IL255516B - Oxabicycloheptane prodrugs - Google Patents

Oxabicycloheptane prodrugs

Info

Publication number
IL255516B
IL255516B IL255516A IL25551617A IL255516B IL 255516 B IL255516 B IL 255516B IL 255516 A IL255516 A IL 255516A IL 25551617 A IL25551617 A IL 25551617A IL 255516 B IL255516 B IL 255516B
Authority
IL
Israel
Prior art keywords
oxabicycloheptane
prodrugs
oxabicycloheptane prodrugs
Prior art date
Application number
IL255516A
Other languages
English (en)
Hebrew (he)
Other versions
IL255516A (en
Original Assignee
Lixte Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lixte Biotechnology Inc filed Critical Lixte Biotechnology Inc
Publication of IL255516A publication Critical patent/IL255516A/en
Publication of IL255516B publication Critical patent/IL255516B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL255516A 2015-05-15 2017-11-08 Oxabicycloheptane prodrugs IL255516B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562162501P 2015-05-15 2015-05-15
PCT/US2016/032123 WO2016186963A1 (en) 2015-05-15 2016-05-12 Oxabicycloheptane prodrugs

Publications (2)

Publication Number Publication Date
IL255516A IL255516A (en) 2018-01-31
IL255516B true IL255516B (en) 2020-02-27

Family

ID=57276640

Family Applications (2)

Application Number Title Priority Date Filing Date
IL255516A IL255516B (en) 2015-05-15 2017-11-08 Oxabicycloheptane prodrugs
IL272027A IL272027B (en) 2015-05-15 2020-01-14 Endothal prodrugs for use in treating cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL272027A IL272027B (en) 2015-05-15 2020-01-14 Endothal prodrugs for use in treating cancer

Country Status (12)

Country Link
US (5) US9988394B2 (cg-RX-API-DMAC7.html)
EP (2) EP3294287B1 (cg-RX-API-DMAC7.html)
JP (3) JP7187023B6 (cg-RX-API-DMAC7.html)
CN (2) CN107708686B (cg-RX-API-DMAC7.html)
AU (1) AU2016263079B2 (cg-RX-API-DMAC7.html)
DK (1) DK3294287T3 (cg-RX-API-DMAC7.html)
ES (2) ES2795950T3 (cg-RX-API-DMAC7.html)
HU (1) HUE050177T2 (cg-RX-API-DMAC7.html)
IL (2) IL255516B (cg-RX-API-DMAC7.html)
MX (2) MX386975B (cg-RX-API-DMAC7.html)
TW (2) TWI693226B (cg-RX-API-DMAC7.html)
WO (1) WO2016186963A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2877167A1 (en) 2012-06-29 2014-01-03 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes
JP2016516772A (ja) 2013-04-09 2016-06-09 リクスト・バイオテクノロジー,インコーポレイテッド オキサシクロヘプタン及びオキサビシクロヘプテンの配合物
JP6453441B2 (ja) 2014-07-24 2019-01-16 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 骨髄異形成症候群を治療するためのタンパク質ホスファターゼ2a阻害剤
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
MX382044B (es) 2015-02-19 2025-03-13 Lixte Biotechnology Inc Oxabicicloheptanos y oxabicicloheptenos para el tratamiento de trastornos depresivos y de estrés.
EP3294287B1 (en) 2015-05-15 2020-04-08 Lixte Biotechnology, Inc. Oxabicycloheptane prodrugs
BR112019011627A2 (pt) 2016-12-08 2019-11-12 Lixte Biotechnology Inc oxabiciclo-heptanos para modulação da resposta imunológica

