IL256432A - 6-amino-quinoline-3-carbonitrils as cot modulators - Google Patents
6-amino-quinoline-3-carbonitrils as cot modulatorsInfo
- Publication number
- IL256432A IL256432A IL256432A IL25643217A IL256432A IL 256432 A IL256432 A IL 256432A IL 256432 A IL256432 A IL 256432A IL 25643217 A IL25643217 A IL 25643217A IL 256432 A IL256432 A IL 256432A
- Authority
- IL
- Israel
- Prior art keywords
- carbonitrils
- quinoline
- amino
- cot
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562189155P | 2015-07-06 | 2015-07-06 | |
US201562269061P | 2015-12-17 | 2015-12-17 | |
PCT/US2016/040552 WO2017007694A1 (en) | 2015-07-06 | 2016-06-30 | 6-amino-quinoline-3-carbonitrils as cot modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
IL256432A true IL256432A (en) | 2018-02-28 |
Family
ID=56497863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL256432A IL256432A (en) | 2015-07-06 | 2017-12-20 | 6-amino-quinoline-3-carbonitrils as cot modulators |
Country Status (19)
Country | Link |
---|---|
US (2) | US9815818B2 (ja) |
EP (1) | EP3319955B1 (ja) |
JP (1) | JP6525362B2 (ja) |
KR (2) | KR102082331B1 (ja) |
CN (1) | CN108026067B (ja) |
AU (1) | AU2016289817B2 (ja) |
BR (1) | BR112018000187A2 (ja) |
CA (1) | CA2991572A1 (ja) |
EA (1) | EA201792612A1 (ja) |
ES (1) | ES2849953T3 (ja) |
HK (1) | HK1252613A1 (ja) |
IL (1) | IL256432A (ja) |
MX (1) | MX2017017124A (ja) |
NZ (1) | NZ738538A (ja) |
PL (1) | PL3319955T3 (ja) |
PT (1) | PT3319955T (ja) |
SI (1) | SI3319955T1 (ja) |
TW (1) | TWI711611B (ja) |
WO (1) | WO2017007694A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
CN108026067B (zh) | 2015-07-06 | 2021-01-12 | 吉利德科学公司 | 作为cot调节剂的6-氨基-喹啉-3-腈 |
KR102443575B1 (ko) | 2015-07-06 | 2022-09-16 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
AU2017289158C1 (en) | 2016-06-30 | 2020-07-23 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as Cot modulators and methods of use thereof |
CN108329306A (zh) * | 2017-07-09 | 2018-07-27 | 曹艳 | 一种用于治疗艾滋病药物的制备方法 |
JPWO2019065516A1 (ja) * | 2017-09-26 | 2020-09-10 | 日本曹達株式会社 | キノリン化合物および農園芸用殺菌剤 |
TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
JP2023520650A (ja) | 2020-03-30 | 2023-05-18 | ギリアード サイエンシーズ, インコーポレイテッド | (S)-6-(((1-(ビシクロ[1.1.1]ペンタン-1-イル)-1H-1,2,3-トリアゾール-4-イル)2-メチル-1-オキソ-1,2-ジヒドロイソキノリン-5-イル)メチル)))アミノ)8-クロロ-(ネオペンチルアミノ)キノリン-3-カルボニトリルCot阻害剤化合物の固体形態 |
KR20220160645A (ko) | 2020-04-02 | 2022-12-06 | 길리애드 사이언시즈, 인코포레이티드 | Cot 저해제 화합물의 제조 방법 |
TW202304435A (zh) | 2021-06-04 | 2023-02-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
CN115433096B (zh) * | 2022-09-16 | 2024-02-06 | 浙江省农业科学院 | 一种抗臭氧剂的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
AU2004267061A1 (en) | 2003-08-19 | 2005-03-03 | Wyeth Holdings Corporation | Process for the preparation of 4-amino-3-quinolinecarbonitriles |
JP2008540656A (ja) * | 2005-05-18 | 2008-11-20 | ワイス | Tpl2キナーゼの3−シアノキノリン阻害物質ならびにそれを製造および使用する方法 |
JP2008540667A (ja) | 2005-05-18 | 2008-11-20 | ワイス | Tpl2キナーゼの4,6−ジアミノ−[1,7]ナフチリジン−3−カルボニトリル阻害物質ならびにそれを製造および使用する方法 |
MX2008012482A (es) | 2006-03-31 | 2008-10-10 | Abbott Lab | Compuestos de indazol. |
US7741354B2 (en) * | 2006-11-09 | 2010-06-22 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
