IL251503A0 - Single-chain biphasic insulin analogs, preparations containing them and their uses - Google Patents

Single-chain biphasic insulin analogs, preparations containing them and their uses

Info

Publication number
IL251503A0
IL251503A0 IL251503A IL25150317A IL251503A0 IL 251503 A0 IL251503 A0 IL 251503A0 IL 251503 A IL251503 A IL 251503A IL 25150317 A IL25150317 A IL 25150317A IL 251503 A0 IL251503 A0 IL 251503A0
Authority
IL
Israel
Prior art keywords
compositions
same
insulin analogues
chain insulin
biphasic
Prior art date
Application number
IL251503A
Other languages
English (en)
Hebrew (he)
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of IL251503A0 publication Critical patent/IL251503A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL251503A 2014-10-06 2017-04-02 Single-chain biphasic insulin analogs, preparations containing them and their uses IL251503A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (1)

Publication Number Publication Date
IL251503A0 true IL251503A0 (en) 2017-05-29

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
IL251503A IL251503A0 (en) 2014-10-06 2017-04-02 Single-chain biphasic insulin analogs, preparations containing them and their uses

Country Status (10)

Country Link
US (2) US10392429B2 (cg-RX-API-DMAC7.html)
EP (1) EP3204410B1 (cg-RX-API-DMAC7.html)
JP (1) JP6829928B2 (cg-RX-API-DMAC7.html)
KR (1) KR102569743B1 (cg-RX-API-DMAC7.html)
CN (1) CN107108716A (cg-RX-API-DMAC7.html)
AU (1) AU2015328222B9 (cg-RX-API-DMAC7.html)
BR (1) BR112017004544A2 (cg-RX-API-DMAC7.html)
CA (1) CA2961037A1 (cg-RX-API-DMAC7.html)
IL (1) IL251503A0 (cg-RX-API-DMAC7.html)
WO (1) WO2016057529A2 (cg-RX-API-DMAC7.html)

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CN106102763A (zh) 2014-01-13 2016-11-09 塞尔玛琳糖尿病有限责任公司 速效胰岛素制剂和药物递送系统
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
AU2017361524B2 (en) * 2016-11-21 2022-06-02 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
SI4186920T1 (sl) * 2018-06-29 2024-05-31 Akston Biosciences Corporation Ultra dolgo delujoči inzulin-FC fuzijski proteini in postopki uporabe
WO2020061554A1 (en) * 2018-09-21 2020-03-26 Case Western Reserve University Site 2 single-chain insulin analogues
US12077568B2 (en) 2018-10-01 2024-09-03 University Of Houston System Engineered active single-polypeptide chain insulin analogs
WO2020106748A1 (en) * 2018-11-19 2020-05-28 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
US20220235111A1 (en) * 2019-05-17 2022-07-28 Case Western Reserve University Variant Single-Chain Insulin Analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
EP4007594A4 (en) * 2019-08-02 2023-08-09 Case Western Reserve University Premixed ultra-stable single-chain insulin analogue formulations
CN115916243A (zh) * 2020-03-02 2023-04-04 塞尔玛琳公司 含有速效胰岛素类似物的组合物
WO2022125587A1 (en) * 2020-12-07 2022-06-16 Case Western Reserve University Acylated single-chain insulin analogues
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
EP4405384A1 (en) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin fusion protein

Family Cites Families (45)

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Publication number Priority date Publication date Assignee Title
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
EP0425482B1 (en) 1988-07-20 1993-08-18 Novo Nordisk A/S Human insulin analogs and preparations containing them
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DE3936876A1 (de) 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK158390D0 (da) 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
US5422339A (en) 1991-03-19 1995-06-06 Joslin Diabetes Center, Inc. Peptides having insulin autoantibody but not insulin receptor binding capacity
CZ342492A3 (en) 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
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WO2003053460A1 (en) 2001-12-19 2003-07-03 Eli Lilly And Company Crystalline compositions for controlling blood glucose
BR0215029A (pt) 2001-12-20 2005-12-20 Lilly Co Eli Molécula de insulina, uso da mesma, composição, uso desta, microcristal, processo para prepará-lo, uso deste, e, métodos para preparar uma molécula de insulina, para tratar hiperglicemia, e para tratar diabetes mellitus
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EP1523326A4 (en) 2002-05-06 2009-09-09 Univ Jefferson INSULIN-ASSOCIATED PEPTIDES FOR IMPROVING BRAIN EFFECT
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US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
CA2722168A1 (en) * 2008-04-22 2009-10-29 Case Western Reserve University Isoform-specific insulin analogues
WO2009133099A2 (en) * 2008-04-28 2009-11-05 Novo Nordisk A/S Insulin precursors for diabetes treatment
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WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
CA2783763A1 (en) 2009-12-11 2011-06-16 Case Western Reserve University Insulin analogues with chlorinated amino acids
CA2790495A1 (en) 2010-02-22 2011-08-25 Case Western Reserve University Long-acting insulin analogue preparations in soluble and crystalline forms
AU2011268327B2 (en) * 2010-06-16 2016-02-25 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
CN105008395B (zh) 2012-11-05 2020-12-29 卡斯西部储备大学 长效单链胰岛素类似物

Also Published As

Publication number Publication date
KR102569743B1 (ko) 2023-08-23
AU2015328222B2 (en) 2020-08-20
US20190375814A1 (en) 2019-12-12
CN107108716A (zh) 2017-08-29
JP6829928B2 (ja) 2021-02-17
EP3204410A4 (en) 2018-03-07
AU2015328222A1 (en) 2017-03-16
US20180265560A1 (en) 2018-09-20
WO2016057529A3 (en) 2016-11-03
US10392429B2 (en) 2019-08-27
BR112017004544A2 (pt) 2018-01-23
WO2016057529A2 (en) 2016-04-14
KR20170064533A (ko) 2017-06-09
EP3204410A2 (en) 2017-08-16
EP3204410B1 (en) 2021-01-20
AU2015328222B9 (en) 2020-12-24
CA2961037A1 (en) 2016-04-14
US11142560B2 (en) 2021-10-12
JP2017536337A (ja) 2017-12-07

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