IL251052B - Detection of unfolded proteins - Google Patents
Detection of unfolded proteinsInfo
- Publication number
- IL251052B IL251052B IL251052A IL25105217A IL251052B IL 251052 B IL251052 B IL 251052B IL 251052 A IL251052 A IL 251052A IL 25105217 A IL25105217 A IL 25105217A IL 251052 B IL251052 B IL 251052B
- Authority
- IL
- Israel
- Prior art keywords
- detection
- misfolded proteins
- misfolded
- proteins
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049306P | 2014-09-11 | 2014-09-11 | |
| PCT/US2015/049844 WO2016040907A1 (en) | 2014-09-11 | 2015-09-11 | Detection of misfolded proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL251052A0 IL251052A0 (en) | 2017-04-30 |
| IL251052B true IL251052B (en) | 2022-05-01 |
Family
ID=55454515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL251052A IL251052B (en) | 2014-09-11 | 2017-03-09 | Detection of unfolded proteins |
| IL291809A IL291809B2 (en) | 2014-09-11 | 2022-03-30 | Detection of unfolded proteins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL291809A IL291809B2 (en) | 2014-09-11 | 2022-03-30 | Detection of unfolded proteins |
Country Status (15)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040905A1 (en) | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded alpha synuclein protein |
| GB201611840D0 (en) * | 2016-07-07 | 2016-08-24 | Univ Court Of The Univ Of Edinburgh The | Alpha-synuclein detection assay |
| SG11201906947SA (en) | 2017-02-17 | 2019-08-27 | Bristol Myers Squibb Co | Antibodies to alpha-synuclein and uses thereof |
| EP3635393A4 (en) * | 2017-05-16 | 2021-03-10 | Claudio Soto-Jara | DETECTION OF MISFOLDED TAU PROTEIN |
| EP3692373A1 (en) * | 2017-10-02 | 2020-08-12 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| US20200309796A1 (en) * | 2017-12-21 | 2020-10-01 | H. Lundbeck A/S | Assay, method and treatment of alpha-synucleinopathies |
| CN108088816A (zh) * | 2018-01-23 | 2018-05-29 | 深圳市国赛生物技术有限公司 | 小型特定蛋白分析仪 |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| WO2019222554A2 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of brain injury or neurological disease using tau protein |
| CN112585685A (zh) * | 2018-09-21 | 2021-03-30 | 渊慧科技有限公司 | 确定蛋白结构的机器学习 |
| JP7376040B2 (ja) * | 2019-09-03 | 2023-11-08 | 国立大学法人京都工芸繊維大学 | 神経変性疾患におけるバイオマーカー分子の検出方法 |
| WO2021046174A1 (en) * | 2019-09-04 | 2021-03-11 | Amprion, Inc. | Alpha-synuclein detection using beads |
| KR102277871B1 (ko) * | 2019-12-17 | 2021-07-15 | 원광대학교산학협력단 | 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트 |
| WO2021198098A1 (en) | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
| CA3199642A1 (en) * | 2020-11-21 | 2022-05-27 | Shuwen Biotech Co. Ltd. | Apparatus and method for detecting misfolded protein in biological sample |
| WO2022221876A1 (en) * | 2021-04-15 | 2022-10-20 | The Brigham And Women's Hospital, Inc. | Digital protein misfolding assays |
| CN114199875B (zh) * | 2022-02-18 | 2022-05-20 | 之江实验室 | 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE335204T1 (de) | 2000-07-07 | 2006-08-15 | Applied Research Systems | Frühdiagnose von konformationellen erkrankungen |
| WO2002054083A2 (en) | 2001-01-03 | 2002-07-11 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| EP1820806A1 (en) * | 2006-02-16 | 2007-08-22 | Crossbeta Biosciences B.V. | Affinity regions |
