IL254951B - Humanized influenza monoclonal antibodies and methods of use thereof - Google Patents

Humanized influenza monoclonal antibodies and methods of use thereof

Info

Publication number
IL254951B
IL254951B IL254951A IL25495117A IL254951B IL 254951 B IL254951 B IL 254951B IL 254951 A IL254951 A IL 254951A IL 25495117 A IL25495117 A IL 25495117A IL 254951 B IL254951 B IL 254951B
Authority
IL
Israel
Prior art keywords
methods
monoclonal antibodies
human origin
influenza monoclonal
influenza
Prior art date
Application number
IL254951A
Other languages
English (en)
Hebrew (he)
Other versions
IL254951A0 (en
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of IL254951A0 publication Critical patent/IL254951A0/en
Publication of IL254951B publication Critical patent/IL254951B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL254951A 2015-04-08 2017-10-09 Humanized influenza monoclonal antibodies and methods of use thereof IL254951B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562144729P 2015-04-08 2015-04-08
PCT/US2016/026800 WO2016164835A1 (en) 2015-04-08 2016-04-08 Humanized influenza monoclonal antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
IL254951A0 IL254951A0 (en) 2017-12-31
IL254951B true IL254951B (en) 2021-09-30

Family

ID=55754481

Family Applications (2)

Application Number Title Priority Date Filing Date
IL254951A IL254951B (en) 2015-04-08 2017-10-09 Humanized influenza monoclonal antibodies and methods of use thereof
IL286208A IL286208A (en) 2015-04-08 2021-09-09 Humanized influenza monoclonal antibodies and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL286208A IL286208A (en) 2015-04-08 2021-09-09 Humanized influenza monoclonal antibodies and methods of use thereof

Country Status (9)

Country Link
US (2) US11135282B2 (https=)
EP (1) EP3280730B1 (https=)
JP (3) JP6960856B2 (https=)
KR (1) KR102668588B1 (https=)
CN (1) CN107750253B (https=)
AU (2) AU2016246065B2 (https=)
CA (1) CA2981969C (https=)
IL (2) IL254951B (https=)
WO (1) WO2016164835A1 (https=)

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US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
EP4043489A1 (en) * 2014-03-19 2022-08-17 Dana-Farber Cancer Institute, Inc. Immunogenetic restriction on elicitation of antibodies
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
CN120795163A (zh) 2016-10-14 2025-10-17 丹娜法伯癌症研究所公司 模块化四聚体双特异性抗体平台
US11780907B2 (en) 2018-01-26 2023-10-10 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
AU2019235900B2 (en) 2018-03-14 2025-12-11 Dana-Farber Cancer Institute, Inc. Engineered cells, T cell immune modulating antibodies and methods for using the same
US20200064353A1 (en) 2018-08-13 2020-02-27 Regeneron Pharmaceuticals, Inc. Therapeutic Protein Selection in Simulated In Vivo Conditions
CN109448781B (zh) * 2018-11-06 2021-09-14 云南大学 一种流感病毒抗原变化的预测方法
CN111423507B (zh) * 2019-01-10 2022-04-15 中国科学院分子细胞科学卓越创新中心 广谱性中和流感病毒的全人抗体
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2021119467A1 (en) * 2019-12-11 2021-06-17 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2023081471A1 (en) 2021-11-05 2023-05-11 Dana-Farber Cancer Institute, Inc. Human broadly crossreactive influenza monoclonal antibodies and methods of use thereof
CN114366809B (zh) * 2022-01-12 2024-07-23 广州瑞贝斯药业有限公司 一种铝纳米晶递送系统及其结合疫苗抗原分子自组装颗粒佐剂疫苗

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Also Published As

Publication number Publication date
AU2021225240A1 (en) 2021-09-30
WO2016164835A1 (en) 2016-10-13
EP3280730A1 (en) 2018-02-14
KR20170133507A (ko) 2017-12-05
JP2021121204A (ja) 2021-08-26
CA2981969C (en) 2023-12-05
CN107750253A (zh) 2018-03-02
JP2018518940A (ja) 2018-07-19
US12076390B2 (en) 2024-09-03
US11135282B2 (en) 2021-10-05
US20220054624A1 (en) 2022-02-24
AU2016246065A1 (en) 2017-10-26
IL286208A (en) 2021-10-31
AU2016246065B2 (en) 2021-06-03
JP6960856B2 (ja) 2021-11-05
CN107750253B (zh) 2022-10-04
CA2981969A1 (en) 2016-10-13
JP2023130499A (ja) 2023-09-20
EP3280730C0 (en) 2024-01-03
EP3280730B1 (en) 2024-01-03
IL254951A0 (en) 2017-12-31
US20180099040A1 (en) 2018-04-12
KR102668588B1 (ko) 2024-05-22

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