IL259404B2 - Media and fermentation methods for producing polysaccharides in bacterial cell culture - Google Patents

Media and fermentation methods for producing polysaccharides in bacterial cell culture

Info

Publication number
IL259404B2
IL259404B2 IL259404A IL25940418A IL259404B2 IL 259404 B2 IL259404 B2 IL 259404B2 IL 259404 A IL259404 A IL 259404A IL 25940418 A IL25940418 A IL 25940418A IL 259404 B2 IL259404 B2 IL 259404B2
Authority
IL
Israel
Prior art keywords
medium
concentration
polysaccharide
total
vvh
Prior art date
Application number
IL259404A
Other languages
English (en)
Hebrew (he)
Other versions
IL259404B1 (en
IL259404A (en
Inventor
Gururao Desai Sunil
Allen Hanson Michael
R Lasko Daniel
Ellis LOMBERK Scott
Arnold Lotvin Jason
Kaushikbhai PATEL-BROWN Sujata
Sun Weiqiang
Anthony Tomasello Peter
Patrick Kinross Jonathan
Original Assignee
Pfizer
Gururao Desai Sunil
Allen Hanson Michael
R Lasko Daniel
Ellis LOMBERK Scott
Arnold Lotvin Jason
Sujata Kaushikbhai Patel Brown
Sun Weiqiang
Anthony Tomasello Peter
Patrick Kinross Jonathan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Gururao Desai Sunil, Allen Hanson Michael, R Lasko Daniel, Ellis LOMBERK Scott, Arnold Lotvin Jason, Sujata Kaushikbhai Patel Brown, Sun Weiqiang, Anthony Tomasello Peter, Patrick Kinross Jonathan filed Critical Pfizer
Publication of IL259404A publication Critical patent/IL259404A/en
Publication of IL259404B1 publication Critical patent/IL259404B1/en
Publication of IL259404B2 publication Critical patent/IL259404B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL259404A 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture IL259404B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562256347P 2015-11-17 2015-11-17
US201662413051P 2016-10-26 2016-10-26
PCT/IB2016/056780 WO2017085602A1 (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

Publications (3)

Publication Number Publication Date
IL259404A IL259404A (en) 2018-07-31
IL259404B1 IL259404B1 (en) 2025-04-01
IL259404B2 true IL259404B2 (en) 2025-08-01

Family

ID=57394621

Family Applications (2)

Application Number Title Priority Date Filing Date
IL259404A IL259404B2 (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture
IL319202A IL319202A (en) 2015-11-17 2016-11-10 Substrates for fermentation methods to create polysaccharides in bacterial cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL319202A IL319202A (en) 2015-11-17 2016-11-10 Substrates for fermentation methods to create polysaccharides in bacterial cells

Country Status (13)

Country Link
US (3) US10947494B2 (enExample)
EP (1) EP3377613B1 (enExample)
JP (3) JP7311966B2 (enExample)
KR (1) KR102069988B1 (enExample)
CN (1) CN108473945A (enExample)
AU (1) AU2016357567B2 (enExample)
BR (1) BR112018008864A8 (enExample)
CA (2) CA3138763A1 (enExample)
HK (1) HK1259103A1 (enExample)
IL (2) IL259404B2 (enExample)
MX (2) MX385736B (enExample)
RU (2) RU2021135165A (enExample)
WO (1) WO2017085602A1 (enExample)