| AU2006214463B2 (en) * | 2005-02-15 | 2012-08-30 | Presympto, Inc. | Method for detecting misfolded proteins and prions |
| ATE528008T1 (de) * | 2006-05-19 | 2011-10-15 | Alnylam Pharmaceuticals Inc | Rnai-modulation von aha und ihre therapeutische verwendung |
| EP2074222A4 (en) * | 2006-09-06 | 2010-03-03 | Univ Texas | METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS |
| JP2010043865A (ja) * | 2006-12-12 | 2010-02-25 | Olympus Corp | 異常型プリオンの検出方法 |
| JP2013511734A (ja) * | 2009-11-24 | 2013-04-04 | プロビオドルグ エージー | アルツハイマー病又は軽度認知障害の診断のための新規診断方法 |
| US9133343B2 (en) * | 2009-11-30 | 2015-09-15 | Enzo Biochem, Inc. | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications |
| EP2666020A1 (en) * | 2011-01-18 | 2013-11-27 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for amplification and detection of prions |
| US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| WO2016040903A1 (en) * | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded amyloid beta protein |
-
2015
- 2015-09-11 EP EP23189057.5A patent/EP4292654A3/en active Pending
- 2015-09-11 CN CN201580058606.3A patent/CN107208125A/zh active Pending
- 2015-09-11 PL PL15839278.7T patent/PL3191599T3/pl unknown
- 2015-09-11 JP JP2017533721A patent/JP6980953B2/ja active Active
- 2015-09-11 HR HRP20231232TT patent/HRP20231232T1/hr unknown
- 2015-09-11 US US14/852,478 patent/US20160077112A1/en not_active Abandoned
- 2015-09-11 KR KR1020177009707A patent/KR102448128B1/ko active IP Right Grant
- 2015-09-11 BR BR112017004899A patent/BR112017004899A2/pt active Search and Examination
- 2015-09-11 SG SG11201701953RA patent/SG11201701953RA/en unknown
- 2015-09-11 CA CA2960830A patent/CA2960830C/en active Active
- 2015-09-11 EP EP15839278.7A patent/EP3191599B1/en active Active
- 2015-09-11 MX MX2017003269A patent/MX2017003269A/es unknown
- 2015-09-11 WO PCT/US2015/049844 patent/WO2016040907A1/en active Application Filing
- 2015-09-11 SG SG10202008464UA patent/SG10202008464UA/en unknown
- 2015-09-11 AU AU2015314783A patent/AU2015314783B2/en active Active
- 2015-09-11 ES ES15839278T patent/ES2953855T3/es active Active
-
2017
- 2017-03-09 IL IL251052A patent/IL251052B/en unknown
-
2021
- 2021-05-12 JP JP2021081274A patent/JP7104943B2/ja active Active
-
2022
- 2022-03-30 IL IL291809A patent/IL291809B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3191599C0 (en) | 2023-08-02 |
| US20160077112A1 (en) | 2016-03-17 |
| EP4292654A2 (en) | 2023-12-20 |
| JP7104943B2 (ja) | 2022-07-22 |
| ES2953855T3 (es) | 2023-11-16 |
| SG11201701953RA (en) | 2017-04-27 |
| KR20170103741A (ko) | 2017-09-13 |
| AU2015314783A1 (en) | 2017-04-27 |
| JP6980953B2 (ja) | 2021-12-15 |
| WO2016040907A1 (en) | 2016-03-17 |
| JP2017530373A (ja) | 2017-10-12 |
| CA2960830C (en) | 2023-09-05 |
| CA2960830A1 (en) | 2016-03-17 |
| IL251052A0 (en) | 2017-04-30 |
| PL3191599T3 (pl) | 2023-12-27 |
| JP2022000629A (ja) | 2022-01-04 |
| MX2017003269A (es) | 2017-12-04 |
| HRP20231232T1 (hr) | 2024-01-19 |
| CN107208125A (zh) | 2017-09-26 |
| BR112017004899A2 (pt) | 2017-12-12 |
| EP3191599A1 (en) | 2017-07-19 |
| IL291809B2 (en) | 2023-06-01 |
| EP4292654A3 (en) | 2024-01-03 |
| SG10202008464UA (en) | 2020-10-29 |
| IL291809A (en) | 2022-06-01 |
| AU2015314783B2 (en) | 2021-10-21 |
| KR102448128B1 (ko) | 2022-09-27 |
| EP3191599A4 (en) | 2018-03-14 |
| EP3191599B1 (en) | 2023-08-02 |
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