IL251068A0 - Genotype-specific dosage regimens (val66met (snp rs6265) and methods for treating depression - Google Patents

Genotype-specific dosage regimens (val66met (snp rs6265) and methods for treating depression

Info

Publication number
IL251068A0
IL251068A0 IL251068A IL25106817A IL251068A0 IL 251068 A0 IL251068 A0 IL 251068A0 IL 251068 A IL251068 A IL 251068A IL 25106817 A IL25106817 A IL 25106817A IL 251068 A0 IL251068 A0 IL 251068A0
Authority
IL
Israel
Prior art keywords
val66met
snp
depression
treatment
methods
Prior art date
Application number
IL251068A
Other languages
English (en)
Hebrew (he)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL251068(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL251068A0 publication Critical patent/IL251068A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL251068A 2014-09-15 2017-03-09 Genotype-specific dosage regimens (val66met (snp rs6265) and methods for treating depression IL251068A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462050439P 2014-09-15 2014-09-15
PCT/US2015/049961 WO2016044150A1 (en) 2014-09-15 2015-09-14 VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION

Publications (1)

Publication Number Publication Date
IL251068A0 true IL251068A0 (en) 2017-04-30

Family

ID=54200096

Family Applications (2)

Application Number Title Priority Date Filing Date
IL251068A IL251068A0 (en) 2014-09-15 2017-03-09 Genotype-specific dosage regimens (val66met (snp rs6265) and methods for treating depression
IL279119A IL279119A (en) 2014-09-15 2020-12-01 VAL66MET genotype-specific dosage regimens (SNP rs6265) and methods for treating depression

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL279119A IL279119A (en) 2014-09-15 2020-12-01 VAL66MET genotype-specific dosage regimens (SNP rs6265) and methods for treating depression

Country Status (11)

Country Link
US (6) US20160074340A1 (OSRAM)
EP (2) EP3193853A1 (OSRAM)
JP (2) JP2017528483A (OSRAM)
KR (1) KR20170054470A (OSRAM)
CN (1) CN107208133A (OSRAM)
AU (1) AU2015318123A1 (OSRAM)
CA (1) CA2961208A1 (OSRAM)
IL (2) IL251068A0 (OSRAM)
MA (1) MA40620A (OSRAM)
MX (1) MX2017003366A (OSRAM)
WO (1) WO2016044150A1 (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2755809T3 (es) 2013-03-15 2020-04-23 Janssen Pharmaceutica Nv Composición farmacéutica de hidrocloruro de S-ketamina
WO2016044150A1 (en) 2014-09-15 2016-03-24 Janssen Pharmaceutica Nv VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION
US20160338977A1 (en) * 2015-05-20 2016-11-24 Janssen Pharmaceutica Nv Methods and kits for treating depression
US20190078161A1 (en) * 2016-03-18 2019-03-14 Tekada Pharmaceutical Company Limited Method for identifying clinical trial responders from a placebo group in major depression
AU2017351437B2 (en) * 2016-10-27 2022-01-27 National University Corporation Chiba University Application of (S)-norketamine and salt thereof as pharmaceutical
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
BR112020012473A2 (pt) * 2017-12-22 2020-11-24 Janssen Pharmaceuticals, Inc. escetamina para o tratamento da depressão
PL3505157T3 (pl) 2017-12-29 2022-04-11 Celon Pharma S.A. Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie
CN112188889A (zh) * 2018-06-27 2021-01-05 克雷西奥生物科技有限公司 治疗重度抑郁症的方法
EP3860579A1 (en) 2018-10-05 2021-08-11 Clexio Biosciences Ltd. Dosage regime of esketamine for treating major depressive disorder
EP3863617A1 (en) 2018-10-11 2021-08-18 Clexio Biosciences Ltd. Esketamine for use in treating major depressive disorder
CN114126595A (zh) * 2019-03-05 2022-03-01 杨森制药公司 用于治疗抑郁症的艾司氯胺酮
MX2021012383A (es) * 2019-04-09 2022-01-04 Vistagen Therapeutics Inc Variantes genéticas asociadas con la respuesta al tratamiento de trastornos neurológicos.
CA3133012A1 (en) * 2019-08-05 2021-02-11 The Ketamine Research Foundation Ketamine for the treatment of postpartum symptoms and disorders
US20220304950A1 (en) * 2019-08-28 2022-09-29 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of patients with major depressive disorder, including suicidality
KR102312387B1 (ko) * 2019-11-15 2021-10-13 이화여자대학교 산학협력단 인지 증강을 위한 개인 맞춤형 경두개 직류 자극 프로토콜 생성 방법 및 장치
US12478592B2 (en) 2019-12-30 2025-11-25 Clexio Biosciences Ltd. Dosage regime with esketamine for treating neuropsychiatric or neurological conditions
IL293506A (en) 2019-12-30 2022-08-01 Clexio Biosciences Ltd Dosage regime with esketamine for treating major depressive disorder
US20230064327A1 (en) 2020-01-22 2023-03-02 Seelos Therapeutics, Inc. Reducing side effects of nmda antagonists
US20220175701A1 (en) * 2020-12-08 2022-06-09 Therapeutic Solutions International, Inc. Treatment of major depressive disorder and suicidal ideations through stimulation of hippocampal neurogenesis utilizing plant-based approaches
WO2023207729A1 (zh) * 2022-04-26 2023-11-02 宜昌人福药业有限责任公司 艾司氯胺酮液体制剂及其用途
CN115418398B (zh) * 2022-08-30 2025-02-18 广州医科大学附属脑科医院 一组用于预测氯胺酮治疗难治性抑郁症的疗效的标志物及其应用
EP4642445A2 (en) * 2022-12-28 2025-11-05 Perception Neuroscience, Inc. Methods of administering r-ketamine