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AU2001243253A1 (en) 2000-02-24 2001-09-03 Biocryst Pharmaceuticals, Inc. Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
EP1463713A1 (en) 2001-11-23 2004-10-06 Eli Lilly And Company Prodrugs of excitatory amino acids
WO2004087153A2 (en) * 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
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US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
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JP5693850B2 (ja) 2007-02-06 2015-04-01 リクスト・バイオテクノロジー,インコーポレイテッド オキサビシクロヘプタンおよびオキサビシクロヘプテン、それらの製造および使用
EP2185173A4 (en) 2007-08-03 2011-01-12 Lixte Biotechnology Inc USE OF PHOSPHATASES FOR THE TREATMENT OF NEUROBLASTOMES AND MEDULLOGASTOMES
CN101854804B (zh) 2007-10-01 2014-07-23 利克斯特生物技术公司 Hdac抑制剂
WO2010014220A1 (en) 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
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JP2016538281A (ja) * 2013-11-15 2016-12-08 リクスト・バイオテクノロジー,インコーポレイテッド 血液脳関門を通過するタンパク質ホスファターゼ阻害剤
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JP6453441B2 (ja) 2014-07-24 2019-01-16 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 骨髄異形成症候群を治療するためのタンパク質ホスファターゼ2a阻害剤
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MX382044B (es) 2015-02-19 2025-03-13 Lixte Biotechnology Inc Oxabicicloheptanos y oxabicicloheptenos para el tratamiento de trastornos depresivos y de estrés.
EP3294287B1 (en) 2015-05-15 2020-04-08 Lixte Biotechnology, Inc. Oxabicycloheptane prodrugs
WO2017132445A1 (en) 2016-01-27 2017-08-03 Lixte Biotechnology, Inc. Clincal regimen for treating myelodysplastic syndrome with phosphatase inhibitor
BR112019011627A2 (pt) 2016-12-08 2019-11-12 Lixte Biotechnology Inc oxabiciclo-heptanos para modulação da resposta imunológica
US20210275521A1 (en) 2017-12-05 2021-09-09 Lixte Biotechnology, Inc. Oxabicycloheptanes for treatment of secondary acute myeloid leukemia

Also Published As

Publication number Publication date
US20200325151A1 (en) 2020-10-15
EP3294287A4 (en) 2018-10-31
US10364252B2 (en) 2019-07-30
WO2016186963A1 (en) 2016-11-24
MX2017014549A (es) 2018-09-11
JP2020180130A (ja) 2020-11-05
JP7187023B6 (ja) 2023-01-05
CN107708686A (zh) 2018-02-16
EP3294287A1 (en) 2018-03-21
ES2985668T3 (es) 2024-11-06
DK3294287T3 (da) 2020-06-08
US9988394B2 (en) 2018-06-05
US11866444B2 (en) 2024-01-09
TW201713667A (zh) 2017-04-16
TWI757720B (zh) 2022-03-11
US20190359627A1 (en) 2019-11-28
JP7187023B2 (ja) 2022-12-12
CA2986104A1 (en) 2016-11-24
HK1247576A1 (en) 2018-09-28
US20220235066A1 (en) 2022-07-28
EP3736275B1 (en) 2024-07-03
CN113150030A (zh) 2021-07-23
IL255516A (en) 2018-01-31
US20160333024A1 (en) 2016-11-17
TW202043237A (zh) 2020-12-01
CN107708686B (zh) 2021-02-19
EP3294287B1 (en) 2020-04-08
IL272027B (en) 2021-10-31
US20180244690A1 (en) 2018-08-30
MX2021012440A (es) 2022-06-28
US11236102B2 (en) 2022-02-01
IL272027A (en) 2020-02-27
TWI693226B (zh) 2020-05-11
AU2016263079B2 (en) 2019-08-15
EP3736275A1 (en) 2020-11-11
JP2023100645A (ja) 2023-07-19
MX393461B (es) 2025-03-24
AU2016263079A1 (en) 2017-12-07
EP3736275C0 (en) 2024-07-03
ES2795950T3 (es) 2020-11-25
US10618908B2 (en) 2020-04-14
MX386975B (es) 2025-03-19
HUE050177T2 (hu) 2020-11-30
JP2018515614A (ja) 2018-06-14

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