IL261714B2 - Crispr/cas-related methods and compositions for treating beta hemoglobinopathies - Google Patents
Crispr/cas-related methods and compositions for treating beta hemoglobinopathiesInfo
- Publication number
- IL261714B2 IL261714B2 IL261714A IL26171418A IL261714B2 IL 261714 B2 IL261714 B2 IL 261714B2 IL 261714 A IL261714 A IL 261714A IL 26171418 A IL26171418 A IL 26171418A IL 261714 B2 IL261714 B2 IL 261714B2
- Authority
- IL
- Israel
- Prior art keywords
- domain
- certain embodiments
- cas9
- nucleotides
- molecule
- Prior art date
Links
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| US201662308190P | 2016-03-14 | 2016-03-14 | |
| US201762456615P | 2017-02-08 | 2017-02-08 | |
| PCT/US2017/022377 WO2017160890A1 (en) | 2016-03-14 | 2017-03-14 | Crispr/cas-related methods and compositions for treating beta hemoglobinopathies |
Publications (3)
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| IL261714A IL261714A (en) | 2018-10-31 |
| IL261714B1 IL261714B1 (en) | 2024-06-01 |
| IL261714B2 true IL261714B2 (en) | 2024-10-01 |
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| IL313038A IL313038A (en) | 2016-03-14 | 2017-03-14 | Methods and preparations related to CRISPR/CAS - for the treatment of diseases in the hemoglobin cell |
| IL261714A IL261714B2 (en) | 2016-03-14 | 2017-03-14 | Crispr/cas-related methods and compositions for treating beta hemoglobinopathies |
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| IL313038A IL313038A (en) | 2016-03-14 | 2017-03-14 | Methods and preparations related to CRISPR/CAS - for the treatment of diseases in the hemoglobin cell |
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| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3262173A2 (en) | 2015-02-23 | 2018-01-03 | Crispr Therapeutics AG | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| SG11201706766WA (en) | 2015-02-23 | 2017-09-28 | Crispr Therapeutics Ag | Materials and methods for treatment of hemoglobinopathies |
| JP7030522B2 (ja) | 2015-05-11 | 2022-03-07 | エディタス・メディシン、インコーポレイテッド | 幹細胞における遺伝子編集のための最適化ｃｒｉｓｐｒ／ｃａｓ９システムおよび方法 |
| KR102796744B1 (ko) | 2015-06-09 | 2025-04-15 | 에디타스 메디신, 인코포레이티드 | 이식의 개선을 위한 crispr/cas-관련 방법 및 조성물 |
| SG11201803173VA (en) | 2015-10-23 | 2018-05-30 | Harvard College | Nucleobase editors and uses thereof |
| EP3371306B8 (en) | 2015-11-04 | 2023-02-22 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| HRP20240842T1 (hr) * | 2016-11-02 | 2024-10-11 | Universität Basel | Imunološki uočljive varijante stanične površine za upotrebu u staničnoj terapiji |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
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| AU2017235333B2 (en) | 2023-08-24 |
| EP3430142A1 (en) | 2019-01-23 |
| CN117821458A (zh) | 2024-04-05 |
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