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH535201A (de) 1969-12-19 1973-03-31 Bristol Myers Co Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren
JPS632932A (ja) 1986-06-23 1988-01-07 Teijin Ltd 経鼻投与用粉末状組成物
USD308100S (en) 1987-08-28 1990-05-22 Schering Corporation Nasal spray pump
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US4994467A (en) 1989-05-31 1991-02-19 Zimmerman Andrew W Treating autism and other developmental disorders in children with NMDA receptor antagonists
DE4312016A1 (de) 1993-04-13 1994-10-20 Goedecke Ag Stabile Ketamin-Lösungen
US5543434A (en) 1994-02-25 1996-08-06 Weg; Stuart L. Nasal administration of ketamine to manage pain
AU733284B2 (en) 1995-02-24 2001-05-10 Stuart L. Weg Nasal and ocular administration of ketamine to manage pain and for detoxification
WO1997007750A1 (en) 1995-08-30 1997-03-06 Weg Stuart L Administration of ketamine to manage pain and to reduce drug dependency
USD401323S (en) 1996-01-23 1998-11-17 Ing. Erich Pfeiffer Gmbh Medication dispensing apparatus
DE19619665C2 (de) 1996-05-15 2001-03-08 Goedecke Ag Racemattrennung von Ketamin
DE19723133A1 (de) 1997-06-03 1998-12-10 Caideil M P Teoranta Tourmakea Austragvorrichtung für Medien
AU135762S (en) 1998-01-09 1998-11-19 Astrazeneca Ab Sprayer
USD433123S (en) 1998-07-09 2000-10-31 Zeneca Limited Nasal spray
PT1113785E (pt) 1998-07-24 2005-08-31 Seo Hong Yoo Solucoes aquosas limpidas de acidos biliares
US6176242B1 (en) 1999-04-30 2001-01-23 Medtronic Inc Method of treating manic depression by brain infusion
US6017961A (en) 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO
EP1103256A1 (de) 1999-11-26 2001-05-30 Claudius Dr. med. Böck Verwendung von Ketamin zur Behandlung von neuroendokriner Immundysfunktion und algogenem Psychosyndrom
US6572849B2 (en) 2000-09-20 2003-06-03 Lee Shahinian, Jr. Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications
US6881731B1 (en) 2000-10-23 2005-04-19 Shanbrom Technologies, Llc Enhancers for microbiological disinfection
USD471973S1 (en) 2001-08-08 2003-03-18 N.V. Organon Applicator for a nasal delivery device
MXPA05000294A (es) 2002-07-30 2005-08-19 Peter Migaly Terapia combinada para la depresion, prevencion de suicidios y varias condiciones medicas y psiquiatricas.
US7273889B2 (en) 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
AU2003291037A1 (en) 2002-11-18 2004-06-15 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs
US7687080B2 (en) 2002-11-25 2010-03-30 Taraxos Inc. Treatment of neuropathy
US20040214215A1 (en) 2003-03-07 2004-10-28 Yu Ruey J. Bioavailability and improved delivery of alkaline pharmaceutical drugs
US8082173B2 (en) 2003-05-22 2011-12-20 Cecil Kost Drug sample fulfillment architecture
US20040265364A1 (en) 2003-06-25 2004-12-30 Binnur Ozturk Neuropathy cream
US20050095277A1 (en) 2003-06-25 2005-05-05 Binnur Ozturk Neuropathy cream