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AR086199A1 (es) 2011-04-22 2013-11-27 Wyeth Llc Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
SI2726600T1 (sl) 2011-07-01 2017-07-31 Amgen Inc. Sesalska celična kultura
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
CN109890413B (zh) 2016-09-02 2024-04-16 赛诺菲巴斯德股份有限公司 脑膜炎奈瑟氏菌疫苗
WO2018144439A1 (en) 2017-01-31 2018-08-09 Merck Sharp & Dohme Corp. Methods for making polysaccharide-protein conjugates
JP7680185B2 (ja) 2017-02-24 2025-05-20 メルク・シャープ・アンド・ドーム・エルエルシー 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強
CN111065387B (zh) 2017-09-07 2023-08-25 默沙东有限责任公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
US11395849B2 (en) 2017-09-07 2022-07-26 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
EP3720483B1 (en) 2017-12-06 2025-11-19 Merck Sharp & Dohme LLC Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
WO2019212842A1 (en) 2018-04-30 2019-11-07 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres
WO2019212846A1 (en) 2018-04-30 2019-11-07 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
JP7397000B2 (ja) 2018-04-30 2023-12-12 メルク・シャープ・アンド・ドーム・エルエルシー 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法
KR102609289B1 (ko) * 2018-12-06 2023-12-01 인벤트프라이즈 인크. 비-동물성 배지에서의 박테리아 증식
WO2020123524A1 (en) * 2018-12-11 2020-06-18 Erbi Biosystems, Inc. Methods of manufacturing cell based products using small volume perfusion processes
EP3897705A2 (en) 2018-12-19 2021-10-27 Merck Sharp & Dohme Corp. Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
CN111254103B (zh) * 2019-11-19 2023-06-02 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
JP2023522059A (ja) * 2020-04-20 2023-05-26 エボニック オペレーションズ ゲーエムベーハー Ｃｙｓ－ペプチドを含む組成物
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN114015622A (zh) * 2021-12-14 2022-02-08 塔里木大学 无乳链球菌培养基及其制备方法
WO2023131588A1 (en) * 2022-01-05 2023-07-13 Nordmark Pharma Gmbh Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases
CN114181872B (zh) * 2022-01-07 2023-11-24 北京大北农科技集团股份有限公司 一种屎肠球菌高密度发酵培养方法
KR102864280B1 (ko) * 2022-12-27 2025-09-26 (주)진성유니텍 포도상구균 증균을 위한 최소배지 및 이를 이용한 포도상구균 증균방법
KR102866798B1 (ko) * 2022-12-27 2025-10-01 (주)진성유니텍 살모넬라균 증균을 위한 최소배지 및 이를 이용한 살모넬라균 증균방법
CN117821342B (zh) * 2024-02-29 2024-06-04 北京民海生物科技有限公司 一种14型肺炎链球菌的发酵方法
KR102894728B1 (ko) 2024-11-27 2025-12-08 한국콜마주식회사 피지 생성 억제 효능, 모공 개선 효능 및 피부 장벽 강화 효능이 우수한 흑효모 발효물 및 이의 제조방법

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WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
WO2011151841A1 (en) * 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae

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US7491517B2 (en) * 2006-07-19 2009-02-17 Jeeri R Reddy Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135
MX2009004974A (es) 2006-11-08 2009-05-20 Wyeth Corp Medios diseñado racionalmente para cultivo celular.
GB0818453D0 (en) * 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
WO2012155295A1 (zh) * 2011-05-17 2012-11-22 中国食品发酵工业研究院 一种工业化生产玉米降压活性肽的方法
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EP2647715A1 (en) * 2012-04-03 2013-10-09 Nomad Bioscience GmbH Agrobacterium for transient transfection of whole plants
GB201211256D0 (en) * 2012-06-25 2012-08-08 Glaxosmithkline Biolog Sa Fermentation process
NZ708523A (en) * 2012-11-21 2018-09-28 Serum Institute Of India Pvt Ltd Production of high yields of bacterial polysaccharides

Patent Citations (2)

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WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
WO2011151841A1 (en) * 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae

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MARTHOS BRUNO VITORIO ET AL,, CAPSULAR POLYSACCHARIDE PRODUCTION BYSTREPTOCOCCUS PNEUMONIAESEROTYPE 1: FROM STRAIN SELECTION TO FED-BATCH CULTIVATION, 23 August 2015 (2015-08-23) *

Also Published As

Publication number Publication date
US10947494B2 (en) 2021-03-16
HK1259103A1 (zh) 2019-11-22
RU2021135165A (ru) 2021-12-29
MX385736B (es) 2025-03-18
KR20180073699A (ko) 2018-07-02
IL259404B1 (en) 2025-04-01
US20190292513A1 (en) 2019-09-26
JP2018533366A (ja) 2018-11-15
JP7311966B2 (ja) 2023-07-20
CA3005308A1 (en) 2017-05-26
MX2018006063A (es) 2018-09-17
JP7814142B2 (ja) 2026-02-16
JP2024037949A (ja) 2024-03-19
RU2018118035A (ru) 2019-12-18
CA3138763A1 (en) 2017-05-26
CN108473945A (zh) 2018-08-31
RU2761633C2 (ru) 2021-12-13
EP3377613A1 (en) 2018-09-26
IL319202A (en) 2025-04-01
US20210180008A1 (en) 2021-06-17
BR112018008864A2 (pt) 2018-11-06
WO2017085602A1 (en) 2017-05-26
KR102069988B1 (ko) 2020-01-23
AU2016357567B2 (en) 2020-05-07
IL259404A (en) 2018-07-31
EP3377613B1 (en) 2026-07-15
RU2018118035A3 (enExample) 2019-12-18
JP2022017529A (ja) 2022-01-25
MX2021010518A (es) 2021-10-01
CA3005308C (en) 2022-01-04
AU2016357567A1 (en) 2018-05-17
BR112018008864A8 (pt) 2019-02-26
US20260008994A1 (en) 2026-01-08

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