ES2714875T3 (es) | 2010-03-09 | 2019-05-30 | Dana Farber Cancer Inst Inc | Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer |
IN2015DN03795A (ja) * | 2012-10-24 | 2015-10-02 | Inserm Inst Nat De La Santé Et De La Rech Médicale | |
CN108026067B (zh) | 2015-07-06 | 2021-01-12 | 吉利德科学公司 | 作为cot调节剂的6-氨基-喹啉-3-腈 |
KR102443575B1 (ko) | 2015-07-06 | 2022-09-16 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
AU2017289158C1 (en) | 2016-06-30 | 2020-07-23 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as Cot modulators and methods of use thereof |
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2016
- 2016-06-30 CN CN201680051571.5A patent/CN108026067B/zh active Active
- 2016-06-30 AU AU2016289817A patent/AU2016289817B2/en active Active
- 2016-06-30 WO PCT/US2016/040552 patent/WO2017007694A1/en active Application Filing
- 2016-06-30 SI SI201631016T patent/SI3319955T1/sl unknown
- 2016-06-30 EA EA201792612A patent/EA201792612A1/ru unknown
- 2016-06-30 KR KR1020187003220A patent/KR102082331B1/ko active IP Right Grant
- 2016-06-30 MX MX2017017124A patent/MX2017017124A/es unknown
- 2016-06-30 KR KR1020207005179A patent/KR20200022527A/ko active Application Filing
- 2016-06-30 JP JP2018500579A patent/JP6525362B2/ja active Active
- 2016-06-30 NZ NZ738538A patent/NZ738538A/en not_active IP Right Cessation
- 2016-06-30 PL PL16741446T patent/PL3319955T3/pl unknown
- 2016-06-30 BR BR112018000187A patent/BR112018000187A2/pt not_active IP Right Cessation
- 2016-06-30 ES ES16741446T patent/ES2849953T3/es active Active
- 2016-06-30 US US15/199,779 patent/US9815818B2/en active Active
- 2016-06-30 PT PT167414465T patent/PT3319955T/pt unknown
- 2016-06-30 CA CA2991572A patent/CA2991572A1/en active Pending
- 2016-06-30 EP EP16741446.5A patent/EP3319955B1/en active Active
- 2016-07-05 TW TW105121276A patent/TWI711611B/zh active
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2017
- 2017-09-07 US US15/697,755 patent/US10316017B2/en active Active
- 2017-12-20 IL IL256432A patent/IL256432A/en unknown
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2018
- 2018-09-17 HK HK18111913.1A patent/HK1252613A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20170362201A1 (en) | 2017-12-21 |
KR102082331B1 (ko) | 2020-02-27 |
JP6525362B2 (ja) | 2019-06-05 |
EA201792612A1 (ru) | 2018-07-31 |
AU2016289817A1 (en) | 2018-01-18 |
NZ738538A (en) | 2019-06-28 |
CN108026067B (zh) | 2021-01-12 |
US10316017B2 (en) | 2019-06-11 |
EP3319955B1 (en) | 2020-11-25 |
JP2018520160A (ja) | 2018-07-26 |
US9815818B2 (en) | 2017-11-14 |
KR20200022527A (ko) | 2020-03-03 |
WO2017007694A1 (en) | 2017-01-12 |
US20170008873A1 (en) | 2017-01-12 |
PL3319955T3 (pl) | 2021-05-04 |
EP3319955A1 (en) | 2018-05-16 |
BR112018000187A2 (pt) | 2018-09-04 |
AU2016289817B2 (en) | 2019-01-31 |
MX2017017124A (es) | 2018-03-09 |
CN108026067A (zh) | 2018-05-11 |
TWI711611B (zh) | 2020-12-01 |
KR20180022981A (ko) | 2018-03-06 |
HK1252613A1 (zh) | 2019-05-31 |
PT3319955T (pt) | 2021-01-05 |
SI3319955T1 (sl) | 2021-01-29 |
TW201713643A (zh) | 2017-04-16 |
CA2991572A1 (en) | 2017-01-12 |
ES2849953T3 (es) | 2021-08-24 |
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