USD544957S1 (en) 2005-03-23 2007-06-19 Rexam Dispensing Systems Nasal spray dispenser
US20060223788A1 (en) 2005-03-29 2006-10-05 Cathcart Clifton H Analgesic composition for topical use
CA111438S (fr) 2005-05-23 2006-12-22 Rexam Dispensing Sys Pulvérisateur nasal
EP2526987A3 (en) 2005-06-01 2013-04-24 SHL Group AB Device for delivering medicament
US20060276550A1 (en) 2005-06-03 2006-12-07 Dileep Bhagwat Topical compositions of ketamine and butamben and methods of their use
CN101466364A (zh) 2006-03-22 2009-06-24 纽约大学西奈山医学院 鼻内施用氯胺酮治疗抑郁症
US20070256688A1 (en) 2006-04-21 2007-11-08 Aradigm Corporation Mechanical single dose intrapulmonary drug delivery devices
EP2029136A4 (en) 2006-05-22 2010-01-06 Vanda Pharmaceuticals Inc TREATMENT FOR DEPRESSION DISEASES
DE102007009888A1 (de) 2007-02-28 2008-09-04 Hermann, Holger Lars, Dr. Verwendung von S-(+)-Ketamin zur Behandlung von Depressionen
US20100095957A1 (en) 2007-03-02 2010-04-22 Corbco, Inc. Manually operated monodose nasal sprayer device
WO2008151179A2 (en) 2007-06-04 2008-12-11 Auspex Pharmaceuticals, Inc. Substituted phenethylamines
WO2009131794A1 (en) 2008-03-27 2009-10-29 University Of Kentucky Research Foundation Opioid-ketamine and norketamine codrug combinations for pain management
USD610253S1 (en) 2009-03-31 2010-02-16 Daikyo Seiko, Ltd. Pre-filled nasal drip device
USD610678S1 (en) 2009-03-31 2010-02-23 Daikyo Seiko, Ltd. Syringe plunger and proximal end of a syringe barrel for a pre-filled nasal drip device
US20120225949A1 (en) 2009-08-14 2012-09-06 Demitri Papalos Compositions and methods for treating bipolar disorder
US20110038807A1 (en) 2009-08-14 2011-02-17 Demitri Papolos Compositions and methods for treating bipolar disorder
US8846765B2 (en) 2010-06-15 2014-09-30 Gruenenthal Gmbh Pharmaceutical combination
USD699342S1 (en) 2011-03-09 2014-02-11 Suzuken Company Limited Injector
US9073819B2 (en) 2011-06-30 2015-07-07 University Of South Florida Compositions, methods of use, and methods of treatment
USD697201S1 (en) 2011-07-01 2014-01-07 R5 Pharmaceuticals Limited Buccal delivery device adaptor
US20130056557A1 (en) 2011-09-02 2013-03-07 Maggie Blair Felder Non-pressurized flavored liquid oxygen breath spray device
EP3904332B1 (en) 2011-10-14 2024-12-04 The United States of America, as represented by The Secretary, Department of Health and Human Services The use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain
EP2780467B1 (en) 2011-11-14 2018-10-17 Alfasigma S.p.A. Assays and methods for selecting a treatment regimen for a subject with depression and methods for treatment
US20130209585A1 (en) 2012-02-13 2013-08-15 Stanley Kim Topical NMDA Antagonist Formulations for the Treatment of Peripheral Neuropathy
CN104519878A (zh) * 2012-03-12 2015-04-15 詹森药业有限公司 用于治疗顽固性或难治性抑郁症的艾氯胺酮
AU2016203771A1 (en) 2012-03-13 2016-06-23 Janssen Pharmaceutica Nv Esketamine for the treatment of treatment-refractory or treatment-resistant depression
