IL241964B - Combined treatment including a tor kinase inhibitor and an imide compound for cancer treatment - Google Patents

Combined treatment including a tor kinase inhibitor and an imide compound for cancer treatment

Info

Publication number
IL241964B
IL241964B IL241964A IL24196415A IL241964B IL 241964 B IL241964 B IL 241964B IL 241964 A IL241964 A IL 241964A IL 24196415 A IL24196415 A IL 24196415A IL 241964 B IL241964 B IL 241964B
Authority
IL
Israel
Prior art keywords
combination therapy
kinase inhibitor
treating cancer
tor kinase
imid compound
Prior art date
Application number
IL241964A
Other languages
English (en)
Hebrew (he)
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of IL241964B publication Critical patent/IL241964B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL241964A 2013-04-17 2015-10-08 Combined treatment including a tor kinase inhibitor and an imide compound for cancer treatment IL241964B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361813094P 2013-04-17 2013-04-17
US201361908859P 2013-11-26 2013-11-26
PCT/US2014/034312 WO2014172429A1 (en) 2013-04-17 2014-04-16 Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer

Publications (1)

Publication Number Publication Date
IL241964B true IL241964B (en) 2020-01-30

Family

ID=50736198

Family Applications (1)

Application Number Title Priority Date Filing Date
IL241964A IL241964B (en) 2013-04-17 2015-10-08 Combined treatment including a tor kinase inhibitor and an imide compound for cancer treatment

Country Status (15)

Country Link
US (2) US20140314752A1 (enExample)
EP (1) EP2986318A1 (enExample)
JP (1) JP6389241B2 (enExample)
KR (2) KR102223060B1 (enExample)
CN (1) CN105358177B (enExample)
AU (1) AU2014254056B2 (enExample)
BR (1) BR112015026006B1 (enExample)
CA (1) CA2908954C (enExample)
HK (1) HK1221148A1 (enExample)
IL (1) IL241964B (enExample)
MX (2) MX373803B (enExample)
NZ (1) NZ629456A (enExample)
TW (1) TW201526897A (enExample)
WO (1) WO2014172429A1 (enExample)
ZA (1) ZA201507735B (enExample)

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CN107474051B (zh) 2013-05-29 2020-10-30 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
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CN106769807A (zh) * 2016-12-07 2017-05-31 王兰英 一种利用流式细胞仪检测HeLa细胞凋亡的方法
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TW201922256A (zh) 2017-10-27 2019-06-16 中國大陸商浙江導明醫藥科技有限公司 治療淋巴樣惡性疾病之方法
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CN114502176A (zh) * 2019-10-04 2022-05-13 达纳-法伯癌症研究所股份有限公司 作为zeta链相关蛋白激酶70(zap70)激动剂的免疫调节性酰亚胺药物及其用途
CN115916191B (zh) * 2020-06-25 2026-06-23 新基公司 用组合疗法治疗癌症的方法
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Also Published As

Publication number Publication date
CA2908954A1 (en) 2014-10-23
CA2908954C (en) 2021-08-03
NZ629456A (en) 2017-06-30
ZA201507735B (en) 2017-06-28
TW201526897A (zh) 2015-07-16
KR102223060B1 (ko) 2021-03-05
US20200113896A1 (en) 2020-04-16
HK1221148A1 (zh) 2017-05-26
BR112015026006A2 (pt) 2017-07-25
WO2014172429A1 (en) 2014-10-23
CN105358177A (zh) 2016-02-24
MX2015014596A (es) 2016-03-03
EP2986318A1 (en) 2016-02-24
AU2014254056B2 (en) 2019-06-06
KR20160002791A (ko) 2016-01-08
US20140314752A1 (en) 2014-10-23
KR102382576B1 (ko) 2022-04-08
AU2014254056A1 (en) 2015-11-05
JP6389241B2 (ja) 2018-09-12
JP2016516817A (ja) 2016-06-09
BR112015026006A8 (pt) 2020-01-14
MX2020003174A (es) 2020-07-28
KR20210024231A (ko) 2021-03-04
MX373803B (es) 2020-03-24
CN105358177B (zh) 2018-11-23
BR112015026006B1 (pt) 2022-10-18

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