IL245404A0 - Thianopyrimidines as mknk1 and mknk2 inhibitors - Google Patents

Thianopyrimidines as mknk1 and mknk2 inhibitors

Info

Publication number
IL245404A0
IL245404A0 IL245404A IL24540416A IL245404A0 IL 245404 A0 IL245404 A0 IL 245404A0 IL 245404 A IL245404 A IL 245404A IL 24540416 A IL24540416 A IL 24540416A IL 245404 A0 IL245404 A0 IL 245404A0
Authority
IL
Israel
Prior art keywords
thienopyrimidines
mknk1
mknk2
inhibitors
mknk2 inhibitors
Prior art date
Application number
IL245404A
Other languages
English (en)
Hebrew (he)
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of IL245404A0 publication Critical patent/IL245404A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL245404A 2013-11-20 2016-05-02 Thianopyrimidines as mknk1 and mknk2 inhibitors IL245404A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13193665 2013-11-20
EP14174731 2014-06-27
PCT/EP2014/074722 WO2015074986A1 (en) 2013-11-20 2014-11-17 Thienopyrimidines as mknk1 and mknk2 inhibitors

Publications (1)

Publication Number Publication Date
IL245404A0 true IL245404A0 (en) 2016-06-30

Family

ID=52000798

Family Applications (1)

Application Number Title Priority Date Filing Date
IL245404A IL245404A0 (en) 2013-11-20 2016-05-02 Thianopyrimidines as mknk1 and mknk2 inhibitors

Country Status (22)

Country Link
US (1) US20160297833A1 (ko)
EP (1) EP3071577A1 (ko)
JP (1) JP2016539113A (ko)
KR (1) KR20160086404A (ko)
CN (1) CN106061980A (ko)
AP (1) AP2016009225A0 (ko)
AU (1) AU2014352066A1 (ko)
BR (1) BR112016011472A2 (ko)
CA (1) CA2930873A1 (ko)
CL (1) CL2016001218A1 (ko)
CR (1) CR20160235A (ko)
CU (1) CU20160072A7 (ko)
DO (1) DOP2016000118A (ko)
EA (1) EA201600398A1 (ko)
IL (1) IL245404A0 (ko)
MX (1) MX2016006631A (ko)
PE (1) PE20160593A1 (ko)
PH (1) PH12016500931A1 (ko)
TN (1) TN2016000194A1 (ko)
TW (1) TW201605867A (ko)
UY (1) UY35848A (ko)
WO (1) WO2015074986A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
JP6892444B2 (ja) 2015-10-29 2021-06-23 イーフェクター セラピューティクス， インコーポレイテッド Ｍｎｋ１およびｍｎｋ２のイソインドリン、アザイソインドリン、ジヒドロインデノンならびにジヒドロアザインデノン阻害薬
KR20180070696A (ko) * 2015-10-29 2018-06-26 이펙터 테라퓨틱스, 인크. Mnk1 및 mnk2를 억제하는 피롤로-, 피라졸로-, 이미다조-피리미딘 및 피리딘 화합물
US10000487B2 (en) 2015-11-20 2018-06-19 Effector Therapeutics, Inc. Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物
US20190388425A1 (en) 2017-01-20 2019-12-26 Bayer Pharma Aktiengesellschaft Substituted imidazopyridinpyrimidines
EA201991894A1 (ru) 2017-02-14 2020-02-05 Эффектор Терапьютикс, Инк. ПИПЕРИДИН-ЗАМЕЩЕННЫЕ ИНГИБИТОРЫ Mnk И СВЯЗАННЫЕ С НИМИ СПОСОБЫ
BR112021007745A2 (pt) 2018-10-24 2021-07-27 Effector Therapeutics, Inc. formas cristalinas de inibidores de mnk
CN110981903A (zh) * 2019-11-28 2020-04-10 南京正济医药研究有限公司 一种艾日布林中间体化合物提高光学纯度的精制方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101100472A (zh) * 2001-04-30 2008-01-09 美国拜尔公司 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
US20040014755A1 (en) * 2002-01-10 2004-01-22 Dhanapalan Nagarathnam Rho-kinase inhibitors
DE602004003952T2 (de) * 2003-07-24 2007-11-08 Bayer Pharmaceuticals Corp., West Haven Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders
EP1799653B1 (en) * 2004-08-20 2013-03-20 Bayer Intellectual Property GmbH Condensed thienopyrimidine derivatives for the treatment of cancer
UY29161A1 (es) * 2004-10-15 2006-04-28 Bayer Pharmaceuticals Corp Nuevos heterociclos
EP1899353A1 (en) * 2005-06-22 2008-03-19 DeveloGen Aktiengesellschaft Thienopyrimidines for pharmaceutical compositions
WO2007059905A2 (en) * 2005-11-25 2007-05-31 Develogen Aktiengesellschaft Thienopyrimidines treating inflammatory diseases
BR112012021364A2 (pt) * 2010-02-26 2016-10-25 Boehringer Ingelheim Int "compostos cicloalquila contendo tienopirimidinas e composições farmacêuticas".
WO2013106535A1 (en) * 2012-01-10 2013-07-18 Nimbus Iris, Inc. Irak inhibitors and uses thereof
ES2592404T3 (es) * 2012-05-21 2016-11-30 Bayer Pharma Aktiengesellschaft Benzotienopirimidinas sustituidas
EP2852593A1 (en) * 2012-05-21 2015-04-01 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyrimidines
CA2873975A1 (en) * 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Thienopyrimidines
EP2951187A1 (en) * 2013-02-01 2015-12-09 Bayer Pharma Aktiengesellschaft Substituted thienopyrimidines and pharmaceutical use thereof
EP3019505A1 (en) * 2013-07-08 2016-05-18 Bayer Pharma Aktiengesellschaft Substituted pyrazolo-pyridinamines

Also Published As

Publication number Publication date
DOP2016000118A (es) 2016-06-30
PH12016500931A1 (en) 2016-06-27
WO2015074986A1 (en) 2015-05-28
AU2014352066A1 (en) 2016-05-26
TN2016000194A1 (en) 2017-10-06
CR20160235A (es) 2016-07-20
UY35848A (es) 2015-06-30
AP2016009225A0 (en) 2016-05-31
CL2016001218A1 (es) 2016-12-16
CN106061980A (zh) 2016-10-26
MX2016006631A (es) 2016-08-17
TW201605867A (zh) 2016-02-16
CU20160072A7 (es) 2016-10-28
CA2930873A1 (en) 2015-05-28
US20160297833A1 (en) 2016-10-13
EP3071577A1 (en) 2016-09-28
PE20160593A1 (es) 2016-07-13
KR20160086404A (ko) 2016-07-19
EA201600398A1 (ru) 2016-10-31
JP2016539113A (ja) 2016-12-15
BR112016011472A2 (pt) 2017-09-26

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