JP2015512418A (ja) 2012-03-30 2015-04-27 ザ ジェネラル ホスピタル コーポレイション うつ病の治療におけるスコポラミンおよびケタミンを含む組成物
US20140079740A1 (en) 2012-08-02 2014-03-20 ClinPharm Support GmbH Oral transmucosal adminstration forms of s-ketamine
KR20150096370A (ko) 2012-08-23 2015-08-24 스튜어트 엘. 웨그 항불안제 조성물, 제형 및 사용방법
FR2994844B1 (fr) 2012-08-31 2015-01-02 Assist Publ Hopitaux De Paris Formulation gelifiante a base de ketamine
NZ619257A (en) 2012-10-08 2015-07-31 Auckland Uniservices Ltd Ketamine derivatives
ES2484068B1 (es) 2013-02-08 2015-04-16 Ana MÍNGUEZ MARTÍ Una composición farmacéutica que contiene ketamina y amitriptilina
US20140263456A1 (en) 2013-03-15 2014-09-18 Launce R. Barber Child-resistant closure systems for containers
US20140263457A1 (en) 2013-03-15 2014-09-18 Launce R. Barber Child-resistant closure systems for containers
KR20150142012A (ko) 2013-04-12 2015-12-21 이칸 스쿨 오브 메디슨 엣 마운트 시나이 외상후 스트레스 장애의 치료 방법
US9913803B2 (en) 2013-08-26 2018-03-13 Amorsa Therapeutics, Inc. Single-layer oral dose of neuro-attenuating ketamine
RS62516B1 (sr) 2013-09-13 2021-11-30 Univ Chiba Nat Univ Corp Primena r-ketamina i njegove soli kao farmaceutskih proizvoda
US9569220B2 (en) 2013-10-06 2017-02-14 Synopsys, Inc. Processor branch cache with secondary branches
CN103705909A (zh) 2013-12-16 2014-04-09 陈镜伊 一种无痛人流用药
WO2015101693A1 (es) 2013-12-31 2015-07-09 Servicio Andaluz De Salud Composiciones y preparaciones combinadas para el tratamiento de las algias orofaríngeas
WO2015108985A1 (en) 2014-01-14 2015-07-23 Children's Hospital Medical Center Compositions comprising ketamine for treating an autism spectrum disorder
ES2829279T3 (es) 2014-04-17 2021-05-31 Develco Pharma Schweiz Ag Forma de dosificación oral de ketamina
FR3023188B1 (fr) 2014-07-04 2016-08-19 Aptar France Sas Dispositif de distribution de produit fluide.
JP6545788B2 (ja) 2014-08-13 2019-07-17 ヤンセン ファーマシューティカ エヌ.ベー. うつ病の治療方法
WO2016044150A1 (en) 2014-09-15 2016-03-24 Janssen Pharmaceutica Nv VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION
WO2016109427A1 (en) 2014-12-31 2016-07-07 Icahn School Of Medicine At Mount Sinai Method of maintaining the anti-depressant effect of ketamine with lithium
CN104798728A (zh) 2015-05-08 2015-07-29 南京中医药大学 产后抑郁动物模型的建立方法及其应用
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
US20160338977A1 (en) 2015-05-20 2016-11-24 Janssen Pharmaceutica Nv Methods and kits for treating depression
JP6845162B2 (ja) 2015-06-27 2021-03-17 シェノックス・ファーマシューティカルズ・エルエルシー ケタミン経皮送達システム
US20180296478A1 (en) 2016-02-12 2018-10-18 Synergistic Therapeutics, Llc Sublingual antidepressant and antianxiety tablet
US20180042936A1 (en) 2016-03-18 2018-02-15 Genomind, Inc. Maintenance therapy using tianeptine
BR112020012473A2 (pt) 2017-12-22 2020-11-24 Janssen Pharmaceuticals, Inc. escetamina para o tratamento da depressão

