO2018036473A1 (fr) | 2016-08-23 | 2017-08-22 | Anticorps bifonctionnel anti-ctla4 et anti-pd -1, composition pharmaceutique et utilisation associées |
Publications (3)
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| IL264964A IL264964A (fr) | 2019-04-30 |
| IL264964B1 IL264964B1 (en) | 2023-06-01 |
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| EP (1) | EP3511346A4 (fr) |
| JP (2) | JP7425604B2 (fr) |
| KR (1) | KR102503084B1 (fr) |
| CN (1) | CN106967172B (fr) |
| AU (1) | AU2017317124A1 (fr) |
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| NZ (1) | NZ751904A (fr) |
| SG (1) | SG11201901583WA (fr) |
| WO (1) | WO2018036473A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
| EP4257613A3 (fr) | 2016-06-14 | 2023-12-13 | Xencor, Inc. | Anticorps inhibiteurs de points de contrôle bispécifiques |
| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| WO2018035710A1 (fr) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anticorps anti-ctla4 |
| CN106977602B (zh) * | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| CN108866635B (zh) * | 2017-05-09 | 2021-11-26 | 安升（上海）医药科技有限公司 | 多特异性蛋白药物及其文库、以及制备方法和应用 |
| US11421029B2 (en) | 2017-09-01 | 2022-08-23 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Recombinant bispecific antibodies to PD-L1 and CTLA-4 |
| KR20200091382A (ko) * | 2017-11-02 | 2020-07-30 | 시스트이뮨, 인코포레이티드 | 이중특이성 항체 및 이의 제조 및 사용 방법 |
| WO2019179421A1 (fr) * | 2018-03-19 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Nouvelles molécules d'anticorps pd-1/ctla-4 bispécifiques |
| CN110407942B (zh) * | 2018-04-27 | 2022-02-22 | 苏州康宁杰瑞生物科技有限公司 | 针对kn044的单域抗体 |
| CN115991787A (zh) | 2018-06-05 | 2023-04-21 | 江苏康宁杰瑞生物制药有限公司 | 二聚体及其用途 |
| CN110684113A (zh) * | 2018-07-06 | 2020-01-14 | 复旦大学 | 一种抗PD-1抗原和抗c-Met抗原的双特异性抗体及其构建方法 |
| CN109762068A (zh) * | 2018-08-09 | 2019-05-17 | 源道隆（苏州）医学科技有限公司 | 一种可靶向ctla4和pd-1的单基因双特异性抗体及其应用 |
| CN109053895B (zh) * | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| WO2020057610A1 (fr) * | 2018-09-20 | 2020-03-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Nouveaux complexes polypeptidiques anti-ctla-4/pd-1 bispécifiques |
| WO2020057611A1 (fr) * | 2018-09-20 | 2020-03-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Nouveaux complexes polypeptidiques ctla-4/pd-1 bispécifiques |
| CN111763261B (zh) * | 2019-04-02 | 2022-08-09 | 杭州尚健生物技术有限公司 | 一种融合蛋白及其用途 |
| CN112175087B (zh) * | 2019-07-02 | 2022-05-13 | 深圳市迈加瑞生物技术有限公司 | 一种抗CD4和TGFβ的双特异性抗体、其药物组合及其用途 |
| EP3998286A4 (fr) * | 2019-07-11 | 2023-04-26 | Wuhan Yzy Biopharma Co., Ltd. | Anticorps bispécifique symétrique tétravalent |
| EP4008730A4 (fr) * | 2019-08-02 | 2023-09-06 | Akeso Pharmaceuticals, Inc. | Anticorps anti-ctla4-anti-pd-1 bispécifique et ses utilisations |
| US20220267444A1 (en) | 2019-08-02 | 2022-08-25 | CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. | Anti-pd-1 antibody and medical use thereof |
| CN112442126B (zh) * | 2019-09-04 | 2022-07-29 | 杭州济元基因科技有限公司 | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 |
| CN110563845A (zh) * | 2019-09-12 | 2019-12-13 | 滨州医学院 | 抗igsf9抗体、药物组合物及其应用 |
| BR112022010069A2 (pt) | 2019-11-25 | 2022-09-06 | Akeso Biopharma Inc | Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica |
| WO2021110106A1 (fr) * | 2019-12-04 | 2021-06-10 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | Protéine de fusion bispécifique pour le traitement de tumeurs |
| IL297432A (en) * | 2020-04-22 | 2022-12-01 | Akeso Biopharma Inc | Anti-cd73-anti-pd-1 bispecific antibody used |
| WO2021213523A1 (fr) * | 2020-04-24 | 2021-10-28 | 信达生物制药(苏州)有限公司 | Utilisations d'une combinaison d'anticorps anti-pd-1 et d'anticorps anti-ctla-4 dans la prévention ou le traitement du cancer |
| CN113577255B (zh) * | 2020-04-30 | 2023-09-08 | 中国科学院上海药物研究所 | 肿瘤纳米疫苗、其制备方法及用途 |
| CN111944760A (zh) * | 2020-08-14 | 2020-11-17 | 广东先康达生物科技有限公司 | 一种分泌双特异性抗体的免疫细胞及其应用 |
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| IL264964B1 (en) | 2023-06-01 |
| CN106967172B (zh) | 2019-01-08 |
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