Also Published As

Publication number Publication date
KR20170054470A (ko) 2017-05-17
US20200246279A1 (en) 2020-08-06
US11173134B2 (en) 2021-11-16
CA2961208A1 (en) 2016-03-24
US20210308076A1 (en) 2021-10-07
IL279119A (en) 2021-01-31
US20230089113A1 (en) 2023-03-23
US10869844B2 (en) 2020-12-22
US20210106545A1 (en) 2021-04-15
MA40620A (fr) 2016-03-24
JP2017528483A (ja) 2017-09-28
EP3193853A1 (en) 2017-07-26
US20250255835A1 (en) 2025-08-14
AU2015318123A1 (en) 2017-03-30
US11311500B2 (en) 2022-04-26
EP3725307A1 (en) 2020-10-21
US20160074340A1 (en) 2016-03-17
JP2021054829A (ja) 2021-04-08
WO2016044150A1 (en) 2016-03-24
MX2017003366A (es) 2018-02-01
CN107208133A (zh) 2017-09-26

Similar Documents

Publication Publication Date Title
IL279119A (en) VAL66MET genotype-specific dosage regimens (SNP rs6265) and methods for treating depression
IL289475A (en) Molecules that activate t cells are selectively regulated for the treatment of autoimmune diseases
IL279627A (en) A method for treating depression
IL250672A0 (en) Treatment regimens using anti-nkg2a antibodies
GB201717662D0 (en) Software development and distribution platform
IL249370A0 (en) Fap-enabled medical substances and related uses
GB201711202D0 (en) Advanced processor architecture
PL2957479T3 (pl) Stelaż wózka dziecięcego i wózek dziecięcy
EP3103055A4 (en) Multi-level assurance trusted computing platform
SI3347054T1 (sl) Režimi doziranja konjugatov zdravil proti TF protitelesu
GB201407322D0 (en) Gene therapy
GB201513419D0 (en) Paintbrush and liquid simulation
ZA201704321B (en) Electronic calculating device for performing obfuscated arithmetic
IL247325A0 (en) Therapeutic methods using noribogaine and related compounds
IL251870A0 (en) Dosing regimens of buprenorphine
GB201521217D0 (en) Dosage regimens
IL266292A (en) treatment regimens
GB201417661D0 (en) Agile Software Development Process And Results
DK3115051T3 (da) Endoparasit kontrol agens
GB201418393D0 (en) Computer implemented game
GB201713894D0 (en) Genotype determination device and method
IL248506A0 (en) Dosage regimens of nitisinone for the treatment of alkeptonuria
TH1601002905A (th) วิธีการและองค์ประกอบสำหรับการดัดแปลงที่มีเป้าหมายของจีโนม